1G3N

STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1g3nb_	Alpha and beta proteins (a+b)	beta-hairpin-alpha-hairpin repeat	Ankyrin repeat	Ankyrin repeat	p18ink4C(ink6)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth F]	d1g3nf_	Alpha and beta proteins (a+b)	beta-hairpin-alpha-hairpin repeat	Ankyrin repeat	Ankyrin repeat	p18ink4C(ink6)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1g3nc1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Viral cyclin	(Human gammaherpesvirus 8 ) [TaxId: 37296 ],	SCOPe (2.08)
F [auth G]	d1g3ng1	All alpha proteins	Cyclin-like	Cyclin-like	Cyclin	Viral cyclin	(Human gammaherpesvirus 8 ) [TaxId: 37296 ],	SCOPe (2.08)
A	d1g3na_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Cyclin-dependent PK, CDK6	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth E]	d1g3ne_	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	Protein kinases, catalytic subunit	Cyclin-dependent PK, CDK6	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Ankyrin repeat	8057704	3000154	SCOP2B (2022-06-29)
E [auth F]	SCOP2B Superfamily	Ankyrin repeat	8057704	3000154	SCOP2B (2022-06-29)
C	SCOP2 Family	Cyclin	8025542	4001102	SCOP2 (2022-06-29)
C	SCOP2 Family	Cyclin	8025545	4001102	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Cyclin-like	8037921	3000768	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Cyclin-like	8037924	3000768	SCOP2 (2022-06-29)
F [auth G]	SCOP2B Superfamily	Cyclin-like	8037921	3000768	SCOP2B (2022-06-29)
F [auth G]	SCOP2B Superfamily	Cyclin-like	8037924	3000768	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036604	3000066	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036604	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ank_2	e1g3nB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)
E [auth F]	Ank_2	e1g3nF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: Ank_2	ECOD (1.6)
C	Cyclin_N	e1g3nC1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: Cyclin_N	ECOD (1.6)
C	K-cyclin_vir_C	e1g3nC2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: K-cyclin_vir_C	ECOD (1.6)
F [auth G]	Cyclin_N	e1g3nG1	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: Cyclin_N	ECOD (1.6)
F [auth G]	K-cyclin_vir_C	e1g3nG2	A: alpha arrays	X: HTH	H: HTH	T: Cyclin-like	F: K-cyclin_vir_C	ECOD (1.6)
A	Pkinase_Tyr	e1g3nA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D [auth E]	Pkinase_Tyr	e1g3nE1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)
E [auth F]	1.25.40.20	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Ankyrin repeat-containing domain	CATH (4.3.0)
C	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
F [auth G]	1.10.472.10	Mainly Alpha	Orthogonal Bundle	Cyclin A	domain 1	CATH (4.3.0)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D [auth E]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D [auth E]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, E [auth F]	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat
C, F [auth G]	PF00134	Cyclin, N-terminal domain (Cyclin_N)	Cyclin, N-terminal domain	Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins [4]. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.	Domain
C, F [auth G]	PF09080	K cyclin, C terminal (K-cyclin_vir_C)	K cyclin, C terminal	Members of this family adopt a secondary structure consisting of a five alpha-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity ...	Members of this family adopt a secondary structure consisting of a five alpha-helix cyclin fold. Interaction with cyclin dependent kinases (CDKs) at a PSTAIRE sequence motif within the catalytic cleft of CDK results in the regulation of CDK activity [1].	Domain
A, D [auth E]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, E [auth F]	CYCLIN-DEPENDENT KINASE 6 INHIBITOR	protein binding binding kinase binding enzyme binding protein kinase binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity protein binding binding kinase binding enzyme binding protein kinase binding enzyme regulator activity enzyme inhibitor activity protein kinase regulator activity protein kinase inhibitor activity molecular function inhibitor activity cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function regulator activity cyclin-dependent protein serine/threonine kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity	cellular process cell cycle regulation of biological process regulation of cellular process phosphorylation cellular metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process negative regulation of phosphate metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process cellular process cell cycle regulation of biological process regulation of cellular process phosphorylation cellular metabolic process negative regulation of metabolic process biological regulation negative regulation of biological process negative regulation of phosphate metabolic process regulation of cellular metabolic process negative regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of phosphorus metabolic process negative regulation of cellular process regulation of phosphorus metabolic process metabolic process regulation of phosphorylation negative regulation of phosphorylation phosphorus metabolic process regulation of metabolic process negative regulation of cell population proliferation regulation of stem cell proliferation cell population proliferation negative regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation developmental process multicellular organismal process cellular developmental process nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis oligodendrocyte differentiation glial cell differentiation cell differentiation anatomical structure development system development regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of primary metabolic process organic substance metabolic process regulation of cyclin-dependent protein serine/threonine kinase activity protein metabolic process protein modification process regulation of cell cycle organonitrogen compound metabolic process protein phosphorylation regulation of protein metabolic process primary metabolic process regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity macromolecule metabolic process regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
C, F [auth G]	V-CYCLIN	-	-	-
