1GEF

Crystal structure of the archaeal holliday junction resolvase HJC

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1gefa_	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	Hjc-like	Archaeal Holliday junction resolvase Hjc	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
B	d1gefb_	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	Hjc-like	Archaeal Holliday junction resolvase Hjc	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
C [auth D]	d1gefd_	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	Hjc-like	Archaeal Holliday junction resolvase Hjc	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)
D [auth E]	d1gefe_	Alpha and beta proteins (a/b)	Restriction endonuclease-like	Restriction endonuclease-like	Hjc-like	Archaeal Holliday junction resolvase Hjc	(Pyrococcus furiosus ) [TaxId: 2261 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Hjc-like	8020397	4003382	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Restriction endonuclease-like	8032777	3000104	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Restriction endonuclease-like	8032777	3000104	SCOP2B (2022-06-29)
C [auth D]	SCOP2B Superfamily	Restriction endonuclease-like	8032777	3000104	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	Restriction endonuclease-like	8032777	3000104	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01870	e1gefA1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF01870	ECOD (1.6)
B	PF01870	e1gefB1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF01870	ECOD (1.6)
C [auth D]	PF01870	e1gefD1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF01870	ECOD (1.6)
D [auth E]	PF01870	e1gefE1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF01870	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1350.10	Alpha Beta	3-Layer(aba) Sandwich	Trna Endonuclease	Chain: A, domain 1	CATH (4.3.0)
B	3.40.1350.10	Alpha Beta	3-Layer(aba) Sandwich	Trna Endonuclease	Chain: A, domain 1	CATH (4.3.0)
C [auth D]	3.40.1350.10	Alpha Beta	3-Layer(aba) Sandwich	Trna Endonuclease	Chain: A, domain 1	CATH (4.3.0)
D [auth E]	3.40.1350.10	Alpha Beta	3-Layer(aba) Sandwich	Trna Endonuclease	Chain: A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth E]	PF01870	Archaeal holliday junction resolvase (hjc) (Hjc)	Archaeal holliday junction resolvase (hjc)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth E]	HOLLIDAY JUNCTION RESOLVASE	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity catalytic activity, acting on a nucleic acid hydrolase activity crossover junction DNA endonuclease activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity catalytic activity, acting on a nucleic acid hydrolase activity crossover junction DNA endonuclease activity DNA nuclease activity DNA endonuclease activity DNA endonuclease activity, producing 3'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair DNA recombination	protein-containing complex catalytic complex endodeoxyribonuclease complex Holliday junction resolvase complex intracellular protein-containing complex endonuclease complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth E]	IPR014428	Crossover junction endodeoxyribonuclease Hjc, archaeal	Family
A, B, C [auth D], D [auth E]	IPR011335	Restriction endonuclease type II-like	Homologous Superfamily
A, B, C [auth D], D [auth E]	IPR011856	tRNA endonuclease-like domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth E]	IPR002732	Holliday junction resolvase Hjc	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.