1GXD

proMMP-2/TIMP-2 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gxda1	All alpha proteins	PGBD-like	PGBD-like	MMP N-terminal domain	Gelatinase A (MMP-2)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1gxda2	All beta proteins	4-bladed beta-propeller	Hemopexin-like domain	Hemopexin-like domain	Gelatinase A (MMP-2), C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1gxda3	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Matrix metalloproteases, catalytic domain	Gelatinase A	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1gxda4	Small proteins	Kringle-like	Kringle-like	Fibronectin type II module	Gelatinase A (MMP-2) type II modules	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1gxdb1	All alpha proteins	PGBD-like	PGBD-like	MMP N-terminal domain	Gelatinase A (MMP-2)	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1gxdb2	All beta proteins	4-bladed beta-propeller	Hemopexin-like domain	Hemopexin-like domain	Gelatinase A (MMP-2), C-terminal domain	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1gxdb3	Alpha and beta proteins (a+b)	Zincin-like	Metalloproteases ('zincins'), catalytic domain	Matrix metalloproteases, catalytic domain	Gelatinase A	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1gxdb4	Small proteins	Kringle-like	Kringle-like	Fibronectin type II module	Gelatinase A (MMP-2) type II modules	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1gxdd_	All beta proteins	OB-fold	TIMP-like	Tissue inhibitor of metalloproteinases, TIMP	TIMP-2	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1gxdc_	All beta proteins	OB-fold	TIMP-like	Tissue inhibitor of metalloproteinases, TIMP	TIMP-2	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8091369	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8091369	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Kringle-like	8038598	3000761	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Kringle-like	8038594	3000761	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Kringle-like	8038597	3000761	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Hemopexin-like domain	8042812	3001566	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PGBD-like	8038587	3001357	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Hemopexin-like domain	8042812	3001566	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Kringle-like	8038598	3000761	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Kringle-like	8038594	3000761	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8091369	3001975	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PGBD-like	8038587	3001357	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8091369	3001975	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Kringle-like	8038597	3000761	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TIMP-like	8041907	3000488	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TIMP-like	8041907	3000488	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hemopexin	e1gxdA5	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 4-bladed	F: Hemopexin	ECOD (1.6)
A	PG_binding_1	e1gxdA4	A: alpha arrays	X: PGBD-like (From Topology)	H: PGBD-like (From Topology)	T: PGBD-like	F: PG_binding_1	ECOD (1.6)
A	Peptidase_M10	e1gxdA3	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M10	ECOD (1.6)
A	fn2	e1gxdA1	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: fn2	ECOD (1.6)
B	Hemopexin	e1gxdB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 4-bladed	F: Hemopexin	ECOD (1.6)
B	PG_binding_1	e1gxdB2	A: alpha arrays	X: PGBD-like (From Topology)	H: PGBD-like (From Topology)	T: PGBD-like	F: PG_binding_1	ECOD (1.6)
B	Peptidase_M10	e1gxdB6	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M10	ECOD (1.6)
B	fn2	e1gxdB3	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: fn2	ECOD (1.6)
D	TIMP	e1gxdD1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: TIMP	ECOD (1.6)
C	TIMP	e1gxdC1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: TIMP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
A	2.10.10.10	Mainly Beta	Ribbon	Seminal Fluid Protein PDC-109 (Domain B)	Fibronectin, type II, collagen-binding	CATH (4.3.0)
A	2.110.10.10	Mainly Beta	4 Propeller	Hemopexin	Hemopexin-like domain	CATH (4.3.0)
B	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
B	2.10.10.10	Mainly Beta	Ribbon	Seminal Fluid Protein PDC-109 (Domain B)	Fibronectin, type II, collagen-binding	CATH (4.3.0)
B	2.110.10.10	Mainly Beta	4 Propeller	Hemopexin	Hemopexin-like domain	CATH (4.3.0)
D	3.90.370.10	Alpha Beta	Alpha-Beta Complex	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	CATH (4.3.0)
D	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
C	3.90.370.10	Alpha Beta	Alpha-Beta Complex	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	Tissue inhibitor of metalloproteinase-1. Chain B, domain 1	CATH (4.3.0)
C	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00413	Matrixin (Peptidase_M10)	Matrixin	The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.	Domain
A, B	PF00040	Fibronectin type II domain (fn2)	Fibronectin type II domain	-	Domain
A, B	PF00045	Hemopexin (Hemopexin)	Hemopexin	-	Repeat
C, D	PF00965	Tissue inhibitor of metalloproteinase (TIMP)	Tissue inhibitor of metalloproteinase	Members of this family are common in extracellular regions of vertebrate species	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	72 KDA TYPE IV COLLAGENASE	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity protein binding binding fibronectin binding metalloendopeptidase activity cation binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity protein binding binding fibronectin binding metalloendopeptidase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of tube diameter regulation of biological process system process response to stimulus response to chemical response to xenobiotic stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of tube diameter regulation of biological process system process regulation of tube size regulation of system process negative regulation of biological process biological regulation negative regulation of vasoconstriction circulatory system process regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction regulation of multicellular organismal process blood vessel diameter maintenance regulation