Annotations: 1DJL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1djla_	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	Transhydrogenase domain III (dIII)	Transhydrogenase domain III (dIII)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1djlb_	Alpha and beta proteins (a/b)	DHS-like NAD/FAD-binding domain	DHS-like NAD/FAD-binding domain	Transhydrogenase domain III (dIII)	Transhydrogenase domain III (dIII)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Transhydrogenase domain III (dIII)	8031875	4003894	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DHS-like NAD/FAD-binding domain	8044253	3001728	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	DHS-like NAD/FAD-binding domain	8044253	3001728	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02233	e1djlA1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: PF02233	ECOD (1.6)
B	PF02233	e1djlB1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: DHS-like NAD/FAD-binding domain	F: PF02233	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)
B	3.40.50.1220	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	TPP-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02233	NAD(P) transhydrogenase beta subunit (PNTB)	NAD(P) transhydrogenase beta subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	TRANSHYDROGENASE DIII	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor NAD(P)+ transhydrogenase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity NAD(P)+ transhydrogenase (B-specific) activity transmembrane transporter activity catalytic activity binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor NAD(P)+ transhydrogenase activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity NAD(P)+ transhydrogenase (B-specific) activity transmembrane transporter activity catalytic activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding NAD binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process purine nucleotide metabolic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process generation of precursor metabolites and energy nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process organic cyclic compound metabolic process NADPH regeneration organophosphate metabolic process metabolic process reactive oxygen species metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process negative regulation of protein modification process protein metabolic process protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process regulation of mitochondrial membrane potential positive regulation of mitochondrial membrane potential regulation of biological quality positive regulation of membrane potential regulation of membrane potential cellular homeostasis chemical homeostasis homeostatic process intracellular oxygen homeostasis intracellular chemical homeostasis aerobic respiration cellular respiration tricarboxylic acid cycle energy derivation by oxidation of organic compounds positive regulation of hydrogen peroxide catabolic process catabolic process positive regulation of biological process positive regulation of cellular metabolic process regulation of hydrogen peroxide catabolic process cellular catabolic process positive regulation of metabolic process regulation of hydrogen peroxide metabolic process positive regulation of hydrogen peroxide metabolic process positive regulation of cellular process hydrogen peroxide metabolic process regulation of catabolic process positive regulation of reactive oxygen species metabolic process positive regulation of catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process hydrogen peroxide catabolic process regulation of reactive oxygen species metabolic process cell redox homeostasis response to nutrient levels response to stimulus response to chemical response to nutrient response to vitamin cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial respirasome respirasome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR026255	NAD(P) transhydrogenase, alpha subunit	Family
A, B	IPR034300	NADP transhydrogenase beta-like domain	Domain
A, B	IPR008142	Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1	Conserved Site
A, B	IPR029035	DHS-like NAD/FAD-binding domain superfamily	Homologous Superfamily
A, B	IPR007886	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal	Domain
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR024605	NAD(P) transhydrogenase, alpha subunit, C-terminal	Domain
A, B	IPR008143	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2	Conserved Site
A, B	IPR007698	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13423	glucocorticoid deficiency 4 familial glucocorticoid deficiency adrenal cortex carcinoma glucocorticoid deficiency 1 IgA glomerulonephritis malignant mesothelioma ovarian cancer Pick disease Alzheimer disease Familial Glucocorticoid Deficiency Type 1 invasive ductal breast carcinoma pancreatic ductal adenocarcinoma X-linked adrenal hypoplasia congenita dermatomyositis gastric carcinoma glucocorticoid deficiency 4 familial glucocorticoid deficiency adrenal cortex carcinoma glucocorticoid deficiency 1 IgA glomerulonephritis malignant mesothelioma ovarian cancer Pick disease Alzheimer disease Familial Glucocorticoid Deficiency Type 1 invasive ductal breast carcinoma pancreatic ductal adenocarcinoma X-linked adrenal hypoplasia congenita dermatomyositis gastric carcinoma hereditary spastic paraplegia lung adenocarcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	NAD(P)+ transhydrogenase (Re/Si-specific) M-CSA #496	NAD(P) transhydrogenase, a tetramer composed of 2 alpha and 2 beta subunits, is an integral membrane protein that couples the proton transport across the membrane to the reversible transfer of hydride ion equivalents between NAD and NADP. The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland.	Defined by 3 residues: TYR:A-54 [auth A-890]ARG:A-89 [auth A-925]TYR:A-170 [auth A-1006] \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.6.1.1 (PDB Primary Data) Search M-CSA Motif + EC 1.6.1.1

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.