1H9D

Aml1/cbf-beta/dna complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1h9da_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	RUNT domain	Acute myeloid leukemia 1 protein (AML1), RUNT domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1h9dc_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	RUNT domain	Acute myeloid leukemia 1 protein (AML1), RUNT domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1h9dd_	All beta proteins	Core binding factor beta, CBF	Core binding factor beta, CBF	Core binding factor beta, CBF	Core binding factor beta, CBF	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1h9db_	All beta proteins	Core binding factor beta, CBF	Core binding factor beta, CBF	Core binding factor beta, CBF	Core binding factor beta, CBF	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	p53-like transcription factors	8043032	3000758	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	p53-like transcription factors	8043032	3000758	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Core binding factor beta CBF	8042548	3001169	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Core binding factor beta CBF	8042548	3001169	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Runt	e1h9dA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Runt	ECOD (1.6)
C	Runt	e1h9dC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: Runt	ECOD (1.6)
D	CBF_beta	e1h9dD1	A: beta barrels	X: CBF-like	H: Core binding factor beta, CBF (From Topology)	T: Core binding factor beta, CBF	F: CBF_beta	ECOD (1.6)
B	CBF_beta	e1h9dB1	A: beta barrels	X: CBF-like	H: Core binding factor beta, CBF (From Topology)	T: Core binding factor beta, CBF	F: CBF_beta	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.720	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
C	2.60.40.720	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.40.250.10	Mainly Beta	Beta Barrel	Polyomavirus Enhancer Binding Protein 2	Chain: A	CATH (4.3.0)
B	2.40.250.10	Mainly Beta	Beta Barrel	Polyomavirus Enhancer Binding Protein 2	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00853	Runt domain (Runt)	Runt domain	-	Domain
B, D	PF02312	Core binding factor beta subunit (CBF_beta)	Core binding factor beta subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	CORE-BINDING FACTOR ALPHA SUBUNIT1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding calcium ion binding metal ion binding transcription factor binding transcription coregulator binding transcription corepressor binding protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity identical protein binding protein homodimerization activity transcription coactivator binding DNA-binding transcription factor binding	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organismal process myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of granulocyte differentiation developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organismal process myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of granulocyte differentiation regulation of cellular process regulation of developmental process positive regulation of biological process regulation of cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development positive regulation of cell differentiation positive regulation of hemopoiesis regulation of immune system process regulation of multicellular organismal process positive regulation of immune system process positive regulation of cellular process regulation of biological process regulation of multicellular organismal development regulation of myeloid cell differentiation biological regulation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation granulocyte differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of granulocyte differentiation positive regulation of leukocyte differentiation leukocyte differentiation regulation of protein maturation cellular biosynthetic process protein maturation regulation of primary metabolic process organic substance metabolic process regulation of proteolysis proteolysis organic substance biosynthetic process regulation of plasminogen activation protein metabolic process plasminogen activation zymogen activation regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process tissue regeneration developmental growth cardiac muscle tissue regeneration growth regeneration ossification connective tissue development animal organ development tissue development skeletal system development chondrocyte differentiation cartilage development system development tissue remodeling regulation of connective tissue replacement connective tissue replacement regulation of tissue remodeling negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of metabolic process positive regulation of collagen metabolic process positive regulation of biosynthetic process positive regulation of collagen biosynthetic process collagen metabolic process positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process negative regulation of cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of developmental process negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of granulocyte differentiation negative regulation of immune system process negative regulation of multicellular organismal process nervous system development generation of neurons neurogenesis neuron differentiation regulation of leukocyte activation regulation of alpha-beta T cell activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation negative regulation of cell adhesion negative regulation of T cell differentiation T cell activation alpha-beta T cell activation T cell differentiation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of lymphocyte differentiation negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation regulation of alpha-beta T cell differentiation regulation of CD4-positive, alpha-beta T cell differentiation lymphocyte activation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation CD4-positive, alpha-beta T cell differentiation leukocyte cell-cell adhesion leukocyte activation regulation of T cell differentiation cell adhesion alpha-beta T cell differentiation cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of CD4-positive, alpha-beta T cell activation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation peripheral nervous system neuron development peripheral nervous system development peripheral nervous system neuron differentiation neuron development angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis regulation of cytokine production cytokine production regulation of interleukin-2 production interleukin-2 production positive regulation of interleukin-2 production positive regulation of gene expression positive regulation of cytokine production CD8-positive, alpha-beta T cell activation positive regulation of T cell differentiation positive regulation of CD8-positive, alpha-beta T cell activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of T cell activation positive regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell differentiation CD8-positive, alpha-beta T cell differentiation positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell adhesion positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell differentiation regulation of CD8-positive, alpha-beta T cell activation positive regulation of lymphocyte differentiation regulation of growth regulation of cardiac muscle tissue growth cardiac muscle cell proliferation organ growth striated muscle tissue development regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation heart development heart growth regulation of developmental growth cardiac muscle tissue development regulation of cell population proliferation regulation of cellular component organization positive regulation of cellular component organization positive regulation of extracellular matrix organization extracellular matrix organization cellular component organization cellular component organization or biogenesis regulation of extracellular matrix organization extracellular structure organization external encapsulating structure organization	intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle protein-containing complex intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex core-binding factor complex
