Annotations: 1FG9

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1fg9b_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-gamma	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1fg9a_	All alpha proteins	4-helical cytokines	4-helical cytokines	Interferons/interleukin-10 (IL-10)	Interferon-gamma	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1fg9d1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Interferon-gamma receptor alpha chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1fg9e1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Interferon-gamma receptor alpha chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1fg9c1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	Fibronectin type III	Interferon-gamma receptor alpha chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	4-helical cytokines	8039129	3001717	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	4-helical cytokines	8039129	3001717	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibronectin type III	8055143	3002063	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibronectin type III	8055531	3002063	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Fibronectin type III	8055531	3002063	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Fibronectin type III	8055143	3002063	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8055143	3002063	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Fibronectin type III	8055531	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	IFN-gamma	e1fg9B1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IFN-gamma	ECOD (1.6)
A	IFN-gamma	e1fg9A1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IFN-gamma	ECOD (1.6)
D	IFNGR1_1st	e1fg9D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IFNGR1_1st	ECOD (1.6)
D	Tissue_fac	e1fg9D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Tissue_fac	ECOD (1.6)
E	IFNGR1_1st	e1fg9E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IFNGR1_1st	ECOD (1.6)
E	Tissue_fac	e1fg9E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Tissue_fac	ECOD (1.6)
C	IFNGR1_1st	e1fg9C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IFNGR1_1st	ECOD (1.6)
C	Tissue_fac	e1fg9C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Tissue_fac	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
A	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B	IFNG (Interferon gamma)	IFNG	Homo sapiens (human)	IFNG*01	R-LIKE-DOMAIN IFNG (Pr21-161)	RPI	IFNG	IMGT (202415-0)
C, D, E	IFNGR1 (Interferon gamma receptor alpha)	2F-DOMAIN	Homo sapiens (human)	IFNGR1*01	F-LIKE-DOMAIN F-DOMAIN	RPI	2F-DOMAIN	IMGT (202415-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00714	Interferon gamma (IFN-gamma)	Interferon gamma	-	Domain
C, D, E	PF07140	Interferon gamma receptor (IFNGR1), D2 domain (IFNGR1_D2)	Interferon gamma receptor (IFNGR1), D2 domain	This entry consists of mammal and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signalling pathways relevant to immune function. Human interferon-gamm ...	This entry consists of mammal and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signalling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta) [1]. The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection [2]. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac Pfam:PF01108 (which represents the D1 domain), and this domain represents the D2 domain [1,3], both of which adopt an Ig-like fold. This domain is mediates receptor-receptor contacts [3].	Domain
C, D, E	PF01108	Tissue factor (Tissue_fac)	Tissue factor	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	INTERFERON GAMMA	type II interferon receptor binding protein binding binding signaling receptor binding cytokine receptor binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process regulation of cellular process fat-soluble vitamin metabolic process regulation of lipid metabolic process vitamin biosynthetic process vitamin D biosynthetic process regulation of primary metabolic process positive regulation of vitamin metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process organic substance biosynthetic process small molecule metabolic process regulation of vitamin metabolic process positive regulation of vitamin D biosynthetic process cellular metabolic process regulation of cellular metabolic process primary metabolic process organic cyclic compound metabolic process positive regulation of steroid biosynthetic process organic cyclic compound biosynthetic process regulation of steroid biosynthetic process cellular biosynthetic process steroid metabolic process organic hydroxy compound metabolic process lipid biosynthetic process positive regulation of cellular metabolic process organic substance metabolic process steroid biosynthetic process positive regulation of cellular process small molecule biosynthetic process regulation of steroid metabolic process vitamin D metabolic process regulation of vitamin D biosynthetic process vitamin metabolic process regulation of cellular biosynthetic process positive regulation of lipid biosynthetic process organic hydroxy compound biosynthetic process fat-soluble vitamin biosynthetic process positive regulation of steroid metabolic process cellular process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of cellular biosynthetic process lipid metabolic process response to stimulus immune response immune system process adaptive immune response regulation of defense response regulation of response to external stimulus defense response response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response positive regulation of macromolecule biosynthetic process positive regulation of macromolecule metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis apoptotic