1G4W

CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth R]	d1g4wr1	All alpha proteins	Four-helical up-and-down bundle	Bacterial GAP domain	Bacterial GAP domain	SptP tyrosine phosphatase	(Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ],	SCOPe (2.08)
A [auth R]	d1g4wr2	Alpha and beta proteins (a/b)	(Phosphotyrosine protein) phosphatases II	(Phosphotyrosine protein) phosphatases II	Higher-molecular-weight phosphotyrosine protein phosphatases	SptP tyrosine phosphatase, catalytic domain	(Salmonella enterica subsp. enterica serovar Typhimurium ) [TaxId: 90371 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth R]	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8044349	3000304	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth R]	PF03545	e1g4wR3	A: alpha bundles	X: Four-helical up-and-down bundle	H: Bacterial GAP domain (From Topology)	T: Bacterial GAP domain	F: PF03545	ECOD (1.6)
A [auth R]	PF00102	e1g4wR2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: PF00102	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth R]	1.20.120.260	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Virulence factor YopE uncharacterised domain	CATH (4.3.0)
A [auth R]	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth R]	PF00102	Protein-tyrosine phosphatase (Y_phosphatase)	Protein-tyrosine phosphatase	-	Domain
A [auth R]	PF03545	Yersinia virulence determinant (YopE) (YopE)	Yersinia virulence determinant (YopE)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth R]	PROTEIN TYROSINE PHOSPHATASE SPTP	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity	dephosphorylation cellular metabolic process phosphate-containing compound metabolic process metabolic process cellular process phosphorus metabolic process	extracellular region extracellular space cellular anatomical entity host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth R]	IPR003546	Type III secreted modular tyrosine phosphatase, SptP/YopH	Family
A [auth R]	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A [auth R]	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A [auth R]	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A [auth R]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
A [auth R]	IPR014773	Virulence factor YopE, GAP domain	Domain
A [auth R]	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A [auth R]	IPR015203	Secreted effector protein SptP, N-terminal domain	Domain
A [auth R]	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A [auth R]	IPR044899	Secreted effector protein SptP, N-terminal domain superfamily	Homologous Superfamily
A [auth R]	IPR037168	Virulence factor YopE, GAP domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.