1EFN

HIV-1 NEF PROTEIN IN COMPLEX WITH R96I MUTANT FYN SH3 DOMAIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1efnc_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	Fyn proto-oncogene tyrosine kinase, SH3 domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1efna_	All beta proteins	SH3-like barrel	SH3-domain	SH3-domain	Fyn proto-oncogene tyrosine kinase, SH3 domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1efnb_	Alpha and beta proteins (a+b)	Regulatory factor Nef	Regulatory factor Nef	Regulatory factor Nef	Regulatory factor Nef	(Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)
D	d1efnd_	Alpha and beta proteins (a+b)	Regulatory factor Nef	Regulatory factor Nef	Regulatory factor Nef	Regulatory factor Nef	(Human immunodeficiency virus 1 ) [TaxId: 11676 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	SH3-domain	8041562	3000153	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	SH3-domain	8041562	3000153	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	SH3_1	e1efnC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
A	SH3_1	e1efnA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: SH3_1	ECOD (1.6)
B	F-protein	e1efnB1	A: a+b three layers	X: Regulatory factor Nef (From Topology)	H: Regulatory factor Nef (From Topology)	T: Regulatory factor Nef	F: F-protein	ECOD (1.6)
D	F-protein	e1efnD1	A: a+b three layers	X: Regulatory factor Nef (From Topology)	H: Regulatory factor Nef (From Topology)	T: Regulatory factor Nef	F: F-protein	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
B	3.30.62.10	Alpha Beta	2-Layer Sandwich	Nef Regulatory Factor	Nef Regulatory Factor	CATH (4.3.0)
D	3.30.62.10	Alpha Beta	2-Layer Sandwich	Nef Regulatory Factor	Nef Regulatory Factor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
B, D	PF00469	Negative factor, (F-Protein) or Nef (F-protein)	Negative factor, (F-Protein) or Nef	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	FYN TYROSINE KINASE	protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cytoskeletal protein binding protein binding binding tubulin binding alpha-tubulin binding adenyl ribonucleotide binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cytoskeletal protein binding protein binding binding tubulin binding alpha-tubulin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity signaling receptor binding ephrin receptor binding cation binding metal ion binding growth factor receptor binding scaffold protein binding type 5 metabotropic glutamate receptor binding glutamate receptor binding G protein-coupled receptor binding G protein-coupled glutamate receptor binding tau-protein kinase activity tau protein binding identical protein binding phospholipase binding enzyme binding transmembrane transporter binding enzyme regulator activity enzyme activator activity molecular function activator activity phospholipase activator activity molecular function regulator activity lipase activator activity disordered domain specific binding protein domain specific binding	regulation of calcium ion transport regulation of localization import into cell regulation of cellular process transport monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport calcium ion import into cytosol regulation of calcium ion transport regulation of localization import into cell regulation of cellular process transport monoatomic ion transmembrane transport regulation of monoatomic ion transmembrane transport calcium ion transport metal ion transport regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport calcium ion import into cytosol monoatomic cation transport regulation of metal ion transport regulation of calcium ion import regulation of biological process calcium ion transmembrane import into cytosol regulation of transport regulation of monoatomic ion transport import across plasma membrane biological regulation inorganic ion transmembrane transport establishment of localization inorganic cation import across plasma membrane inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport calcium ion import across plasma membrane regulation of calcium ion import across plasma membrane inorganic ion import across plasma membrane cellular process regulation of monoatomic cation transmembrane transport calcium ion import calcium ion transmembrane transport regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of biological process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process macromolecule metabolic process regulation of metabolic process organonitrogen compound catabolic process catabolic process protein catabolic process macromolecule catabolic process organic substance catabolic process regulation of neuron projection development multicellular organismal process regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization protein phosphorylation phosphorylation cellular metabolic process macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process inflammatory response to antigenic stimulus response to stress regulation of response to stress regulation of immune system process negative regulation of inflammatory response to antigenic stimulus defense response immune response negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus response to external stimulus regulation of inflammatory response regulation of response to stimulus negative regulation of immune system process immune system process negative regulation of response to external stimulus negative regulation of defense response regulation of immune response inflammatory response response to oxidative stress response to singlet oxygen response to chemical response to oxygen-containing compound response to reactive oxygen species response to inorganic substance detection of external stimulus detection of stimulus involved in sensory perception of pain system process detection of mechanical stimulus involved in sensory perception of pain nervous system process response to mechanical stimulus sensory perception of pain detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception reactive oxygen species biosynthetic process cellular biosynthetic process reactive oxygen species metabolic process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process regulation of hydrogen peroxide metabolic process negative regulation of cellular process regulation of biosynthetic process regulation of hydrogen peroxide biosynthetic process negative regulation of metabolic process hydrogen peroxide metabolic process regulation of cellular