of biological quality negative regulation of multicellular organismal process vasoconstriction blood circulation regulation of anatomical structure size cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular process signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process multi-multicellular organism process reproductive process parturition multi-organism reproductive process ossification direct ossification intramembranous ossification response to electrical stimulus response to abiotic stimulus gonad development reproductive system development female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction development of primary sexual characteristics reproductive structure development ovarian follicle development cellular response to stress response to stress response to fluid shear stress cellular response to fluid shear stress ovulation cycle process ovulation sexual reproduction female gamete generation gamete generation ovulation from ovarian follicle ovulation cycle rhythmic process multicellular organismal reproductive process cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to organic substance cellular response to chemical stimulus response to amino acid response to decreased oxygen levels response to hypoxia response to oxygen levels epithelium development prostate gland development gland development morphogenesis of an epithelium urogenital system development tissue development prostate gland epithelium morphogenesis prostate gland morphogenesis tissue morphogenesis anatomical structure morphogenesis gland morphogenesis animal organ morphogenesis response to hydrogen peroxide response to oxidative stress response to oxygen-containing compound response to reactive oxygen species response to inorganic substance response to cytokine cellular response to interleukin-1 cellular response to cytokine stimulus cellular response to organic substance response to interleukin-1 blood vessel maturation developmental maturation vasculature development anatomical structure maturation blood vessel development cell adhesion regulation of cell adhesion negative regulation of cellular process negative regulation of cell adhesion positive regulation of cell communication intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process positive regulation of signal transduction regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of biological process regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intracellular signal transduction positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process positive regulation of cellular process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway regulation of response to stimulus positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of neuron apoptotic process regulation of apoptotic signaling pathway positive regulation of signaling collagen catabolic process collagen metabolic process response to hormone response to endogenous stimulus response to estrogen cellular developmental process cell projection organization cell development neuron projection development regeneration response to axon injury neuron projection regeneration neurogenesis axon regeneration neuron differentiation cell differentiation response to wounding peripheral nervous system axon regeneration plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development blood vessel morphogenesis tube development angiogenesis tube morphogenesis anatomical structure formation involved in morphogenesis head development face morphogenesis head morphogenesis face development body morphogenesis formation of primary germ layer embryonic morphogenesis embryo development gastrulation endoderm development endoderm formation endodermal cell differentiation response to activity bone trabecula formation skeletal system development bone trabecula morphogenesis skeletal system morphogenesis trabecula formation trabecula morphogenesis regulation of vascular associated smooth muscle cell proliferation cell population proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation tissue remodeling response to retinoic acid response to lipid cellular component disassembly extracellular matrix disassembly female pregnancy embryo implantation response to organonitrogen compound response to nitrogen compound response to amyloid-beta response to mechanical stimulus response to external stimulus cellular response to oxidative stress cellular response to chemical stress cellular response to oxygen-containing compound cellular response to reactive oxygen species positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cell chemotaxis chemotaxis macrophage chemotaxis macrophage migration leukocyte migration taxis immune system process mononuclear cell migration myeloid leukocyte migration leukocyte chemotaxis cellular response to organic cyclic compound cellular response to lipid response to estradiol cellular response to estradiol stimulus response to organic cyclic compound response to nicotine response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to UV-A cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV response to UV-A proteolysis luteinization response to hyperoxia response to increased oxygen levels	cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cellular anatomical entity intracellular anatomical structure sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle extracellular region extracellular space membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle plasma membrane membrane nucleus
