Annotations: 1E3S

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1e3sa_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Type II 3-hydroxyacyl-CoA dehydrogenase	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D	d1e3sd_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Type II 3-hydroxyacyl-CoA dehydrogenase	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1e3sb_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Type II 3-hydroxyacyl-CoA dehydrogenase	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C	d1e3sc_	Alpha and beta proteins (a/b)	NAD(P)-binding Rossmann-fold domains	NAD(P)-binding Rossmann-fold domains	Tyrosine-dependent oxidoreductases	Type II 3-hydroxyacyl-CoA dehydrogenase	NORWAY RAT (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SDR-like	8057153	3000038	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	SDR-like	8057153	3000038	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SDR-like	8057153	3000038	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SDR-like	8057153	3000038	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00106	e1e3sA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00106	ECOD (1.6)
D	PF00106	e1e3sD1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00106	ECOD (1.6)
B	PF00106	e1e3sB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00106	ECOD (1.6)
C	PF00106	e1e3sC1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: PF00106	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
D	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
C	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	SHORT CHAIN 3-HYDROXYACYL-COA DEHYDROGENASE	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity catalytic activity steroid dehydrogenase activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity testosterone dehydrogenase [NAD(P)] activity testosterone dehydrogenase (NAD+) activity amide binding amyloid-beta binding binding peptide binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity catalytic activity steroid dehydrogenase activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity testosterone dehydrogenase [NAD(P)] activity testosterone dehydrogenase (NAD+) activity amide binding amyloid-beta binding binding peptide binding 3-hydroxyacyl-CoA dehydrogenase activity 17-beta-hydroxysteroid dehydrogenase (NAD+) activity RNA binding organic cyclic compound binding tRNA binding nucleic acid binding chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity androstan-3-alpha,17-beta-diol dehydrogenase activity estradiol 17-beta-dehydrogenase [NAD(P)] activity ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity acetoacetyl-CoA reductase activity steroid binding lipid binding NAD binding nucleoside phosphate binding purine nucleotide binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding cholate 7-alpha-dehydrogenase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor binding nuclear estrogen receptor binding identical protein binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development cellular developmental process cell differentiation cellular process Leydig cell differentiation regulation of hormone levels steroid metabolic process biological regulation androgen metabolic process primary metabolic process hormone metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process regulation of biological quality lipid metabolic process catabolic process oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process cellular catabolic process monocarboxylic acid catabolic process fatty acid oxidation carboxylic acid catabolic process fatty acid beta-oxidation small molecule metabolic process lipid oxidation fatty acid metabolic process lipid catabolic process cellular metabolic process carboxylic acid metabolic process lipid modification fatty acid catabolic process cellular lipid metabolic process monocarboxylic acid metabolic process small molecule catabolic process organic substance catabolic process estrogen metabolic process protein-containing complex organization protein homotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis mitochondrial tRNA modification cellular biosynthetic process RNA metabolic process mitochondrial gene expression nucleobase-containing compound metabolic process mitochondrial RNA processing tRNA processing organic substance biosynthetic process mitochondrial RNA modification tRNA threonylcarbamoyladenosine metabolic process RNA processing mitochondrial tRNA methylation mitochondrial tRNA processing tRNA modification gene expression macromolecule biosynthetic process nucleic acid metabolic process macromolecule methylation tRNA metabolic process RNA modification biosynthetic process methylation macromolecule modification ncRNA metabolic process nucleic acid catabolic process macromolecule metabolic process mitochondrial RNA metabolic process RNA methylation tRNA methylation organic hydroxy compound metabolic process lipid biosynthetic process organic acid biosynthetic process carboxylic acid biosynthetic process steroid biosynthetic process bile acid biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process bile acid metabolic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process amino acid metabolic process alpha-amino acid metabolic process branched-chain amino acid catabolic process branched-chain amino acid metabolic process isoleucine catabolic process amino acid catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process alpha-amino acid catabolic process isoleucine metabolic process brexanolone metabolic process cellular ketone metabolic process C21-steroid hormone metabolic process mitochondrial tRNA 5'-end processing tRNA 5'-end processing mitochondrial RNA 5'-end processing RNA 5'-end processing mitochondrial tRNA 3'-end processing RNA 3'-end processing tRNA 3'-end processing mitochondrial RNA 3'-end processing organelle organization mitochondrion organization	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex methyltransferase complex transferase complex tRNA methyltransferase complex mitochondrial protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex catalytic complex methyltransferase complex transferase complex tRNA methyltransferase complex mitochondrial protein-containing complex ribonuclease P complex endonuclease complex endoribonuclease complex ribonucleoprotein complex mitochondrial ribonuclease P complex intracellular protein-containing complex membrane-enclosed lumen nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle mitochondrial nucleoid non-membrane-bounded organelle endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002347	Short-chain dehydrogenase/reductase SDR	Family
A, B, C, D	IPR020904	Short-chain dehydrogenase/reductase, conserved site	Conserved Site
A, B, C, D	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.