1FM7

CHALCONE ISOMERASE COMPLEXED WITH 5-DEOXYFLAVANONE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fm7a_	Alpha and beta proteins (a+b)	Chalcone isomerase	Chalcone isomerase	Chalcone isomerase	Chalcone isomerase	(Medicago sativa ) [TaxId: 3879 ],	SCOPe (2.08)
B	d1fm7b_	Alpha and beta proteins (a+b)	Chalcone isomerase	Chalcone isomerase	Chalcone isomerase	Chalcone isomerase	(Medicago sativa ) [TaxId: 3879 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cytochrome P460/chalcone isomerase-like	8034958	3000788	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cytochrome P460/chalcone isomerase-like	8034958	3000788	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chalcone	e1fm7A1	A: a+b two layers	X: Chalcone isomerase (From Topology)	H: Chalcone isomerase (From Topology)	T: Chalcone isomerase	F: Chalcone	ECOD (1.6)
B	Chalcone	e1fm7B1	A: a+b two layers	X: Chalcone isomerase (From Topology)	H: Chalcone isomerase (From Topology)	T: Chalcone isomerase	F: Chalcone	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.890.20	Mainly Alpha	Orthogonal Bundle	10k-s Protein, Hypothetical Protein A	Chain A	CATH (4.3.0)
A	3.50.70.10	Alpha Beta	3-Layer(bba) Sandwich	Chalcone isomerase		CATH (4.3.0)
B	1.10.890.20	Mainly Alpha	Orthogonal Bundle	10k-s Protein, Hypothetical Protein A	Chain A	CATH (4.3.0)
B	3.50.70.10	Alpha Beta	3-Layer(bba) Sandwich	Chalcone isomerase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02431	Chalcone-flavanone isomerase (Chalcone)	Chalcone-flavanone isomerase	Chalcone-flavanone isomerase is a plant enzyme responsible for the isomerisation of chalcone to naringenin, 4',5,7-trihydroxyflavanone, a key step in the biosynthesis of flavonoids.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CHALCONE-FLAVONONE ISOMERASE 1	intramolecular lyase activity isomerase activity chalcone isomerase activity catalytic activity	flavonoid metabolic process organic substance metabolic process flavonoid biosynthetic process biosynthetic process organic substance biosynthetic process metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016087	Chalcone isomerase	Domain
A, B	IPR016088	Chalcone isomerase, 3-layer sandwich	Homologous Superfamily
A, B	IPR044164	Chalcone--flavonone isomerase	Family
A, B	IPR016089	Chalcone isomerase, orthogonal bundle domain superfamily	Homologous Superfamily
A, B	IPR036298	Chalcone isomerase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.