1HOD

NMR STRUCTURE OF D130I MUTANT T3-I2, A 32 RESIDUE PEPTIDE FROM THE ALPHA 2A ADRENERGIC RECEPTOR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hoda_	Peptides	alpha-2a adrenergic receptor pepride t3-i2	alpha-2a adrenergic receptor pepride t3-i2	alpha-2a adrenergic receptor pepride t3-i2	alpha-2a adrenergic receptor pepride t3-i2	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ALPHA-2A ADRENERGIC RECEPTOR	thioesterase binding protein binding binding enzyme binding adrenergic receptor binding signaling receptor binding alpha-1B adrenergic receptor binding G protein-coupled receptor binding alpha-adrenergic receptor activity G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity thioesterase binding protein binding binding enzyme binding adrenergic receptor binding signaling receptor binding alpha-1B adrenergic receptor binding G protein-coupled receptor binding alpha-adrenergic receptor activity G protein-coupled amine receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity adrenergic receptor activity alpha2-adrenergic receptor activity protein heterodimerization activity protein dimerization activity protein-containing complex binding heterotrimeric G-protein binding identical protein binding protein homodimerization activity kinase binding protein kinase binding alpha-2C adrenergic receptor binding cation binding ion binding catecholamine binding organic cyclic compound binding norepinephrine binding small molecule binding epinephrine binding hormone binding	trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling trans-synaptic signaling regulation of biological process regulation of signaling regulation of cellular process modulation of chemical synaptic transmission signaling biological regulation cell-cell signaling presynaptic modulation of chemical synaptic transmission chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular process cellular response to stimulus response to stimulus receptor transactivation positive regulation of signaling receptor activity regulation of signaling receptor activity regulation of signal transduction positive regulation of molecular function regulation of molecular function regulation of response to stimulus signal transduction positive regulation of response to wounding wound healing positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing response to stress regulation of response to stress regulation of wound healing response to wounding positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of protein modification process organic substance metabolic process protein metabolic process activation of protein kinase B activity positive regulation of protein kinase activity positive regulation of cellular process organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of phosphorylation phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-activating adrenergic receptor signaling pathway adrenergic receptor signaling pathway G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway multicellular organismal process system process thermoception sensory perception nervous system process sensory perception of temperature stimulus digestion intestinal absorption digestive system process regulation of tube diameter regulation of tube size regulation of system process circulatory system process regulation of blood circulation regulation of vasoconstriction vascular process in circulatory system regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality blood circulation vasoconstriction regulation of anatomical structure size cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization positive regulation of cell communication positive regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway cell surface receptor signaling pathway ERBB signaling pathway positive regulation of signaling fear response multicellular organismal response to stress regulation of localization regulation of calcium ion transport transport regulation of transport negative regulation of monoatomic ion transport regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport establishment of localization calcium ion transport metal ion transport negative regulation of calcium ion transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulated exocytosis regulation of calcium ion-dependent exocytosis negative regulation of regulated secretory pathway vesicle-mediated transport regulation of regulated secretory pathway secretion by cell regulation of secretion by cell negative regulation of secretion negative regulation of exocytosis negative regulation of cellular process negative regulation of secretion by cell calcium-ion regulated exocytosis secretion negative regulation of calcium ion-dependent exocytosis export from cell regulation of vesicle-mediated transport regulation of secretion exocytosis regulation of exocytosis regulation of body fluid levels cell activation hemostasis blood coagulation coagulation platelet activation regulation of potassium ion transport positive regulation of potassium ion transport positive regulation of transport positive regulation of monoatomic ion transport potassium ion transport adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway negative regulation of catabolic process lipid catabolic process catabolic process regulation of lipid metabolic process negative regulation of metabolic process regulation of catabolic process regulation of lipid catabolic process organic substance catabolic process negative regulation of lipid metabolic process negative regulation of lipid catabolic process lipid metabolic process positive regulation of membrane protein ectodomain proteolysis macromolecule catabolic process cellular catabolic process regulation of proteolysis proteolysis membrane protein proteolysis membrane protein ectodomain proteolysis organonitrogen compound catabolic process regulation of membrane protein ectodomain proteolysis protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of cellular catabolic process positive regulation of cellular catabolic process regulation of protein catabolic process small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette