1HTO

CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1htoa1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
A	d1htoa2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d1htob1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
B	d1htob2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
C	d1htoc1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
C	d1htoc2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
D	d1htod1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
D	d1htod2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
E	d1htoe1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
E	d1htoe2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
F	d1htof1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
F	d1htof2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
G	d1htog1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
G	d1htog2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
H	d1htoh1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
H	d1htoh2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
I	d1htoi1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
I	d1htoi2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
J	d1htoj1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
J	d1htoj2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
K	d1htok1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
K	d1htok2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
L	d1htol1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
L	d1htol2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
M	d1htom1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
M	d1htom2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
N	d1hton1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
N	d1hton2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
O	d1htoo1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
O	d1htoo2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
P	d1htop1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
P	d1htop2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
Q	d1htoq1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
Q	d1htoq2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
R	d1htor1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
R	d1htor2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
S	d1htos1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
S	d1htos2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
T	d1htot1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
T	d1htot2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
U	d1htou1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
U	d1htou2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
V	d1htov1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
V	d1htov2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
W	d1htow1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
W	d1htow2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
X	d1htox1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	Glutamine synthetase, N-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)
X	d1htox2	Alpha and beta proteins (a+b)	Glutamine synthetase/guanido kinase	Glutamine synthetase/guanido kinase	Glutamine synthetase catalytic domain	Glutamine synthetase, C-terminal domain	(Mycobacterium tuberculosis ) [TaxId: 1773 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	GS N-terminal domain-like	8038669	3000408	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Glutamine synthetase/guanido kinase	8038671	3000676	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Gln-synt_N	e1htoA2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
A	Gln-synt_C	e1htoA1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
B	Gln-synt_N	e1htoB2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
B	Gln-synt_C	e1htoB1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
C	Gln-synt_N	e1htoC2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
C	Gln-synt_C	e1htoC1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
D	Gln-synt_N	e1htoD2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
D	Gln-synt_C	e1htoD1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
E	Gln-synt_N	e1htoE2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
E	Gln-synt_C	e1htoE1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
F	Gln-synt_N	e1htoF2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
F	Gln-synt_C	e1htoF1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
G	Gln-synt_N	e1htoG2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
G	Gln-synt_C	e1htoG1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
H	Gln-synt_N	e1htoH2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
H	Gln-synt_C	e1htoH1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
I	Gln-synt_N	e1htoI2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
I	Gln-synt_C	e1htoI1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
J	Gln-synt_N	e1htoJ2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
J	Gln-synt_C	e1htoJ1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
K	Gln-synt_N	e1htoK2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
K	Gln-synt_C	e1htoK1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
L	Gln-synt_N	e1htoL2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
L	Gln-synt_C	e1htoL1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
M	Gln-synt_N	e1htoM2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
M	Gln-synt_C	e1htoM1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
N	Gln-synt_N	e1htoN2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
N	Gln-synt_C	e1htoN1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
O	Gln-synt_N	e1htoO2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
O	Gln-synt_C	e1htoO1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
P	Gln-synt_N	e1htoP2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
P	Gln-synt_C	e1htoP1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
Q	Gln-synt_N	e1htoQ2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
Q	Gln-synt_C	e1htoQ1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
R	Gln-synt_N	e1htoR2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
R	Gln-synt_C	e1htoR1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
S	Gln-synt_N	e1htoS2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
S	Gln-synt_C	e1htoS1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
T	Gln-synt_N	e1htoT2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
T	Gln-synt_C	e1htoT1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
U	Gln-synt_N	e1htoU2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
U	Gln-synt_C	e1htoU1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
V	Gln-synt_N	e1htoV2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
V	Gln-synt_C	e1htoV1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
W	Gln-synt_N	e1htoW2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
W	Gln-synt_C	e1htoW1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)
X	Gln-synt_N	e1htoX2	A: beta barrels	X: Ribosomal protein L25-like	H: Glutamine synthetase, N-terminal domain (From Topology)	T: Glutamine synthetase, N-terminal domain	F: Gln-synt_N	ECOD (1.6)
X	Gln-synt_C	e1htoX1	A: a+b two layers	X: Glutamine synthetase-like	H: Glutamine synthetase/guanido kinase (From Topology)	T: Glutamine synthetase/guanido kinase	F: Gln-synt_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
A	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
B	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
B	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
C	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
C	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
D	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
D	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
E	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
E	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
F	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
F	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
G	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
G	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
H	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
H	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
I	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
I	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
J	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
J	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
K	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
K	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
L	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
L	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
M	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
M	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
N	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
N	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
O	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
O	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
P	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
P	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
Q	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
Q	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
R	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
R	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
S	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
S	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
T	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
T	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
U	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
U	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
V	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
V	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
W	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
W	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)
X	3.30.590.10	Alpha Beta	2-Layer Sandwich	Creatine Kinase	Chain A, domain 2	CATH (4.3.0)
X	3.10.20.70	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Glutamine synthetase, N-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF00120	Glutamine synthetase, catalytic domain (Gln-synt_C)	Glutamine synthetase, catalytic domain	-	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF03951	Glutamine synthetase, beta-Grasp domain (Gln-synt_N)	Glutamine synthetase, beta-Grasp domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	GLUTAMINE SYNTHETASE	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding protein binding enzyme binding zymogen binding fibronectin binding acid-ammonia (or amide) ligase activity ammonia ligase activity glutamine synthetase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	response to nutrient levels cellular homeostasis chemical homeostasis response to stimulus homeostatic process intracellular nitrogen homeostasis nitrogen utilization intracellular chemical homeostasis regulation of protein maturation positive regulation of protein maturation regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation response to nutrient levels cellular homeostasis chemical homeostasis response to stimulus homeostatic process intracellular nitrogen homeostasis nitrogen utilization intracellular chemical homeostasis regulation of protein maturation positive regulation of protein maturation regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation zymogen activation regulation of biological process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of proteolysis regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of plasminogen activation protein metabolic process positive regulation of cellular process regulation of biosynthetic process organonitrogen compound metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression cellular process positive regulation of cellular biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis glutamine family amino acid biosynthetic process oxoacid metabolic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process small molecule metabolic process glutamine metabolic process small molecule biosynthetic process carboxylic acid metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process glutamine biosynthetic process alpha-amino acid biosynthetic process	membrane cellular anatomical entity extracellular region intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR004809	Glutamine synthetase type I	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR008146	Glutamine synthetase, catalytic domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR001637	Glutamine synthetase class-I, adenylation site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR027303	Glutamine synthetase, glycine-rich site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR027302	Glutamine synthetase, N-terminal conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR014746	Glutamine synthetase/guanido kinase, catalytic domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR008147	Glutamine synthetase, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR036651	Glutamine synthetase, N-terminal domain superfamily	Homologous Superfamily