1HAK

CRYSTAL STRUCTURE OF RECOMBINANT HUMAN PLACENTAL ANNEXIN V COMPLEXED WITH K-201 AS A CALCIUM CHANNEL ACTIVITY INHIBITOR

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d1hakb_	All alpha proteins	Annexin	Annexin	Annexin	Annexin V	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth A]	d1haka_	All alpha proteins	Annexin	Annexin	Annexin	Annexin V	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	Annexin	8037788	3000627	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	Annexin	8037788	3000627	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF00191	e1hakB2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)
B [auth A]	PF00191	e1hakA2	A: alpha arrays	X: Annexin (From Topology)	H: Annexin (From Topology)	T: Annexin	F: PF00191	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
B [auth A]	1.10.220.10	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth B], B [auth A]	ANNEXIN V	ANXA5	Homo sapiens (human)	ANXA5*01	R-LIKE-DOMAIN ANX1 (Pr7-87), R-LIKE-DOMAIN ANX2 (Pr88-159), R-LIKE-DOMAIN ANX3 (Pr160-243), R-LIKE-DOMAIN ANX4 (Pr244-320)	RPI	RPI-ANX	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00191	Annexin (Annexin)	Annexin	This family of annexins also includes giardin that has been shown to function as an annexin [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	ANNEXIN V	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipid binding lipid binding calcium-dependent phospholipid binding enzyme regulator activity molecular function inhibitor activity phospholipase inhibitor activity molecular function regulator activity enzyme inhibitor activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding phospholipid binding lipid binding calcium-dependent phospholipid binding enzyme regulator activity molecular function inhibitor activity phospholipase inhibitor activity molecular function regulator activity enzyme inhibitor activity lipase inhibitor activity modified amino acid binding phosphatidylserine binding	multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding response to organic substance response to chemical regulation of biological process multicellular organismal process regulation of body fluid levels wound healing response to stimulus hemostasis biological regulation blood coagulation response to stress coagulation regulation of biological quality response to wounding response to organic substance response to chemical regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular response to stimulus signaling signal transduction cell communication negative regulation of coagulation regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of coagulation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction endothelial microparticle extracellular region extracellular space blood microparticle cell periphery cell surface membrane plasma membrane external side of plasma membrane anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction endothelial microparticle extracellular region extracellular space blood microparticle cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol sarcolemma

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR001464	Annexin	Family
A [auth B], B [auth A]	IPR018252	Annexin repeat, conserved site	Conserved Site
A [auth B], B [auth A]	IPR037104	Annexin superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR018502	Annexin repeat	Repeat
A [auth B], B [auth A]	IPR002392	Annexin A5	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: P08758	pregnancy loss, recurrent, susceptibility to, 3 Wilson disease acute myeloid leukemia squamous cell carcinoma Liver Cirrhosis, Experimental preeclampsia IgA glomerulonephritis ulcerative colitis lung cancer lymphatic system disease medulloblastoma bone disease oral cavity neoplasm cancer ovarian disease pregnancy loss, recurrent, susceptibility to, 3 Wilson disease acute myeloid leukemia squamous cell carcinoma Liver Cirrhosis, Experimental preeclampsia IgA glomerulonephritis ulcerative colitis lung cancer lymphatic system disease medulloblastoma bone disease oral cavity neoplasm cancer ovarian disease Duchenne muscular dystrophy gastric neoplasm prostate disease subependymal giant cell astrocytoma intestinal disease uterine disease liver disease lung carcinoma malignant ependymoma astrocytic tumor breast carcinoma osteosarcoma Crohn disease pilocytic astrocytoma Emery-Dreifuss muscular dystrophy glioblastoma hereditary diffuse gastric adenocarcinoma tuberculosis juvenile dermatomyositis lung adenocarcinoma lung disease malignant glioma malignant pancreatic neoplasm atypical teratoid rhabdoid tumor myopathy breast disease ovarian cancer Down syndrome plasma cell myeloma gastric cancer hematologic disease stomach disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.