metabolic process hydrogen peroxide biosynthetic process regulation of reactive oxygen species biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process negative regulation of hydrogen peroxide metabolic process biosynthetic process negative regulation of biosynthetic process negative regulation of hydrogen peroxide biosynthetic process regulation of reactive oxygen species metabolic process head development forebrain development animal organ development brain development central nervous system development dendritic spine maintenance dendritic spine organization postsynapse organization cellular component maintenance cell junction organization neuron projection organization synapse organization axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron projection guidance leukocyte migration cell migration cell motility cellular response to stimulus signaling signal transduction intracellular signal transduction cell communication organic substance biosynthetic process negative regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of signaling cell surface receptor signaling pathway regulation of signal transduction glutamate receptor signaling pathway regulation of glutamate receptor signaling pathway regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway vascular endothelial growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to endogenous stimulus response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to organic substance response to amyloid-beta immune response-regulating cell surface receptor signaling pathway involved in phagocytosis immune response-regulating cell surface receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis vesicle-mediated transport positive regulation of response to stimulus immune response-activating signaling pathway Fc receptor signaling pathway immune response-regulating signaling pathway positive regulation of immune response phagocytosis Fc-gamma receptor signaling pathway positive regulation of immune system process immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway immune effector process endocytosis activation of immune response behavior learning learning or memory cognition adaptive immune response negative regulation of post-translational protein modification regulation of protein modification process regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal ephrin receptor signaling pathway regulation of protein phosphorylation peptidyl-tyrosine modification regulation of phosphate metabolic process peptidyl-amino acid modification regulation of peptidyl-tyrosine phosphorylation regulation of phosphorylation regulation of phosphorus metabolic process peptidyl-tyrosine phosphorylation biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus protein localization cellular localization regulation of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization regulation of protein localization to membrane trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling cellular response to acid chemical cellular response to amino acid stimulus cellular response to L-glutamate response to amino acid response to acid chemical response to L-glutamate regulation of dendritic spine maintenance regulation of synapse structure or activity regulation of biological quality negative regulation of cell projection organization negative regulation of dendritic spine maintenance negative regulation of cellular component organization regulation of postsynapse organization regulation of synapse organization regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process T cell costimulation regulation of lymphocyte activation negative regulation of protein catabolic process negative regulation of catabolic process regulation of catabolic process regulation of protein catabolic process establishment of protein localization protein targeting positive regulation of establishment of protein localization regulation of protein targeting to membrane establishment of protein localization to membrane regulation of establishment of protein localization protein targeting to membrane regulation of protein targeting positive regulation of protein targeting to membrane positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus protein localization to organelle T cell receptor signaling pathway antigen receptor-mediated signaling pathway cellular response to growth factor stimulus cellular response to platelet-derived growth factor stimulus response to growth factor response to platelet-derived growth factor response to transforming growth factor beta cellular response to transforming growth factor beta stimulus heart process circulatory system process dendrite development dendrite morphogenesis positive regulation of response to biotic stimulus innate immune response-activating signaling pathway regulation of innate immune response response to lectin cellular response to lectin positive regulation of defense response activation of innate immune response regulation of response to biotic stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus positive regulation of innate immune response stimulatory C-type lectin receptor signaling pathway feeding behavior response to alcohol response to ethanol regulation of developmental process regulation of cell shape regulation of cell morphogenesis regulation of anatomical structure morphogenesis cellular response to oxidative stress cellular response to chemical stress cellular response to hydrogen peroxide response to hydrogen peroxide cellular response to reactive oxygen species cellular response to stress intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of signaling negative regulation of intracellular signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway negative regulation of cell communication regulation of intracellular signal transduction negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of programmed cell death regulation of apoptotic process negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway cell death negative regulation of signal transduction apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway response to glycine cellular response to glycine positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein positive regulation of phosphorus metabolic process cell surface receptor signaling pathway via STAT positive regulation of cellular metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process regulation of tyrosine phosphorylation of STAT protein positive regulation of tyrosine phosphorylation of STAT protein cell surface receptor signaling pathway via JAK-STAT neuron migration cell population proliferation leukocyte proliferation activated T cell proliferation mononuclear cell proliferation lymphocyte proliferation T cell proliferation	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane polymeric cytoskeletal fiber actin filament actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle membrane microdomain membrane raft membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system cytoplasmic vesicle vesicle Schaffer collateral - CA1 synapse synapse cell junction cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection perinuclear endoplasmic reticulum perinuclear region of cytoplasm endoplasmic reticulum mitochondrion glial cell projection postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse nucleus