muscle contraction muscle system process regulation of muscle system process negative regulation of muscle contraction uterine smooth muscle contraction smooth muscle contraction regulation of smooth muscle contraction regulation of muscle contraction regulation of uterine smooth muscle contraction negative regulation of uterine smooth muscle contraction negative regulation of smooth muscle contraction negative regulation of multicellular organismal process chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication DNA metabolic process nucleic acid metabolic process multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process regulation of calcium ion transmembrane transporter activity negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport regulation of monoatomic ion transmembrane transporter activity negative regulation of transporter activity negative regulation of molecular function inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport regulation of monoatomic cation transmembrane transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport response to organic substance response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to organic substance cellular response to hormone stimulus protein localization negative regulation of protein transport establishment of protein localization nitrogen compound transport cellular macromolecule localization negative regulation of hormone secretion regulation of peptide hormone secretion negative regulation of peptide hormone secretion regulation of hormone levels organic substance transport establishment of protein localization to extracellular region negative regulation of establishment of protein localization protein secretion regulation of protein secretion negative regulation of protein secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion negative regulation of signaling hormone secretion negative regulation of cell communication protein localization to extracellular region negative regulation of peptide secretion peptide secretion amide transport signal release negative regulation of protein localization regulation of peptide transport regulation of establishment of protein localization regulation of protein transport peptide transport negative regulation of insulin secretion protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion Ras protein signal transduction cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation vasodilation regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of protein serine/threonine kinase activity regulation of intracellular signal transduction MAPK cascade establishment of localization in cell intracellular glucose homeostasis cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose insulin secretion involved in cellular response to glucose stimulus response to monosaccharide response to carbohydrate cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus negative regulation of response to stimulus negative regulation of insulin secretion involved in cellular response to glucose stimulus response to oxygen-containing compound cellular response to glucose stimulus response to hexose cellular homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion monoamine transport negative regulation of amine transport regulation of catecholamine secretion epinephrine secretion organic hydroxy compound transport catecholamine transport epinephrine transport regulation of epinephrine secretion negative regulation of catecholamine secretion organic cation transport catecholamine secretion amine transport negative regulation of epinephrine secretion regulation of amine transport cellular biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process cytokine production regulation of cytokine production regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production positive regulation of cellular biosynthetic process negative regulation of norepinephrine secretion norepinephrine transport norepinephrine secretion regulation of norepinephrine secretion	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region basal part of cell basal plasma membrane basolateral plasma membrane dopaminergic synapse intracellular anatomical structure cytoplasm glutamatergic synapse protein-containing complex receptor complex somatodendritic compartment cell body neuronal cell body GABA-ergic synapse presynaptic active zone membrane presynaptic membrane presynapse presynaptic active zone axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001946	Alpha 2A adrenoceptor	Family
A	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A	IPR002233	Adrenoceptor family	Family
A	IPR017452	GPCR, rhodopsin-like, 7TM	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08913	hypertensive disorder Fibrosis panic disorder asthma epilepsy heart disease attention deficit hyperactivity disorder, inattentive type depressive disorder ductal breast carcinoma in situ oligodendroglioma hydrolethalus syndrome pilocytic astrocytoma atypical teratoid rhabdoid tumor pulmonary emphysema breast fibroadenoma hypertensive disorder Fibrosis panic disorder asthma epilepsy heart disease attention deficit hyperactivity disorder, inattentive type depressive disorder ductal breast carcinoma in situ oligodendroglioma hydrolethalus syndrome pilocytic astrocytoma atypical teratoid rhabdoid tumor pulmonary emphysema breast fibroadenoma malignant ependymoma schizophrenia cerebrovascular disorder ocular hypertension open-angle glaucoma ovarian cancer glioblastoma Parkinson disease peripheral vascular disease alveolar capillary dysplasia with misalignment of pulmonary veins pituitary cancer invasive ductal breast carcinoma primitive neuroectodermal tumor bronchiectasis malignant glioma vascular disease cystic fibrosis familial partial lipodystrophy phaeochromocytoma anaphylaxis hypotensive disorder large cell medulloblastoma psoriasis lung cancer rosacea bronchitis medulloblastoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Peptides	Alpha-helical peptides	Peptides of transmembrane proteins	GPCR peptides

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.