process cell death programmed cell death cellular response to stimulus cell surface receptor signaling pathway signaling extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction import into cell transport vesicle-mediated transport positive regulation of endocytosis phagocytosis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport endocytosis establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization import into nucleus establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of protein localization to organelle regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of establishment of protein localization regulation of protein transport protein transport protein localization to organelle multicellular organismal process interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of multicellular organismal process positive regulation of cytokine production regulation of signaling positive regulation of signaling receptor activity regulation of signaling receptor activity regulation of signal transduction positive regulation of molecular function regulation of molecular function regulation of cell communication response to organic substance biological process involved in interspecies interaction between organisms response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway innate immune response cellular response to cytokine stimulus cellular response to organic substance response to external biotic stimulus response to other organism type II interferon-mediated signaling pathway defense response to symbiont cellular response to chemical stimulus response to chemical defense response to other organism macrophage activation involved in immune response cell activation cell activation involved in immune response myeloid cell activation involved in immune response myeloid leukocyte activation leukocyte activation immune effector process macrophage activation leukocyte activation involved in immune response regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell amide transport signal release secretion regulation of peptide transport cell-cell signaling export from cell peptide transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion regulation of chemokine production chemokine production positive regulation of chemokine production cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development multicellular organism development neurogenesis astrocyte development gliogenesis cell differentiation anatomical structure development system development developmental process nervous system development central nervous system development glial cell differentiation glial cell activation neuroinflammatory response regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of fructose 1,6-bisphosphate 1-phosphatase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity phosphorus metabolic process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation dephosphorylation regulation of carbohydrate phosphatase activity positive regulation of catalytic activity positive regulation of hydrolase activity regulation of hydrolase activity regulation of phosphorus metabolic process positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation regulation of cell development alpha-beta T cell differentiation involved in immune response positive regulation of immune response positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response T cell activation alpha-beta T cell activation regulation of immune system process positive regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of cell development regulation of leukocyte cell-cell adhesion positive regulation of alpha-beta T cell differentiation regulation of developmental process positive regulation of leukocyte cell-cell adhesion CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response CD4-positive, alpha-beta T cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation positive regulation of immune effector process regulation of cell-cell adhesion hemopoiesis positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of cell adhesion regulation of CD4-positive, alpha-beta T cell activation regulatory T cell differentiation regulation of lymphocyte activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of developmental process positive regulation of cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of regulatory T cell differentiation positive regulation of alpha-beta T cell activation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of immune response leukocyte differentiation regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation lymphocyte activation leukocyte cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion cell-cell adhesion alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation lymphocyte activation involved in immune response regulation of lymphocyte differentiation regulation of multicellular organismal development positive regulation of cell adhesion regulation of regulatory T cell differentiation regulation of T cell activation T cell differentiation involved in immune response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation positive regulation of phosphorylation regulation of transferase activity positive regulation of protein serine/threonine kinase activity protein modification process positive regulation of protein phosphorylation protein phosphorylation phosphorylation regulation of protein metabolic process positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation positive regulation of nervous system development regulation of neurogenesis regulation of nervous system development positive regulation of neurogenesis negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process interleukin-17 production negative