Annotations: 1GH6

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gh6a1	All alpha proteins	Long alpha-hairpin	Chaperone J-domain	Chaperone J-domain	Large T antigen, the N-terminal J domain	SV40 (Betapolyomavirus macacae ) [TaxId: 1891767 ],	SCOPe (2.08)
A	d1gh6a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	SV40 (Betapolyomavirus macacae ) [TaxId: 1891767 ],	SCOPe (2.08)
B	d1gh6b1	All alpha proteins	Cyclin-like	Cyclin-like	Retinoblastoma tumor suppressor domains	Retinoblastoma tumor suppressor domains	Human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chaperone J-domain	8023475	4000605	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Chaperone J-domain	8035855	3000721	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Cyclin-like	8044065	3000768	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cyclin-like	8044063	3000768	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DnaJ	e1gh6A1	A: alpha bundles	X: Chaperone J-domain (From Topology)	H: Chaperone J-domain (From Topology)	T: Chaperone J-domain	F: DnaJ	ECOD (1.6)
B	RB_A	e1gh6B2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: RB_A	ECOD (1.6)
B	RB_B	e1gh6B1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: RB_B	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.110	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	DnaJ domain	CATH (4.3.0)
B	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF01857	Retinoblastoma-associated protein B domain (RB_B)	Retinoblastoma-associated protein B domain	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1]. The B dom ...	The crystal structure of the Rb pocket bound to a nine-residue E7 peptide containing the LxCxE motif, shared by other Rb-binding viral and cellular proteins, shows that the LxCxE peptide binds a highly conserved groove on the B domain [1]. The B domain has a cyclin fold.	Domain
B	PF01858	Retinoblastoma-associated protein A domain (RB_A)	Retinoblastoma-associated protein A domain	This domain has the cyclin fold [1] as predicted [2].	Domain
B	PF08934	Rb C-terminal domain (Rb_C)	Rb C-terminal domain	The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a stra ...	The Rb C-terminal domain is required for high-affinity binding to E2F-DP complexes and for maximal repression of E2F-responsive promoters, thereby acting as a growth suppressor by blocking the G1-S transition of the cell cycle. This domain has a strand-loop-helix structure, which directly interacts with both E2F1 and DP1, followed by a tail segment that lacks regular secondary structure [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Large T antigen	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity hydrolase activity adenyl ribonucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity hydrolase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding identical protein binding protein binding single-stranded DNA binding	cellular biosynthetic process cellular metabolic process viral DNA genome replication primary metabolic process viral life cycle DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process viral genome replication cellular biosynthetic process cellular metabolic process viral DNA genome replication primary metabolic process viral life cycle DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process nucleic acid biosynthetic process organic substance metabolic process biosynthetic process viral genome replication organic cyclic compound biosynthetic process organic substance biosynthetic process viral process metabolic process cellular process macromolecule metabolic process DNA biosynthetic process symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host JAK-STAT cascade biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway modulation by symbiont of host process symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host cell cycle progression symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint bidirectional double-stranded viral DNA replication symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated perturbation of host ubiquitin-like protein modification DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization DNA replication cellular component organization or biogenesis	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle
B	Retinoblastoma-associated protein	phosphoprotein binding protein binding binding molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding phosphoprotein binding protein binding binding molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding kinase binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity importin-alpha family protein binding disordered domain specific binding protein domain specific binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation cell division multicellular organismal process regulation of cellular process regulation of developmental process negative regulation of biological process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis negative regulation of cellular process regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development regulation of multicellular organismal development regulation of biological process negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process biological regulation nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process protein localization localization cellular localization protein localization to chromosome, centromeric region protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death glial cell apoptotic process negative regulation of cell cycle cell cycle