1EMH

CRYSTAL STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO UNCLEAVED SUBSTRATE-CONTAINING DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1emha_	Alpha and beta proteins (a/b)	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase-like	Uracil-DNA glycosylase	Uracil-DNA glycosylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Uracil-DNA glycosylase-like	8042482	3001106	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	UDG	e1emhA1	A: a/b three-layered sandwiches	X: Uracil-DNA glycosylase-like (From Topology)	H: Uracil-DNA glycosylase-like (From Topology)	T: Uracil-DNA glycosylase-like	F: UDG	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.40.470.10	Alpha Beta	3-Layer(aba) Sandwich	Uracil-DNA Glycosylase, subunit E	Uracil-DNA glycosylase-like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A]	PF03167	Uracil DNA glycosylase superfamily (UDG)	Uracil DNA glycosylase superfamily	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	DNA (5'-D(TPGPTP(P2U)PAPTPCPTP*T)-3')	-	-	-
B [auth C]	DNA (5'-D(APAPAPGPAPTPAPAPCPA)-3')	-	-	-
C [auth A]	URACIL-DNA GLYCOSYLASE	uracil DNA N-glycosylase activity hydrolase activity, acting on glycosyl bonds deaminated base DNA N-glycosylase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid hydrolase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding uracil DNA N-glycosylase activity hydrolase activity, acting on glycosyl bonds deaminated base DNA N-glycosylase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid hydrolase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding ribonucleoprotein complex binding protein-containing complex binding ribosomal small subunit binding ribosome binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process base-excision repair organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains multicellular organismal process lymphocyte mediated immunity B cell activation involved in immune response cell activation involved in immune response multicellular organism development anatomical structure development organic substance biosynthetic process leukocyte mediated immunity somatic diversification of immune receptors somatic recombination of immunoglobulin genes involved in immune response system development developmental process immune response DNA recombination cellular metabolic process immune effector process somatic diversification of immunoglobulins biosynthetic process B cell mediated immunity isotype switching immune system development immunoglobulin production immunoglobulin production involved in immunoglobulin-mediated immune response cellular biosynthetic process somatic cell DNA recombination lymphocyte activation leukocyte activation somatic diversification of immunoglobulins involved in immune response somatic recombination of immunoglobulin gene segments leukocyte activation involved in immune response lymphocyte activation involved in immune response production of molecular mediator of immune response B cell activation cell activation gene expression macromolecule biosynthetic process immunoglobulin mediated immune response adaptive immune response immune system process somatic diversification of immune receptors via germline recombination within a single locus deoxyribonucleotide catabolic process pyrimidine deoxyribonucleotide metabolic process pyrimidine-containing compound catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process pyrimidine nucleotide metabolic process DNA modification phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process pyrimidine-containing compound metabolic process nucleotide metabolic process nucleobase-containing compound catabolic process macromolecule modification base-excision repair, AP site formation pyrimidine deoxyribonucleotide catabolic process catabolic process deoxyribose phosphate catabolic process pyrimidine nucleotide catabolic process deoxyribonucleotide metabolic process nucleobase-containing small molecule metabolic process depyrimidination nucleotide catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process 2'-deoxyribonucleotide metabolic process deoxyribose phosphate metabolic process organic cyclic compound catabolic process organophosphate metabolic process organic substance catabolic process somatic diversification of immune receptors via somatic mutation somatic hypermutation of immunoglobulin genes base-excision repair, AP site formation via deaminated base removal	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A]	IPR036895	Uracil-DNA glycosylase-like domain superfamily	Homologous Superfamily
C [auth A]	IPR002043	Uracil-DNA glycosylase family 1	Family
C [auth A]	IPR018085	Uracil-DNA glycosylase, active site	Active Site
C [auth A]	IPR005122	Uracil-DNA glycosylase-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth A]	Pharos: P13051	Bloom syndrome colorectal cancer hyper-IgM syndrome type 1 hyper-IgM syndrome type 5 acute myeloid leukemia Hyper-IgM Immunodeficiency Syndrome, Type 2 hyper-IgM syndrome large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer colorectal carcinoma lung cancer non-small cell lung carcinoma cervical cancer medulloblastoma Bloom syndrome colorectal cancer hyper-IgM syndrome type 1 hyper-IgM syndrome type 5 acute myeloid leukemia Hyper-IgM Immunodeficiency Syndrome, Type 2 hyper-IgM syndrome large cell medulloblastoma nasopharyngeal carcinoma ovarian cancer colorectal carcinoma lung cancer non-small cell lung carcinoma cervical cancer medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.