1GDT

CRYSTAL STRUCTURE OF A SITE-SPECIFIC RECOMBINASE, GAMMA-DELTA RESOLVASE COMPLEXED WITH A 34 BP CLEAVAGE SITE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1gdta1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Recombinase DNA-binding domain	gamma,delta resolvase (C-terminal domain)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
E [auth A]	d1gdta2	Alpha and beta proteins (a/b)	Resolvase-like	Resolvase-like	gamma,delta resolvase, catalytic domain	gamma,delta resolvase, catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth B]	d1gdtb1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Recombinase DNA-binding domain	gamma,delta resolvase (C-terminal domain)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F [auth B]	d1gdtb2	Alpha and beta proteins (a/b)	Resolvase-like	Resolvase-like	gamma,delta resolvase, catalytic domain	gamma,delta resolvase, catalytic domain	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2 Family	Recombinase DNA-binding domain-like	8003598	4000311	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Family	TnpR catalytic domain-like	8003595	4000296	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Homeodomain-like	8017624	3000001	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Resolvase-like	8003596	3000065	SCOP2 (2022-06-29)
F [auth B]	SCOP2B Superfamily	Resolvase-like	8003596	3000065	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Homeodomain-like	8017624	3000001	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	HTH_7	e1gdtA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_7	ECOD (1.6)
E [auth A]	Resolvase	e1gdtA2	A: a/b three-layered sandwiches	X: Resolvase-like (From Topology)	H: Resolvase-like (From Topology)	T: Resolvase-like	F: Resolvase	ECOD (1.6)
F [auth B]	HTH_7	e1gdtB3	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: HTH_7	ECOD (1.6)
F [auth B]	Resolvase	e1gdtB1	A: a/b three-layered sandwiches	X: Resolvase-like (From Topology)	H: Resolvase-like (From Topology)	T: Resolvase-like	F: Resolvase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	3.40.50.1390	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Resolvase, N-terminal catalytic domain	CATH (4.3.0)
E [auth A]	6.10.250.10	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
F [auth B]	3.40.50.1390	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Resolvase, N-terminal catalytic domain	CATH (4.3.0)
F [auth B]	6.10.250.10	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
F [auth B]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B]	PF00239	Resolvase, N terminal domain (Resolvase)	Resolvase, N terminal domain	The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see Pfam:PF02796.	Domain
E [auth A], F [auth B]	PF02796	Helix-turn-helix domain of resolvase (HTH_7)	Helix-turn-helix domain of resolvase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth D], D [auth F]	SITE I OF RES DNA	-	-	-
E [auth A], F [auth B]	PROTEIN (GAMMA DELTA RESOLVASE)	DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid DNA strand exchange activity catalytic activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process	-
A [auth C]	SITE I OF RES DNA	-	-	-
C [auth E]	SITE I OF RES DNA	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B]	IPR036162	Resolvase-like, N-terminal catalytic domain superfamily	Homologous Superfamily
E [auth A], F [auth B]	IPR006118	Recombinase, conserved site	Conserved Site
E [auth A], F [auth B]	IPR006119	Resolvase, N-terminal catalytic domain	Domain
E [auth A], F [auth B]	IPR006120	Resolvase, HTH domain	Domain
E [auth A], F [auth B]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.