regulation of interleukin-17 production negative regulation of metabolic process negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression regulation of interleukin-17 production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription negative regulation of RNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process catabolic process positive regulation of membrane protein ectodomain proteolysis macromolecule catabolic process cellular catabolic process regulation of proteolysis proteolysis membrane protein proteolysis membrane protein ectodomain proteolysis organonitrogen compound catabolic process regulation of membrane protein ectodomain proteolysis regulation of catabolic process protein catabolic process positive regulation of protein catabolic process positive regulation of catabolic process positive regulation of proteolysis regulation of cellular catabolic process positive regulation of cellular catabolic process organic substance catabolic process regulation of protein catabolic process defense response to virus response to virus positive regulation of autophagy autophagy regulation of autophagy process utilizing autophagic mechanism leukocyte activation involved in inflammatory response microglial cell activation positive regulation of cation transmembrane transport iron import into cell positive regulation of iron ion transmembrane transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of monoatomic ion transport import across plasma membrane iron ion transport iron ion transmembrane transport inorganic ion transmembrane transport positive regulation of iron ion import across plasma membrane inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis homeostatic process monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport intracellular iron ion homeostasis regulation of iron ion transmembrane transport intracellular monoatomic cation homeostasis positive regulation of transmembrane transport monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of iron ion import across plasma membrane iron ion import across plasma membrane positive regulation of iron ion transport regulation of iron ion transport inorganic cation import across plasma membrane cellular homeostasis inorganic ion import across plasma membrane transition metal ion transport regulation of monoatomic cation transmembrane transport positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor (ligand) superfamily member 11 production positive regulation of tumor necrosis factor (ligand) superfamily member 11 production tumor necrosis factor superfamily cytokine production regulation of tumor necrosis factor (ligand) superfamily member 11 production regulation of tumor necrosis factor superfamily cytokine production pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process organophosphate catabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process regulation of nucleotide metabolic process purine ribonucleotide catabolic process nucleoside phosphate metabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process positive regulation of carbohydrate metabolic process monocarboxylic acid metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process ribonucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process pyridine-containing compound metabolic process pyridine nucleotide metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process positive regulation of nucleotide metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process ADP catabolic process carboxylic acid metabolic process generation of precursor metabolites and energy regulation of glycolytic process positive regulation of purine nucleotide metabolic process organophosphate metabolic process humoral immune response interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production response to type III interferon type III interferon-mediated signaling pathway cellular response to type III interferon negative regulation of cell population proliferation cell population proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation epithelial cell differentiation regulation of epithelial cell differentiation negative regulation of cell differentiation epithelium development negative regulation of epithelial cell differentiation negative regulation of developmental process tissue development regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production regulation of oxidoreductase activity positive regulation of oxidoreductase activity regulation of monooxygenase activity positive regulation of monooxygenase activity positive regulation of calcidiol 1-monooxygenase activity regulation of calcidiol 1-monooxygenase activity regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process positive regulation of cell population proliferation regulation of amide metabolic process amyloid precursor protein catabolic process regulation of amyloid-beta formation positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process amyloid precursor protein metabolic process amyloid-beta formation positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process regulation of fructose 1,6-bisphosphate metabolic process positive regulation of fructose 1,6-bisphosphate metabolic process fructose 1,6-bisphosphate metabolic process positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process myeloid leukocyte differentiation macrophage differentiation myeloid cell differentiation positive regulation of NMDA glutamate receptor activity regulation of transmembrane transporter activity regulation of transporter activity regulation of NMDA receptor activity regulation of monoatomic ion transmembrane transporter activity positive regulation of transporter activity regulation of