1EAV

Crystal Structures of Human Gephyrin and Plant Cnx1 G domains - Comparative Analysis and Functional Implications

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1eava_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
B	d1eavb_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
C	d1eavc_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
D	d1eavd_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
E	d1eave_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
F	d1eavf_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
G	d1eavg_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)
H	d1eavh_	Alpha and beta proteins (a/b)	Molybdenum cofactor biosynthesis proteins	Molybdenum cofactor biosynthesis proteins	MogA-like	Plant CNX1 G domain	MOUSE-EAR CRESS (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Molybdenum cofactor biosynthesis proteins	8040936	3000702	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MoCF_biosynth	e1eavA1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
B	MoCF_biosynth	e1eavB1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
C	MoCF_biosynth	e1eavC1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
D	MoCF_biosynth	e1eavD1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
E	MoCF_biosynth	e1eavE1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
F	MoCF_biosynth	e1eavF1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
G	MoCF_biosynth	e1eavG1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)
H	MoCF_biosynth	e1eavH1	A: a/b three-layered sandwiches	X: Molybdenum cofactor biosynthesis proteins (From Topology)	H: Molybdenum cofactor biosynthesis proteins (From Topology)	T: Molybdenum cofactor biosynthesis proteins	F: MoCF_biosynth	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
B	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
C	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
D	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
E	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
F	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
G	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)
H	3.40.980.10	Alpha Beta	3-Layer(aba) Sandwich	Molybdenum Cofactor Biosythetic Enzyme	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00994	Probable molybdopterin binding domain (MoCF_biosynth)	Probable molybdopterin binding domain	This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyr ...	This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding molybdopterin molybdotransferase activity transferase activity catalytic activity nitrate reductase activity oxidoreductase activity oxidoreductase activity, acting on other nitrogenous compounds as donors cation binding transition metal ion binding molybdenum ion binding metal ion binding adenylyltransferase activity molybdopterin adenylyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups	response to stimulus response to metal ion response to chemical response to inorganic substance auxin-activated signaling pathway cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process signaling response to endogenous stimulus biological regulation hormone-mediated signaling pathway cellular response to auxin stimulus response to stimulus response to metal ion response to chemical response to inorganic substance auxin-activated signaling pathway cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process signaling response to endogenous stimulus biological regulation hormone-mediated signaling pathway cellular response to auxin stimulus cell communication response to auxin cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone cellular process cellular response to organic substance signal transduction cellular response to hormone stimulus organonitrogen compound metabolic process Mo-molybdopterin cofactor biosynthetic process Mo-molybdopterin cofactor metabolic process cellular metabolic process organonitrogen compound biosynthetic process primary metabolic process prosthetic group metabolic process molybdopterin cofactor biosynthetic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process molybdopterin cofactor metabolic process organic cyclic compound biosynthetic process phosphate-containing compound metabolic process organic substance biosynthetic process metabolic process protein metabolic process macromolecule metabolic process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005111	MoeA, C-terminal, domain IV	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036425	MoaB/Mog-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR008284	Molybdenum cofactor biosynthesis, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036688	MoeA, C-terminal, domain IV superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001453	MoaB/Mog domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005110	MoeA, N-terminal and linker domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR038987	Molybdopterin biosynthesis protein MoeA-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036135	MoeA, N-terminal and linker domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.