C, D	METALLOPROTEINASE INHIBITOR 2	molecular function inhibitor activity molecular function regulator activity enzyme regulator activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity protein binding binding enzyme binding protease binding cation binding transition metal ion binding zinc ion binding ion binding molecular function inhibitor activity molecular function regulator activity enzyme regulator activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity protein binding binding enzyme binding protease binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity	negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process negative regulation of peptidase activity organic substance metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of primary metabolic process negative regulation of peptidase activity organic substance metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of peptidase activity biological regulation negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process regulation of molecular function regulation of metallopeptidase activity regulation of hydrolase activity negative regulation of metallopeptidase activity metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of membrane protein ectodomain proteolysis negative regulation of cellular catabolic process catabolic process regulation of cellular process macromolecule catabolic process negative regulation of cellular metabolic process negative regulation of protein catabolic process cellular catabolic process membrane protein proteolysis negative regulation of cellular process membrane protein ectodomain proteolysis organonitrogen compound catabolic process negative regulation of catabolic process regulation of membrane protein ectodomain proteolysis cellular metabolic process regulation of cellular metabolic process regulation of catabolic process protein catabolic process regulation of cellular catabolic process cellular process organic substance catabolic process regulation of protein catabolic process response to organic substance response to stimulus response to chemical response to cytokine response to hormone response to endogenous stimulus	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space ficolin-1-rich granule ficolin-1-rich granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR021158	Peptidase M10A, cysteine switch, zinc binding site	Binding Site
A, B	IPR000562	Fibronectin type II domain	Domain
A, B	IPR021190	Peptidase M10A	Family
A, B	IPR006026	Peptidase, metallopeptidase	Domain
A, B	IPR033739	Peptidase M10A, catalytic domain	Domain
A, B	IPR018486	Hemopexin, conserved site	Conserved Site
A, B	IPR036375	Hemopexin-like domain superfamily	Homologous Superfamily
A, B	IPR036943	Fibronectin type II domain superfamily	Homologous Superfamily
A, B	IPR036365	PGBD-like superfamily	Homologous Superfamily
A, B	IPR001818	Peptidase M10, metallopeptidase	Domain
A, B	IPR013806	Kringle-like fold	Homologous Superfamily
A, B	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A, B	IPR018487	Hemopexin-like repeats	Repeat
A, B	IPR000585	Hemopexin-like domain	Domain
C, D	IPR027465	Proteinase inhibitor I35b (TIMP), C-terminal	Homologous Superfamily
C, D	IPR001134	Netrin domain	Domain
C, D	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
C, D	IPR030490	Tissue inhibitor of metalloproteinase, conserved site	Conserved Site
C, D	IPR001820	Protease inhibitor I35 (TIMP)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P08253	Marfan syndrome glioblastoma rheumatoid arthritis thoracic aortic aneurysm oral submucous fibrosis nasopharyngeal carcinoma testicular germ cell tumor breast carcinoma extrahepatic cholestasis cirrhosis of liver myocardial infarction aortic aneurysm Neointima diabetic polyneuropathy lupus nephritis Marfan syndrome glioblastoma rheumatoid arthritis thoracic aortic aneurysm oral submucous fibrosis nasopharyngeal carcinoma testicular germ cell tumor breast carcinoma extrahepatic cholestasis cirrhosis of liver myocardial infarction aortic aneurysm Neointima diabetic polyneuropathy lupus nephritis bone disease pulmonary emphysema colorectal cancer alcoholic liver cirrhosis osteosarcoma calcinosis pulmonary fibrosis giant cell glioblastoma multicentric osteolysis, nodulosis, and arthropathy hypertensive disorder cutaneous leishmaniasis aortic disease diabetic autonomic neuropathy diabetic neuropathy bone cancer malignant glioma pancreatic intraductal papillary-mucinous carcinoma drug-induced liver injury malignant pancreatic neoplasm pilocytic astrocytoma cancer psoriasis adrenal cortex adenoma subependymal giant cell astrocytoma hypospadias interstitial lung disease cystic fibrosis ulcerative colitis intracerebral hemorrhage X-linked mixed deafness with perilymphatic gusher lung cancer malignant mesothelioma pancreatic intraductal papillary-mucinous neoplasm Duchenne muscular dystrophy malignant tumor of nasopharynx breast disease primitive neuroectodermal tumor fetal growth restriction stomach disease adrenal cortex carcinoma hepatocellular carcinoma idiopathic interstitial pneumonia Torg-Winchester syndrome intervertebral disc degenerative disorder diabetes mellitus Kienbock disease atopic eczema lung carcinoma Becker muscular dystrophy pancreatic ductal adenocarcinoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Emery-Dreifuss muscular dystrophy prostate disease medulloblastoma alcohol abuse colorectal carcinoma nasopharyngeal neoplasm intestinal disease astrocytic tumor oligodendroglioma liver disease atypical teratoid rhabdoid tumor osteonecrosis lung disease ovarian cancer
C, D	Pharos: P16035	calcinosis extrahepatic cholestasis Occupational Diseases myocardial infarction pleural disease juvenile dermatomyositis lung cancer malignant glioma medulloblastoma myopathy atopic eczema pancreatic ductal adenocarcinoma Becker muscular dystrophy pilocytic astrocytoma primitive neuroectodermal tumor calcinosis extrahepatic cholestasis Occupational Diseases myocardial infarction pleural disease juvenile dermatomyositis lung cancer malignant glioma medulloblastoma myopathy atopic eczema pancreatic ductal adenocarcinoma Becker muscular dystrophy pilocytic astrocytoma primitive neuroectodermal tumor Duchenne muscular dystrophy ulcerative colitis glioblastoma limb-girdle muscular dystrophy lung carcinoma malignant mesothelioma atrial fibrillation pancreatic intraductal papillary-mucinous carcinoma pituitary cancer breast cancer Sjogren syndrome cancer subependymal giant cell astrocytoma Emery-Dreifuss muscular dystrophy facioscapulohumeral muscular dystrophy invasive ductal breast carcinoma malignant ependymoma malignant pancreatic neoplasm ovarian cancer atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast fibroadenoma eosinophilic esophagitis gastric carcinoma

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D	OPM	Monotopic/peripheral	Alpha + Beta monotopic/peripheral	PGBD superfamily	Putative peptidoglycan binding domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.