Annotations: 1GQE

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gqea_	Multi-domain proteins (alpha and beta)	Release factor	Release factor	Release factor	Polypeptide chain release factor 2 (RF2)	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Peptidyl-tRNA hydrolase domain	8054400	4002570	SCOP2 (2022-06-29)
A	SCOP2 Family	PCRF domain-like	8026433	4002864	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Peptidyl-tRNA hydrolase domain-like	8054401	3001421	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RNA-binding domain RBD	8054399	3000110	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Release factor N-terminal domain-like	8038812	3001827	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PCRF_N_1	e1gqeA1	A: alpha bundles	X: Release factor (Pfam 00472) N-terminal alpha helical domain (From Topology)	H: Release factor (Pfam 00472) N-terminal alpha helical domain (From Topology)	T: Release factor (Pfam 00472) N-terminal alpha helical domain	F: PCRF_N_1	ECOD (1.6)
A	PCRF_C	e1gqeA2	A: a+b two layers	X: Alpha-beta plaits	H: Ferredoxin-like domain in release factor (From Topology)	T: Ferredoxin-like domain in release factor	F: PCRF_C	ECOD (1.6)
A	RF-1_N	e1gqeA3	A: a+b two layers	X: dsRBD-like	H: Peptidyl-tRNA hydrolase domain-like (From Topology)	T: Peptidyl-tRNA hydrolase domain-like	F: RF-1_N	ECOD (1.6)
A	RF-1_C	e1gqeA4	A: a+b two layers	X: dsRBD-like	H: Peptidyl-tRNA hydrolase domain-like (From Topology)	T: Peptidyl-tRNA hydrolase domain-like	F: RF-1_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.58.410	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	3.30.70.1660	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
A	3.30.160.20	Alpha Beta	2-Layer Sandwich	Double Stranded RNA Binding Domain		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03462	PCRF domain (PCRF)	PCRF domain	This domain is found in peptide chain release factors.	Domain
A	PF00472	RF-1 domain (RF-1)	RF-1 domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RELEASE FACTOR 2	translation release factor activity, codon specific translation regulator activity binding organic cyclic compound binding translation regulator activity, nucleic acid binding translation release factor activity nucleic acid binding translation termination factor activity translation factor activity, RNA binding	cellular component disassembly organonitrogen compound metabolic process protein-containing complex organization cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process protein-containing complex disassembly primary metabolic process translation gene expression macromolecule biosynthetic process cellular component organization organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular component disassembly organonitrogen compound metabolic process protein-containing complex organization cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process protein-containing complex disassembly primary metabolic process translation gene expression macromolecule biosynthetic process cellular component organization organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular process metabolic process translational termination cellular component organization or biogenesis protein metabolic process macromolecule metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004374	Peptide chain release factor 2	Family
A	IPR000352	Peptide chain release factor class I	Domain
A	IPR045853	Peptide chain release factor class I superfamily	Homologous Superfamily
A	IPR005139	Peptide chain release factor	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.