Annotations: 1G1Q

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d1g1qd1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	P-selectin, C-lectin domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1g1qd2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	E-selectin, EGF-domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1g1qd3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1g1qa1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	P-selectin, C-lectin domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1g1qa2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	E-selectin, EGF-domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1g1qa3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1g1qb1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	P-selectin, C-lectin domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1g1qb2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	E-selectin, EGF-domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1g1qb3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1g1qc1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	C-type lectin domain	P-selectin, C-lectin domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1g1qc2	Small proteins	Knottins (small inhibitors, toxins, lectins)	EGF/Laminin	EGF-type module	E-selectin, EGF-domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1g1qc3	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	C-type lectin-like	8035750	3001261	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EGF/Laminin-like	8038328	3000412	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	EGF/Laminin-like	8038328	3000412	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	C-type lectin-like	8035750	3001261	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EGF/Laminin-like	8038328	3000412	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	C-type lectin-like	8035750	3001261	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EGF/Laminin-like	8038328	3000412	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	C-type lectin-like	8035750	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Lectin_C	e1g1qD1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
D	hEGF_2	e1g1qD2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_2	ECOD (1.6)
A	Lectin_C	e1g1qA1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
A	hEGF_2	e1g1qA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_2	ECOD (1.6)
B	Lectin_C	e1g1qB1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
B	hEGF_2	e1g1qB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_2	ECOD (1.6)
C	Lectin_C	e1g1qC1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Lectin_C	ECOD (1.6)
C	hEGF_2	e1g1qC2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: hEGF_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
D	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
A	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
B	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
B	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)
C	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)
C	2.10.25.10	Mainly Beta	Ribbon	Laminin	Laminin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00059	Lectin C-type domain (Lectin_C)	Lectin C-type domain	This family includes both long and short form C-type	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	P-SELECTIN	sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding cation binding calcium ion binding metal ion binding glycosphingolipid binding sphingolipid binding lipid binding sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding cation binding calcium ion binding metal ion binding glycosphingolipid binding sphingolipid binding lipid binding glycolipid binding lipopolysaccharide binding oligosaccharide binding carbohydrate binding fucose binding monosaccharide binding calcium-dependent protein binding protein binding heparin binding glycosaminoglycan binding sulfur compound binding	leukocyte tethering or rolling leukocyte cell-cell adhesion leukocyte migration cell adhesion cell-cell adhesion immune system process leukocyte adhesion to vascular endothelial cell cellular extravasation cell migration cellular process cell motility regulation of biological process regulation of cellular process regulation of cellular component organization leukocyte tethering or rolling leukocyte cell-cell adhesion leukocyte migration cell adhesion cell-cell adhesion immune system process leukocyte adhesion to vascular endothelial cell cellular extravasation cell migration cellular process cell motility regulation of biological process regulation of cellular process regulation of cellular component organization protein-containing complex organization biological regulation regulation of cellular component biogenesis cellular component biogenesis cellular component organization regulation of protein-containing complex assembly cellular component assembly regulation of integrin activation protein-containing complex assembly cellular component organization or biogenesis integrin activation heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell-cell adhesion via plasma-membrane adhesion molecules cellular response to stimulus positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling response to organic substance response to chemical response to cytokine positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration regulation of immune system process positive regulation of immune system process locomotion positive regulation of leukocyte cell-cell adhesion regulation of leukocyte adhesion to vascular endothelial cell positive regulation of cell-cell adhesion positive regulation of leukocyte tethering or rolling regulation of cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of leukocyte adhesion to vascular endothelial cell regulation of leukocyte tethering or rolling regulation of leukocyte cell-cell adhesion regulation of cellular extravasation biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus inflammatory response multicellular organismal process regulation of body fluid levels regulation of cell activation positive regulation of platelet activation positive regulation of cell activation coagulation regulation of multicellular organismal process regulation of biological quality response to wounding wound healing cell activation hemostasis blood coagulation regulation of platelet activation positive regulation of multicellular organismal process platelet activation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane platelet dense granule membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane platelet dense granule membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle platelet dense granule secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane platelet alpha granule membrane platelet alpha granule extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016187	C-type lectin fold	Homologous Superfamily
A, B, C, D	IPR001304	C-type lectin-like	Domain
A, B, C, D	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A, B, C, D	IPR000436	Sushi/SCR/CCP domain	Domain
A, B, C, D	IPR000742	EGF-like domain	Domain
A, B, C, D	IPR002396	Selectin superfamily	Family
A, B, C, D	IPR035976	Sushi/SCR/CCP superfamily	Homologous Superfamily
A, B, C, D	IPR033991	Selectin, C-type lectin-like domain	Domain
A, B, C, D	IPR018378	C-type lectin, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P16109	hypertensive disorder melancholia Neurobehavioral Manifestations IgE responsiveness, atopic allergic disease pleurisy thrombotic disease coronary artery disease endogenous depression large cell medulloblastoma lung carcinoma osteosarcoma acne pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer hypertensive disorder melancholia Neurobehavioral Manifestations IgE responsiveness, atopic allergic disease pleurisy thrombotic disease coronary artery disease endogenous depression large cell medulloblastoma lung carcinoma osteosarcoma acne pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer peripheral neuropathy cutaneous lupus erythematosus depressive disorder ulcerative colitis exocrine pancreatic carcinoma invasive ductal breast carcinoma lung adenocarcinoma malignant pancreatic neoplasm myocardial ischemia neurotic disorder pancreatic intraductal papillary-mucinous carcinoma peripheral arterial disease cerebrovascular disorder inflammatory bowel disease lung cancer MALT lymphoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm atherosclerosis peripheral nervous system disease thrombocytopenia interstitial cystitis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.