neurotransmitter receptor activity positive regulation of ion transmembrane transporter activity peptidyl-amino acid modification tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via STAT peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT positive regulation of interleukin-23 production interleukin-23 production regulation of interleukin-23 production exosomal secretion establishment of organelle localization positive regulation of secretion by cell positive regulation of exosomal secretion positive regulation of exocytosis positive regulation of secretion organelle localization vesicle localization regulation of exosomal secretion establishment of vesicle localization extracellular exosome biogenesis exocytosis extracellular vesicle biogenesis regulation of exocytosis positive regulation of killing of cells of another organism regulation of killing of cells of another organism disruption of cell in another organism regulation of cell killing positive regulation of cell killing disruption of anatomical structure in another organism modulation of process of another organism killing of cells of another organism cell killing regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process negative regulation of catalytic activity negative regulation of kinase activity negative regulation of transferase activity negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of tau-protein kinase activity regulation of tau-protein kinase activity negative regulation of molecular function negative regulation of protein kinase activity negative regulation of phosphorus metabolic process negative regulation of phosphorylation negative regulation of amyloid-beta clearance amyloid-beta clearance regulation of amyloid-beta clearance regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production tumor necrosis factor production cellular respiration energy derivation by oxidation of organic compounds regulation of cellular respiration positive regulation of cellular respiration regulation of core promoter binding regulation of DNA binding regulation of binding regulation of transcription regulatory region DNA binding positive regulation of core promoter binding positive regulation of binding positive regulation of DNA binding positive regulation of transcription regulatory region DNA binding cellular response to virus regulation of peptidyl-serine phosphorylation regulation of receptor signaling pathway via JAK-STAT positive regulation of peptidyl-serine phosphorylation of STAT protein serine phosphorylation of STAT protein regulation of receptor signaling pathway via STAT regulation of peptidyl-serine phosphorylation of STAT protein peptidyl-serine modification peptidyl-serine phosphorylation positive regulation of peptidyl-serine phosphorylation positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of osteoclast differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of myeloid cell differentiation positive regulation of protein deacetylation macromolecule deacylation protein deacetylation regulation of protein deacetylation protein deacylation	extracellular region extracellular space cellular anatomical entity
C, D, E	INTERFERON-GAMMA RECEPTOR ALPHA CHAIN	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity protein binding binding cytokine binding type II interferon receptor activity interferon receptor activity	cellular response to stimulus response to organic substance regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus signaling response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus cell communication interferon-mediated signaling pathway response to stress innate immune response cellular response to stimulus response to organic substance regulation of cellular process biological process involved in interspecies interaction between organisms response to stimulus signaling response to type II interferon response to cytokine cytokine-mediated signaling pathway cellular response to type II interferon response to biotic stimulus cell communication interferon-mediated signaling pathway response to stress innate immune response cellular response to cytokine stimulus cellular response to organic substance signal transduction response to external biotic stimulus regulation of biological process cell surface receptor signaling pathway immune response response to other organism defense response type II interferon-mediated signaling pathway biological regulation defense response to symbiont response to external stimulus cellular response to chemical stimulus response to chemical immune system process defense response to other organism cellular process regulation of amide metabolic process amyloid precursor protein catabolic process positive regulation of protein metabolic process regulation of amyloid-beta formation positive regulation of biological process positive regulation of amyloid-beta formation regulation of amyloid precursor protein catabolic process regulation of primary metabolic process positive regulation of metabolic process organic substance metabolic process amyloid-beta metabolic process positive regulation of macromolecule metabolic process amide metabolic process protein metabolic process amyloid precursor protein metabolic process amyloid-beta formation organonitrogen compound metabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of amide metabolic process metabolic process macromolecule metabolic process positive regulation of amyloid precursor protein catabolic process regulation of metabolic process multicellular organismal process cellular developmental process astrocyte differentiation cell development astrocyte activation glial cell development multicellular organism development neurogenesis astrocyte