1H2D

Ebola virus matrix protein VP40 N-terminal domain in complex with RNA (Low-resolution VP40[31-212] variant).

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1h2da_	All beta proteins	EV matrix protein	EV matrix protein	EV matrix protein	EV matrix protein	(Ebola virus sp. ) [TaxId: 205488 ],	SCOPe (2.08)
B	d1h2db_	All beta proteins	EV matrix protein	EV matrix protein	EV matrix protein	EV matrix protein	(Ebola virus sp. ) [TaxId: 205488 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EV matrix protein-like	8044506	3000219	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EV matrix protein-like	8044506	3000219	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	VP40_N	e1h2dA1	A: beta barrels	X: EV matrix protein (From Homology)	H: EV matrix protein	T: EV matrix protein	F: VP40_N	ECOD (1.6)
B	VP40_N	e1h2dB1	A: beta barrels	X: EV matrix protein (From Homology)	H: EV matrix protein	T: EV matrix protein	F: VP40_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.20.20	Mainly Beta	Distorted Sandwich	Topoisomerase I	domain 3	CATH (4.3.0)
B	2.70.20.20	Mainly Beta	Distorted Sandwich	Topoisomerase I	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07447	Matrix protein VP40 (VP40)	Matrix protein VP40	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	MATRIX PROTEIN VP40	structural constituent of virion structural molecule activity RNA binding binding organic cyclic compound binding nucleic acid binding identical protein binding protein binding	response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host defenses response to host response to external biotic stimulus symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host defenses response to host response to external biotic stimulus symbiont-mediated perturbation of host defense response modulation by virus of host process virus-mediated perturbation of host defense response modulation by symbiont of host process viral process modulation of process of another organism modulation by virus of host cellular process non-lytic viral release viral budding viral life cycle virion assembly exit from host cell viral budding from plasma membrane viral release from host cell symbiont-mediated perturbation of host immune response symbiont-mediated suppression of host RNAi-mediated antiviral immune response symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response response to host immune response symbiont-mediated perturbation of host innate immune response viral budding via host ESCRT complex intracellular transport of virus transport of virus	host cellular component host cell endomembrane system host cell part host cell membrane cellular anatomical entity virion component virion membrane extracellular region host intracellular membrane-bounded organelle host intracellular part host cell cytoplasm part host cell late endosome membrane host intracellular organelle host cell cytoplasm host cellular component host cell endomembrane system host cell part host cell membrane cellular anatomical entity virion component virion membrane extracellular region host intracellular membrane-bounded organelle host intracellular part host cell cytoplasm part host cell late endosome membrane host intracellular organelle host cell cytoplasm host cell endosome membrane host cell late endosome host cell endosome host intracellular region membrane microdomain membrane raft membrane host cell plasma membrane protein-containing complex ribonucleoprotein complex
C [auth R], D [auth S]	5'-R(UPGP*AP)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR043079	EV matrix protein, N-terminal	Homologous Superfamily
A, B	IPR008986	EV matrix protein	Family
A, B	IPR038057	EV matrix domain superfamily	Homologous Superfamily
A, B	IPR035092	EV matrix protein, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.