B, D	CORE-BINDING FACTOR CBF-BETA	transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding nucleic acid binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation organonitrogen compound metabolic process protein polyubiquitination primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation immune system process anatomical structure development leukocyte differentiation cellular biosynthetic process cellular metabolic process RNA metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process definitive hemopoiesis regulation of cellular process regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process regulation of leukocyte differentiation CD8-positive, alpha-beta T cell activation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation regulation of cell differentiation positive regulation of T cell differentiation positive regulation of CD8-positive, alpha-beta T cell activation regulation of cell development positive regulation of developmental process positive regulation of cell activation multicellular organism development T cell activation positive regulation of leukocyte activation alpha-beta T cell activation regulation of immune system process T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development positive regulation of alpha-beta T cell activation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process positive regulation of alpha-beta T cell differentiation regulation of developmental process CD8-positive, alpha-beta T cell differentiation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion regulation of alpha-beta T cell differentiation leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion alpha-beta T cell differentiation cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell differentiation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process regulation of lymphocyte differentiation regulation of multicellular organismal development positive regulation of cell adhesion regulation of cell adhesion positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of T cell activation regulation of CD8-positive, alpha-beta T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation regulation of CD8-positive, alpha-beta T cell activation positive regulation of lymphocyte differentiation regulation of lymphocyte activation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process myeloid cell differentiation anatomical structure maturation cell maturation developmental maturation negative regulation of cell adhesion negative regulation of T cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of cell-cell adhesion negative regulation of lymphocyte differentiation negative regulation of multicellular organismal process negative regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of leukocyte activation regulation of CD4-positive, alpha-beta T cell differentiation negative regulation of alpha-beta T cell differentiation negative regulation of lymphocyte activation CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell activation negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell activation negative regulation of cell development regulation of CD4-positive, alpha-beta T cell activation negative regulation of immune system process negative regulation of alpha-beta T cell activation	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle core-binding factor complex organelle membrane membrane-enclosed lumen RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle core-binding factor complex organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
E, G	DNA (5'-(GPTPTPGPCPGPGPTPTPG)-3')	-	-	-
F, H	DNA (5'-(CPAPAPCPCPGPCPAPAPC)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, C	IPR013524	Runt domain	Domain
A, C	IPR016554	Runt-related transcription factor RUNX	Family
A, C	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, C	IPR000040	Acute myeloid leukemia 1 protein (AML1)/Runt	Family
A, C	IPR027384	Runx, central domain superfamily	Homologous Superfamily
A, C	IPR013711	Runx, C-terminal domain	Domain
B, D	IPR003417	Core-binding factor, beta subunit	Family
B, D	IPR036552	Core-binding factor, beta subunit superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q01196	rheumatoid arthritis glioblastoma acute myeloid leukemia juvenile myelomonocytic leukemia Precursor B-Cell Lymphoblastic Leukemia-Lymphoma prostate cancer myelodysplastic syndrome giant cell glioblastoma chronic myelogenous leukemia, BCR-ABL1 positive esophageal squamous cell carcinoma hereditary thrombocytopenia and hematologic cancer predisposition syndrome juvenile idiopathic arthritis gastric carcinoma tuberculosis hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 rheumatoid arthritis glioblastoma acute myeloid leukemia juvenile myelomonocytic leukemia Precursor B-Cell Lymphoblastic Leukemia-Lymphoma prostate cancer myelodysplastic syndrome giant cell glioblastoma chronic myelogenous leukemia, BCR-ABL1 positive esophageal squamous cell carcinoma hereditary thrombocytopenia and hematologic cancer predisposition syndrome juvenile idiopathic arthritis gastric carcinoma tuberculosis hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1 allergic rhinitis lung cancer asthma malignant ependymoma breast carcinoma ovarian cancer cancer pancreatic intraductal papillary-mucinous neoplasm chronic kidney disease platelet storage pool deficiency congenital anemia Down syndrome subependymal giant cell astrocytoma hematopoietic and lymphoid system neoplasm Hermansky-Pudlak syndrome 1 amyotrophic lateral sclerosis lung carcinoma malignant glioma atrial fibrillation myopathy breast fibroadenoma pancreatic ductal adenocarcinoma carcinoma of esophagus pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis systemic mastocytosis lung adenocarcinoma androgenetic alopecia malignant colon neoplasm malignant pancreatic neoplasm breast cancer osteosarcoma Burkitt lymphoma pancreatic intraductal papillary-mucinous carcinoma childhood acute lymphoblastic leukemia pilocytic astrocytoma chronic obstructive pulmonary disease
B, D	Pharos: Q13951	acute myeloid leukemia cleft palate acute myelomonocytic leukemia M4 Bone Diseases, Developmental malignant glioma myopathy ovarian cancer atypical teratoid rhabdoid tumor congenital heart disease glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma pilocytic astrocytoma large cell medulloblastoma malignant ependymoma acute myeloid leukemia cleft palate acute myelomonocytic leukemia M4 Bone Diseases, Developmental malignant glioma myopathy ovarian cancer atypical teratoid rhabdoid tumor congenital heart disease glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma pilocytic astrocytoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma ulcerative colitis amyotrophic lateral sclerosis cancer Down syndrome IgA glomerulonephritis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.