Annotations: 1FDH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fdha_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d1fdhb_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, alpha-chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth G]	d1fdhg_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth H]	d1fdhh_	All alpha proteins	Globin-like	Globin-like	Globins	Hemoglobin, beta-chain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Globin-like	8039836	3000554	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Globin-like	8039836	3000554	SCOP2B (2022-06-29)
B [auth G]	SCOP2B Superfamily	Globin-like	8060998	3000554	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	Globin-like	8060998	3000554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Globin	e1fdhA1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
C [auth B]	Globin	e1fdhB1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
B [auth G]	Globin	e1fdhG1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
D [auth H]	Globin	e1fdhH1	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
C [auth B]	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
B [auth G]	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
D [auth H]	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00042	Globin (Globin)	Globin	-	Domain
B [auth G], D [auth H]	PF00042	Globin (Globin)	Globin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	HEMOGLOBIN F (DEOXY) (ALPHA CHAIN)	oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding organic acid binding	cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport organic substance transport carbon dioxide transport nitric oxide transport nitrogen compound transport response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species response to inorganic substance cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex intracellular anatomical structure hemoglobin complex cytoplasm cellular anatomical entity cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex intracellular anatomical structure hemoglobin complex cytoplasm cellular anatomical entity cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen endocytic vesicle lumen endocytic vesicle
B [auth G], D [auth H]	HEMOGLOBIN F (DEOXY) (GAMMA CHAIN)	oxygen binding binding small molecule binding hemoglobin binding protein binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding oxygen binding binding small molecule binding hemoglobin binding protein binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding metal ion binding	cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport cellular catabolic process catabolic process cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport organic substance transport carbon dioxide transport cellular response to stimulus cellular detoxification cellular response to chemical stimulus response to stimulus response to chemical detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex intracellular anatomical structure hemoglobin complex cytoplasm cellular anatomical entity cytosol haptoglobin-hemoglobin complex extracellular region extracellular space blood microparticle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR002338	Hemoglobin, alpha-type	Family
A, C [auth B]	IPR002339	Hemoglobin, pi	Family
A, C [auth B]	IPR009050	Globin-like superfamily	Homologous Superfamily
A, C [auth B]	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, C [auth B]	IPR000971	Globin	Domain
B [auth G], D [auth H]	IPR009050	Globin-like superfamily	Homologous Superfamily
B [auth G], D [auth H]	IPR012292	Globin/Protoglobin	Homologous Superfamily
B [auth G], D [auth H]	IPR002337	Hemoglobin, beta-type	Family
B [auth G], D [auth H]	IPR000971	Globin	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C [auth B]	Pharos: P69905	alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 sarcomatoid carcinoma carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder mammary neoplasms, animal thalassemia congenital anemia facioscapulohumeral muscular dystrophy familial polycythemia hydrops fetalis lung adenocarcinoma beta thalassemia sickle cell anemia Hb Bart's hydrops fetalis hemoglobin M disease maturity-onset diabetes of the young breast carcinoma undifferentiated carcinoma diabetes mellitus
B [auth G], D [auth H]	Pharos: P69892	cyanosis, transient neonatal Oliguria prostate cancer acute kidney failure congenital anemia hereditary persistence of fetal hemoglobin malaria hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth G], D [auth H]	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.