regulation of cell cycle establishment of organelle localization attachment of spindle microtubules to kinetochore sister chromatid biorientation chromosome organization sister chromatid segregation establishment of localization cellular component organization metaphase chromosome alignment organelle organization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular component organization or biogenesis establishment of chromosome localization chromosome segregation cell cycle process regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding positive regulation of transcription regulatory region DNA binding regulation of transcription regulatory region DNA binding positive regulation of binding positive regulation of DNA binding homeostatic process hemopoiesis erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process homeostasis of number of cells myeloid cell homeostasis enucleate erythrocyte differentiation erythrocyte homeostasis mitotic sister chromatid cohesion sister chromatid cohesion maintenance of sister chromatid cohesion maintenance of mitotic sister chromatid cohesion negative regulation of hepatocyte apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death epithelial cell apoptotic process negative regulation of apoptotic process regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process hepatocyte apoptotic process regulation of centromere complex assembly protein-containing complex organization protein-DNA complex assembly regulation of chromosome organization regulation of cellular component biogenesis regulation of organelle organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly centromere complex assembly skeletal muscle cell differentiation skeletal muscle tissue development animal organ development tissue development skeletal muscle organ development muscle tissue development muscle organ development regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of kinase activity negative regulation of protein phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process organic substance metabolic process protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process negative regulation of molecular function negative regulation of protein kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation cellular biosynthetic process RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of biological process mononuclear cell differentiation positive regulation of developmental process positive regulation of cell differentiation positive regulation of hemopoiesis regulation of immune system process regulation of macrophage differentiation positive regulation of immune system process positive regulation of cellular process regulation of myeloid cell differentiation positive regulation of cell development macrophage differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation leukocyte differentiation cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus striated muscle cell differentiation muscle cell differentiation connective tissue development skeletal system development chondrocyte differentiation cartilage development negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of biosynthetic process regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process plasma membrane bounded cell projection organization cell projection organization neuron projection development generation of neurons neuron differentiation neuron development cell surface receptor signaling pathway signaling smoothened signaling pathway cell communication signal transduction negative regulation of DNA-binding transcription factor activity regulation of DNA-binding transcription factor activity regulation of mitotic cell cycle positive regulation of organelle organization regulation of cell cycle phase transition regulation of mitotic nuclear division positive regulation of mitotic nuclear division positive regulation of mitotic metaphase/anaphase transition positive regulation of mitotic cell cycle phase transition mitotic sister chromatid separation regulation of cell cycle process positive regulation of nuclear division regulation of mitotic cell cycle phase transition regulation of chromosome separation regulation of chromosome segregation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic sister chromatid separation positive regulation of cellular component organization regulation of mitotic metaphase/anaphase transition positive regulation of metaphase/anaphase transition of cell cycle mitotic sister chromatid segregation positive regulation of cell cycle process positive regulation of mitotic cell cycle mitotic nuclear division organelle fission positive regulation of cell cycle nuclear division chromosome separation regulation of sister chromatid segregation positive regulation of cell cycle phase transition positive regulation of mitotic sister chromatid separation regulation of nuclear division metaphase/anaphase transition of mitotic cell cycle positive regulation of chromosome separation metaphase/anaphase transition of cell cycle developmental maturation anatomical structure maturation neuron maturation cell maturation digestive system development tube development digestive tract development regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response negative regulation of signaling regulation of signal transduction negative regulation of cell communication negative regulation of smoothened signaling pathway regulation of smoothened signaling pathway regulation of signaling negative regulation of signal transduction