1F2V

CRYSTAL STRUCTURE ANALYSIS OF PRECORRIN-8X METHYLMUTASE OF AEROBIC VITAMIN B12 SYNTHESIS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1f2va_	Alpha and beta proteins (a/b)	Flavodoxin-like	Precorrin-8X methylmutase CbiC/CobH	Precorrin-8X methylmutase CbiC/CobH	Precorrin-8x methylmutase	(Pseudomonas denitrificans (nom. rej.) ) [TaxId: 43306 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Precorrin-8X methylmutase CbiC/CobH	8020532	4003365	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Precorrin-8X methylmutase CbiC/CobH	8032912	3000708	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02570	e1f2vA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Precorrin-8X methylmutase CbiC/CobH (From Topology)	T: Precorrin-8X methylmutase CbiC/CobH	F: PF02570	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.10230	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Cobalamin biosynthesis CobH/CbiC, precorrin-8X methylmutase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02570	Precorrin-8X methylmutase (CbiC)	Precorrin-8X methylmutase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PRECORRIN-8X METHYLMUTASE	isomerase activity precorrin-8X methylmutase activity intramolecular acyltransferase activity catalytic activity intramolecular transferase activity	cobalamin metabolic process cobalamin biosynthetic process water-soluble vitamin biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process vitamin biosynthetic process vitamin metabolic process organic cyclic compound metabolic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process cobalamin metabolic process cobalamin biosynthetic process water-soluble vitamin biosynthetic process organonitrogen compound metabolic process tetrapyrrole metabolic process small molecule biosynthetic process cellular biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process vitamin biosynthetic process vitamin metabolic process organic cyclic compound metabolic process organic substance metabolic process tetrapyrrole biosynthetic process biosynthetic process organic cyclic compound biosynthetic process organic substance biosynthetic process small molecule metabolic process metabolic process cellular process water-soluble vitamin metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003722	Cobalamin biosynthesis precorrin-8X methylmutase CobH/CbiC	Domain
A	IPR036588	Precorrin-8X methylmutase CobH/CbiC superfamily	Homologous Superfamily

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	precorrin-8X methylmutase M-CSA #193	Precorrin-8x methyl mutase (CobH) catalyses the migration of a methyl group attached to C-11 of the substrate, precorrin-8x, to the adjacent C-12 to give the product hydrogenobyrinic acid (HBA).This is a step in the aerobic biosynthesis of the corrin macrocycle of vitamin B12.	Defined by 1 residue: HIS:A-52 [auth A-43] \| Explore in 3D: M-CSA Motif Definition At least 2 residues must be present to support Structure Motif searching. EC: 5.4.1.2 (PDB Primary Data)

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.