development gliogenesis cell differentiation anatomical structure development system development developmental process cell activation nervous system development central nervous system development glial cell differentiation glial cell activation inflammatory response neuroinflammatory response cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process response to virus response to type III interferon type III interferon-mediated signaling pathway cellular response to type III interferon negative regulation of amyloid-beta clearance negative regulation of biological process regulation of multicellular organismal process amyloid-beta clearance regulation of amyloid-beta clearance negative regulation of multicellular organismal process regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production cytokine production regulation of cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production positive regulation of multicellular organismal process positive regulation of cytokine production myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation cellular response to virus	membrane cellular anatomical entity cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002069	Interferon gamma	Family
A, B	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
C, D, E	IPR008355	Interferon gamma receptor alpha subunit	Family
C, D, E	IPR003961	Fibronectin type III	Domain
C, D, E	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C, D, E	IPR021126	Interferon gamma receptor, D2 domain, poxvirus/mammal	Domain
C, D, E	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P01579	rheumatoid arthritis aplastic anemia pneumonia melanoma peritonitis congestive heart failure autoimmune disease glomerulonephritis leishmaniasis Stevens-Johnson syndrome adult T-cell leukemia/lymphoma oral submucous fibrosis allergic disease HIV infectious disease tuberous sclerosis rheumatoid arthritis aplastic anemia pneumonia melanoma peritonitis congestive heart failure autoimmune disease glomerulonephritis leishmaniasis Stevens-Johnson syndrome adult T-cell leukemia/lymphoma oral submucous fibrosis allergic disease HIV infectious disease tuberous sclerosis Crohn disease autoimmune hepatitis acute promyelocytic leukemia adrenoleukodystrophy hepatitis C virus infection trichuriasis Arthritis, Experimental hypotensive disorder mucocutaneous leishmaniasis atherosclerosis salmonella infections, animal bacterial arthritis Legionnaires' disease cutaneous leishmaniasis spindle cell sarcoma hepatitis breast carcinoma allergic contact dermatitis malignant colon neoplasm tuberculosis tuberous sclerosis 2 type III hypersensitivity disease respiratory syncytial virus infectious disease idiopathic aplastic anemia multiple sclerosis sarcoma kidney failure neural tube defect brain disease hepatitis B virus infection pleural disease bronchiolitis obliterans with obstructive pulmonary disease malignant mesothelioma proteinuria manganese poisoning visceral leishmaniasis colitis inflammatory bowel disease graft versus host disease breast cancer appendicitis Hyper-IgE recurrent infection syndrome 1 cardiac arrest chlamydia infectious disease inborn carbohydrate metabolic disorder colonic neoplasm congenital anemia exocrine pancreatic carcinoma iniencephaly COVID-19 kidney disease Crohn's colitis bipolar disorder lung benign neoplasm adrenomyeloneuropathy neurenteric cyst tethered spinal cord syndrome diastematomyelia alopecia areata pneumonitis arteriosclerosis disorder chronic graft versus host disease X-linked lymphoproliferative disease due to SH2D1A deficiency epithelioid sarcoma asthma combined immunodeficiency due to DOCK8 deficiency mycobacterium tuberculosis, susceptibility to atopic eczema interstitial cystitis craniorachischisis benign colon neoplasm skin disease cutaneous lupus erythematosus acute T cell leukemia heart failure liver disease dermatitis, atopic susceptibility to HIV infection lymphoproliferative syndrome toxic epidermal necrolysis Pontiac fever cancer malignant pancreatic neoplasm arthritic joint disease ulcerative colitis drug-induced liver injury mesothelioma respiratory system disease ileocolitis X-linked lymphoproliferative syndrome common variable immunodeficiency eyelid disease autism schizophrenia nasopharyngeal carcinoma benign mesothelioma cutaneous melanoma lymphatic system disease AIDS paranoid schizophrenia major depressive disorder hepatocellular carcinoma tuberous sclerosis 1 psoriasis type 1 diabetes mellitus
C, D, E	Pharos: P15260	autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency endometriosis immunodeficiency 27A hepatitis B virus infection Liver Cirrhosis, Experimental lung cancer mycobacterium tuberculosis, susceptibility to myopathy pancreatic ductal adenocarcinoma astrocytic tumor coronary artery disease lung carcinoma osteosarcoma plasma cell myeloma Down syndrome autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial IFNgammaR1 deficiency endometriosis immunodeficiency 27A hepatitis B virus infection Liver Cirrhosis, Experimental lung cancer mycobacterium tuberculosis, susceptibility to myopathy pancreatic ductal adenocarcinoma astrocytic tumor coronary artery disease lung carcinoma osteosarcoma plasma cell myeloma Down syndrome esophageal adenocarcinoma Helicobacter pylori infection, susceptibility to hereditary spastic paraplegia inherited susceptibility to mycobacterial diseases lung adenocarcinoma mendelian susceptibility to mycobacterial diseases due to complete IFNgammaR1 deficiency myocardial ischemia ovarian cancer Sjogren syndrome B-cell chronic lymphocytic leukemia glioblastoma Helicobacter pylori infectious disease IgA glomerulonephritis juvenile dermatomyositis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.