A, D [auth E]	CYCLIN-DEPENDENT KINASE 6	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity cyclin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups protein binding cyclin binding protein serine kinase activity FBXO family protein binding	response to organic substance response to stimulus response to chemical regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion response to organic substance response to stimulus response to chemical regulation of biological process regulation of cellular process regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion biological regulation positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion cellular process positive regulation of cellular process cell division cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process negative regulation of cellular process negative regulation of biological process negative regulation of cell cycle cell cycle regulation of cell cycle developmental process multicellular organismal process head development lateral ventricle development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development ventricular system development anatomical structure development telencephalon development system development cellular developmental process regulation of developmental process homeostatic process cell development regulation of cell differentiation regulation of cell development cell differentiation regulation of immune system process regulation of multicellular organismal process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process regulation of hemopoiesis homeostasis of number of cells astrocyte differentiation glial cell development neurogenesis astrocyte development gliogenesis glial cell differentiation cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell differentiation in thymus T cell activation T cell differentiation leukocyte differentiation protein phosphorylation organonitrogen compound metabolic process phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process mitotic cell cycle process cell cycle phase transition G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process generation of neurons cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle epithelial cell differentiation pancreas development columnar/cuboidal epithelial cell development endocrine pancreas development type B pancreatic cell differentiation epithelium development glandular epithelial cell development endocrine system development type B pancreatic cell development tissue development glandular epithelial cell differentiation epithelial cell development enteroendocrine cell differentiation columnar/cuboidal epithelial cell differentiation negative regulation of developmental process negative regulation of cell differentiation negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process negative regulation of biosynthetic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation myeloid leukocyte differentiation regulation of leukocyte differentiation monocyte differentiation negative regulation of hemopoiesis negative regulation of monocyte differentiation regulation of monocyte differentiation negative regulation of leukocyte differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of immune system process negative regulation of multicellular organismal process cellular response to stimulus cell surface receptor signaling pathway signaling cell communication Notch signaling pathway signal transduction regulation of hematopoietic stem cell differentiation stem cell differentiation regulation of stem cell differentiation hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation regulation of osteoblast differentiation negative regulation of osteoblast differentiation osteoblast differentiation ossification fibroblast proliferation positive regulation of cell population proliferation regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of cellular senescence cellular senescence negative regulation of cellular senescence cellular response to stress response to stress cell dedifferentiation dedifferentiation dentate gyrus development pallium development hippocampus development limbic system development biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus regulation of cell motility regulation of locomotion cell motility locomotion	protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex cyclin D2-CDK6 complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol ruffle cell projection protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex cyclin D2-CDK6 complex catalytic complex serine/threonine protein kinase complex cyclin-dependent protein kinase holoenzyme complex transferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol ruffle cell projection cell leading edge plasma membrane bounded cell projection intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, E [auth F]	IPR002110	Ankyrin repeat	Repeat
B, E [auth F]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
C, F [auth G]	IPR048258	Cyclins, cyclin-box	Conserved Site
C, F [auth G]	IPR017285	Cyclin, herpesvirus	Family
C, F [auth G]	IPR036915	Cyclin-like superfamily	Homologous Superfamily
C, F [auth G]	IPR015164	K cyclin, C-terminal	Domain
C, F [auth G]	IPR039361	Cyclin	Family
C, F [auth G]	IPR013763	Cyclin-like domain	Domain
C, F [auth G]	IPR006671	Cyclin, N-terminal	Domain
A, D [auth E]	IPR000719	Protein kinase domain	Domain
A, D [auth E]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, D [auth E]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, D [auth E]	IPR028788	Cyclin-dependent kinase 6	Family
A, D [auth E]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, E [auth F]	Pharos: P42773	multiple endocrine neoplasia type 1 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma astrocytic tumor breast carcinoma cerebrovascular disorder glioma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma psoriasis atrial fibrillation breast fibroadenoma ductal breast carcinoma in situ multiple endocrine neoplasia type 1 pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia plasma cell myeloma astrocytic tumor breast carcinoma cerebrovascular disorder glioma malignant ependymoma medulloblastoma osteosarcoma pilocytic astrocytoma psoriasis atrial fibrillation breast fibroadenoma ductal breast carcinoma in situ hepatocellular carcinoma malignant glioma ovarian cancer pituitary cancer renal cell carcinoma breast cancer cancer glioblastoma invasive ductal breast carcinoma Malignant neoplasm of breast oligodendroglioma
A, D [auth E]	Pharos: Q00534	rheumatoid arthritis medulloblastoma microcephaly 12, primary, autosomal recessive glioblastoma acute myeloid leukemia microcephaly giant cell glioblastoma anemia childhood medulloblastoma Chromosome Aberrations atrial fibrillation medullomyoblastoma with myogenic differentiation cancer adult medulloblastoma malignant mesothelioma rheumatoid arthritis medulloblastoma microcephaly 12, primary, autosomal recessive glioblastoma acute myeloid leukemia microcephaly giant cell glioblastoma anemia childhood medulloblastoma Chromosome Aberrations atrial fibrillation medullomyoblastoma with myogenic differentiation cancer adult medulloblastoma malignant mesothelioma melanotic medulloblastoma childhood acute lymphoblastic leukemia ovarian cancer cholangiocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia desmoplastic/nodular medulloblastoma primitive neuroectodermal tumor sarcoidosis lung cancer autosomal recessive primary microcephaly malignant ependymoma malignant pancreatic neoplasm breast disease cerebrovascular disorder pancreatic ductal adenocarcinoma pilocytic astrocytoma psoriasis invasive ductal breast carcinoma transitional cell carcinoma adrenal cortex adenoma liposarcoma lung carcinoma malignant glioma brainstem cancer metastatic melanoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma cystic fibrosis eye disease large cell medulloblastoma tuberculosis lung adenocarcinoma atypical teratoid rhabdoid tumor lymphoma breast cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.