Annotations: 1GPJ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gpja1	All alpha proteins	Glutamyl tRNA-reductase dimerization domain	Glutamyl tRNA-reductase dimerization domain	Glutamyl tRNA-reductase dimerization domain	Glutamyl tRNA-reductase dimerization domain	(Methanopyrus kandleri ) [TaxId: 2320 ],	SCOPe (2.08)
A	d1gpja2	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Aminoacid dehydrogenase-like, C-terminal domain	Glutamyl tRNA-reductase middle domain	(Methanopyrus kandleri ) [TaxId: 2320 ],	SCOPe (2.08)
A	d1gpja3	Alpha and beta proteins (a+b)	Ferredoxin-like	Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase catalytic, N-terminal domain	Glutamyl tRNA-reductase catalytic, N-terminal domain	(Methanopyrus kandleri ) [TaxId: 2320 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Glutamyl tRNA-reductase-like	8001493	4000132	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glutamyl tRNA-reductase dimerization domain	8091374	3000027	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Glutamyl tRNA-reductase coenzyme-binding domain-like	8001494	3000056	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Eukaryotic type KH-domain (KH-domain type I)	8001497	3001023	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GlutR_dimer	e1gpjA1	A: alpha duplicates or obligate multimers	X: Glutamyl tRNA-reductase dimerization domain (From Topology)	H: Glutamyl tRNA-reductase dimerization domain (From Topology)	T: Glutamyl tRNA-reductase dimerization domain	F: GlutR_dimer	ECOD (1.6)
A	GlutR_N	e1gpjA2	A: a+b two layers	X: Alpha-beta plaits	H: Glutamyl tRNA-reductase catalytic, N-terminal domain (From Topology)	T: Glutamyl tRNA-reductase catalytic, N-terminal domain	F: GlutR_N	ECOD (1.6)
A	Shikimate_DH	e1gpjA3	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: Shikimate_DH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.460.30	Alpha Beta	2-Layer Sandwich	Beta Polymerase	domain 2	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
A	1.10.1200.70	Mainly Alpha	Orthogonal Bundle	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00745	Glutamyl-tRNAGlu reductase, dimerisation domain (GlutR_dimer)	Glutamyl-tRNAGlu reductase, dimerisation domain	-	Domain
A	PF05201	Glutamyl-tRNAGlu reductase, N-terminal domain (GlutR_N)	Glutamyl-tRNAGlu reductase, N-terminal domain	-	Domain
A	PF01488	Shikimate / quinate 5-dehydrogenase (Shikimate_DH)	Shikimate / quinate 5-dehydrogenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Glutamyl-tRNA reductase	binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity catalytic activity, acting on RNA oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity, acting on a nucleic acid glutamyl-tRNA reductase activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity catalytic activity, acting on RNA oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity, acting on a nucleic acid glutamyl-tRNA reductase activity catalytic activity, acting on a tRNA catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process pigment metabolic process heme metabolic process porphyrin-containing compound biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process heme biosynthetic process protoporphyrinogen IX metabolic process organonitrogen compound biosynthetic process pigment biosynthetic process organic cyclic compound metabolic process protoporphyrinogen IX biosynthetic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process metabolic process porphyrin-containing compound metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR018214	Glutamyl-tRNA reductase, conserved site	Conserved Site
A	IPR006151	Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase	Domain
A	IPR036343	Glutamyl-tRNA reductase, N-terminal domain superfamily	Homologous Superfamily
A	IPR015895	Glutamyl-tRNA reductase, N-terminal	Domain
A	IPR015896	Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain	Domain
A	IPR000343	Glutamyl-tRNA reductase	Family
A	IPR036453	Glutamyl tRNA-reductase dimerization domain superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	glutamyl-tRNA reductase M-CSA #804	Glutamyl-tRNA Reductase catalyses the reduction of the activated alpha-carboxyl group of glutamate from glutamyl-tRNA using NADPH to form glutamate-1-semialdehyde(GSA). GSA is then converted to 5-aminolevulenic acid, a precursor molecule for the biosynthesis of tetrapyrroles like chlorophylls, hemes and coenzyme B12.	Defined by 2 residues: SER:A-48HIS:A-84 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.2.1.70 (PDB Primary Data) Search M-CSA Motif + EC 1.2.1.70

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