1EK5

STRUCTURE OF HUMAN UDP-GALACTOSE 4-EPIMERASE IN COMPLEX WITH NAD+

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ek5a_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Uridine diphosphogalactose-4-epimerase (UDP-galactose 4-epimerase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SDR-like	8058493	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF16363	e1ek5A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF16363	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.25.10	Alpha Beta	Alpha-Beta Complex	UDP-galactose 4-epimerase	domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF16363	GDP-mannose 4,6 dehydratase (GDP_Man_Dehyd)	GDP-mannose 4,6 dehydratase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	UDP-GALACTOSE 4-EPIMERASE	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity isomerase activity racemase and epimerase activity UDP-N-acetylglucosamine 4-epimerase activity racemase and epimerase activity, acting on carbohydrates and derivatives catalytic activity UDP-glucose 4-epimerase activity	monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process hexose metabolic process primary metabolic process galactose metabolic process organic substance metabolic process small molecule metabolic process metabolic process monosaccharide catabolic process small molecule catabolic process monosaccharide metabolic process carbohydrate metabolic process catabolic process hexose catabolic process carbohydrate catabolic process galactose catabolic process hexose metabolic process primary metabolic process galactose metabolic process organic substance metabolic process small molecule metabolic process metabolic process monosaccharide catabolic process small molecule catabolic process organic substance catabolic process galactose catabolic process via UDP-galactose	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005886	UDP-glucose 4-epimerase	Family
A	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A	IPR016040	NAD(P)-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14376	galactosemia galactose epimerase deficiency galactokinase deficiency tinea pedis breast cancer dermatophytosis of groin and perianal area intellectual disability malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis UDPglucose 4-epimerase deficiency disease breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma galactosemia galactose epimerase deficiency galactokinase deficiency tinea pedis breast cancer dermatophytosis of groin and perianal area intellectual disability malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma psoriasis UDPglucose 4-epimerase deficiency disease breast carcinoma ductal breast carcinoma in situ interstitial cystitis osteosarcoma pancreatic intraductal papillary-mucinous neoplasm tinea corporis inborn errors of metabolism invasive ductal breast carcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.