Annotations: 1EYF

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1eyfa_	Small proteins	Ada DNA repair protein, N-terminal domain (N-Ada 10)	Ada DNA repair protein, N-terminal domain (N-Ada 10)	Ada DNA repair protein, N-terminal domain (N-Ada 10)	Ada DNA repair protein, N-terminal domain (N-Ada 10)	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ada DNA repair protein N-terminal domain (N-Ada 10)	8023318	4003758	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ada DNA repair protein N-terminal domain (N-Ada 10)	8035698	3001437	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02805	e1eyfA1	A: few secondary structure elements	X: Ada DNA repair protein, N-terminal domain (N-Ada 10) (From Topology)	H: Ada DNA repair protein, N-terminal domain (N-Ada 10) (From Topology)	T: Ada DNA repair protein, N-terminal domain (N-Ada 10)	F: PF02805	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.10.10	Alpha Beta	3-Layer(aba) Sandwich	DNA Methylphosphotriester Repair Domain	DNA Methylphosphotriester Repair Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02805	Metal binding domain of Ada (Ada_Zn_binding)	Metal binding domain of Ada	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ADA REGULATORY PROTEIN	catalytic activity, acting on a protein transferase activity, transferring one-carbon groups S-methyltransferase activity protein methyltransferase activity methylated-DNA-[protein]-cysteine S-methyltransferase activity transferase activity methyltransferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity cation binding transition metal ion binding zinc ion binding ion binding catalytic activity, acting on a protein transferase activity, transferring one-carbon groups S-methyltransferase activity protein methyltransferase activity methylated-DNA-[protein]-cysteine S-methyltransferase activity transferase activity methyltransferase activity catalytic activity transcription regulator activity DNA-binding transcription factor activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process DNA metabolic process DNA modification DNA demethylation DNA dealkylation macromolecule modification demethylation methylation DNA alkylation repair DNA repair	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR008332	Methylguanine DNA methyltransferase, ribonuclease-like domain	Domain
A	IPR036217	Methylated DNA-protein cysteine methyltransferase, DNA binding domain	Homologous Superfamily
A	IPR018060	DNA binding HTH domain, AraC-type	Domain
A	IPR035451	Ada-like domain superfamily	Homologous Superfamily
A	IPR018062	HTH domain AraC-type, conserved site	Conserved Site
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A	IPR036631	Methylated DNA-protein cysteine methyltransferase domain superfamily	Homologous Superfamily
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR014048	Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding	Domain
A	IPR001497	Methylated-DNA-[protein]-cysteine S-methyltransferase, active site	Active Site
A	IPR016221	Bifunctional regulatory protein Ada	Family
A	IPR004026	Ada DNA repair, metal-binding	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.