regulation of cell communication small GTPase-mediated signal transduction Ras protein signal transduction intracellular signal transduction intracellular signaling cassette heart development heart valve development aortic valve development circulatory system development anatomical structure morphogenesis heart valve morphogenesis semi-lunar valve development aortic valve morphogenesis cell morphogenesis involved in neuron differentiation cell morphogenesis negative regulation of apoptotic signaling pathway apoptotic signaling pathway regulation of apoptotic signaling pathway neuron apoptotic process regulation of cell cycle G1/S phase transition negative regulation of mitotic cell cycle negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of G1/S transition of mitotic cell cycle regulation of protein serine/threonine kinase activity negative regulation of protein serine/threonine kinase activity chromatin organization chromatin remodeling heterochromatin formation epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic anatomical structure homeostasis tissue homeostasis negative regulation of tau-protein kinase activity regulation of tau-protein kinase activity cellular response to nitrogen compound response to organic substance response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to organonitrogen compound response to hormone response to insulin cellular response to organic substance cellular response to insulin stimulus cellular response to hormone stimulus regulation of myofibroblast differentiation myofibroblast differentiation negative regulation of myofibroblast differentiation negative regulation of cold-induced thermogenesis adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis regulation of lipid kinase activity positive regulation of collagen fibril organization positive regulation of extracellular matrix organization collagen fibril organization extracellular matrix organization positive regulation of supramolecular fiber organization regulation of supramolecular fiber organization supramolecular fiber organization regulation of extracellular matrix organization regulation of collagen fibril organization extracellular structure organization external encapsulating structure organization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle SWI/SNF complex ATPase complex protein-containing complex catalytic complex protein-DNA complex nucleus nuclear protein-containing complex chromatin chromosome intracellular membrane-bounded organelle intracellular organelle organelle intracellular non-membrane-bounded organelle SWI/SNF superfamily-type complex non-membrane-bounded organelle cytoskeleton spindle microtubule cytoskeleton chromatin silencing complex chromatin lock complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen RNA polymerase II transcription regulator complex transcription regulator complex Rb-E2F complex nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001623	DnaJ domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR017910	Zinc finger, large T-antigen D1-type	Domain
A	IPR003133	T antigen, Ori-binding	Domain
A	IPR037102	Zinc finger, large T-antigen D1 domain superfamily	Homologous Superfamily
A	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily
A	IPR014015	Helicase, superfamily 3, DNA virus	Domain
A	IPR016392	Large T antigen, polyomaviridae	Family
A	IPR010932	Large T antigen, polyomavirus, C-terminal	Domain
B	IPR024599	Retinoblastoma-associated protein, N-terminal	Domain
B	IPR015030	Retinoblastoma-associated protein, C-terminal	Domain
B	IPR002720	Retinoblastoma-associated protein, A-box	Domain
B	IPR028309	Retinoblastoma protein family	Family
B	IPR002719	Retinoblastoma-associated protein, B-box	Domain
B	IPR036915	Cyclin-like superfamily	Homologous Superfamily
B	IPR013763	Cyclin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P06400	urinary bladder cancer small cell lung carcinoma osteosarcoma retinoblastoma chromosome 13q14 deletion syndrome esophageal squamous cell carcinoma non-small cell lung carcinoma adrenal cortex carcinoma hereditary retinoblastoma skin basal cell carcinoma Stevens-Johnson syndrome gastrointestinal stromal tumor prostate cancer Liver Neoplasms, Experimental Sezary syndrome urinary bladder cancer small cell lung carcinoma osteosarcoma retinoblastoma chromosome 13q14 deletion syndrome esophageal squamous cell carcinoma non-small cell lung carcinoma adrenal cortex carcinoma hereditary retinoblastoma skin basal cell carcinoma Stevens-Johnson syndrome gastrointestinal stromal tumor prostate cancer Liver Neoplasms, Experimental Sezary syndrome brain ischemia breast carcinoma small cell carcinoma sarcomatoid carcinoma bone osteosarcoma breast cancer carcinoma undifferentiated carcinoma childhood acute lymphoblastic leukemia myopathy urinary bladder neoplasm dermatomyositis oligodendroglioma adrenal gland cancer hypotrichosis 8 rheumatoid arthritis large cell medulloblastoma bladder benign neoplasm malignant mesothelioma skin pigmented basal cell carcinoma malignant pancreatic neoplasm mammary neoplasms, animal medulloblastoma cholangiocarcinoma eye disease glioblastoma adrenal carcinoma IgA glomerulonephritis sarcoma astrocytic tumor lung cancer Sjogren syndrome bladder carcinoma in situ breast adenocarcinoma cancer toxic epidermal necrolysis urinary bladder carcinoma pancreatic neoplasm hepatocellular carcinoma primitive neuroectodermal tumor juvenile dermatomyositis atypical teratoid rhabdoid tumor malignant ependymoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.