B, D	HIV-1 NEF PROTEIN	protein binding binding signaling receptor binding thioesterase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding protein binding binding signaling receptor binding thioesterase binding enzyme binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding SH3 domain binding protein domain specific binding CD4 receptor binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity kinase binding protein kinase binding calmodulin binding MHC class I protein binding MHC protein binding ATPase binding	viral process viral life cycle symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response viral process viral life cycle symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host immune response modulation by symbiont of host process response to host immune response symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I symbiont-mediated suppression of host antigen processing and presentation response to host response to external biotic stimulus modulation of process of another organism symbiont-mediated suppression of host adaptive immune response symbiont-mediated suppression of host T-cell mediated immune response multicellular organismal process regulation of biological process regulation of cellular process regulation of leukocyte activation cell activation biological regulation regulation of cell activation regulation of T cell activation lymphocyte activation leukocyte activation T cell activation immune system process cellular process regulation of multicellular organismal process regulation of immune system process regulation of lymphocyte activation regulation of CD4 production cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process regulation of glycoprotein biosynthetic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process carbohydrate derivative biosynthetic process regulation of biosynthetic process negative regulation of glycoprotein biosynthetic process negative regulation of glycoprotein metabolic process organonitrogen compound metabolic process negative regulation of CD4 production cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process glycoprotein biosynthetic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process glycoprotein metabolic process macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of glycoprotein metabolic process regulation of cellular biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process CD4 biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus regulation of signaling signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication signal transduction modulation by virus of host process virus-mediated perturbation of host defense response perturbation by virus of host immune response modulation by virus of host cellular process suppression by virus of host autophagy modulation by virus of host autophagy symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane extracellular region virion component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane extracellular region virion component host intracellular part host cell Golgi membrane host cell Golgi apparatus host cell cytoplasm part host cell cytoplasm host cell endomembrane system host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, C	IPR000719	Protein kinase domain	Domain
A, C	IPR017441	Protein kinase, ATP binding site	Binding Site
A, C	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, C	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, C	IPR035750	Fyn/Yrk, SH3 domain	Domain
A, C	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, C	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, C	IPR001452	SH3 domain	Domain
A, C	IPR047924	Fyn/Yrk, SH2 domain	Domain
A, C	IPR000980	SH2 domain	Domain
A, C	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D	IPR001558	HIV negative factor Nef	Family
B, D	IPR027481	HIV-1 Nef protein, core domain superfamily	Homologous Superfamily
B, D	IPR027480	HIV-1 Nef protein, anchor domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P06241	adult T-cell leukemia/lymphoma Liver Cirrhosis, Experimental mature T-cell and NK-cell non-Hodgkin lymphoma psoriasis Sjogren syndrome gastric neoplasm tuberculosis hereditary diffuse gastric adenocarcinoma invasive ductal breast carcinoma malignant mesothelioma acute T cell leukemia non-small cell lung carcinoma attention deficit hyperactivity disorder, inattentive type pancreatic ductal adenocarcinoma cystic fibrosis adult T-cell leukemia/lymphoma Liver Cirrhosis, Experimental mature T-cell and NK-cell non-Hodgkin lymphoma psoriasis Sjogren syndrome gastric neoplasm tuberculosis hereditary diffuse gastric adenocarcinoma invasive ductal breast carcinoma malignant mesothelioma acute T cell leukemia non-small cell lung carcinoma attention deficit hyperactivity disorder, inattentive type pancreatic ductal adenocarcinoma cystic fibrosis pulmonary hypertension esophageal adenocarcinoma skin disease glioblastoma ulcerative colitis idiopathic interstitial pneumonia juvenile dermatomyositis lung cancer medulloblastoma oligodendroglioma B-cell chronic lymphocytic leukemia pancreatic intraductal papillary-mucinous neoplasm breast fibroadenoma psoriatic arthritis Down syndrome schizophrenia gastric cancer squamous cell lung carcinoma Hashimoto thyroiditis interstitial cystitis large cell medulloblastoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm alcohol abuse metastatic melanoma astrocytic tumor ovarian cancer bipolar disorder cancer pilocytic astrocytoma pulmonary fibrosis ductal breast carcinoma in situ

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.