1DH3

CRYSTAL STRUCTURE OF A CREB BZIP-CRE COMPLEX REVEALS THE BASIS FOR CREB FAIMLY SELECTIVE DIMERIZATION AND DNA BINDING

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1dh3a_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	Transcription factor Creb	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D [auth C]	d1dh3c_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	Transcription factor Creb	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2 Family	Leucine zipper domain	8027109	4003836	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	Leucine zipper-like	8039488	3001609	SCOP2 (2022-06-29)
D [auth C]	SCOP2B Superfamily	Leucine zipper-like	8039488	3001609	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D [auth C]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth C]	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth D]	DNA (5'-D(CPCPTPTPGPGPCPTPGPAPCPGPTPCPAPGPCPCPAPAP*G)-3')	-	-	-
C [auth A], D [auth C]	TRANSCRIPTION FACTOR CREB	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding arrestin family protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Hsp70 protein binding protein-folding chaperone binding heat shock protein binding transcription coregulator binding transcription coactivator binding histone acetyltransferase binding enzyme binding	response to stimulus response to chemical response to xenobiotic stimulus response to inorganic substance regulation of protein stability biological regulation regulation of biological quality protein stabilization positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport response to stimulus response to chemical response to xenobiotic stimulus response to inorganic substance regulation of protein stability biological regulation regulation of biological quality protein stabilization positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release positive regulation of cellular process regulation of signaling regulation of biological process regulation of transport secretion regulation of hormone levels export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling response to organic substance chemotaxis taxis chemotaxis to arachidonic acid response to external stimulus locomotion cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of cell size regulation of anatomical structure size response to hormone response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound response to nitrogen compound response to glucagon positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly organic substance metabolic process positive regulation of biosynthetic process protein-containing complex assembly regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II positive regulation of cellular biosynthetic process behavior multicellular organismal process system process learning or memory nervous system process cognition memory cellular response to stimulus response to lipid cellular response to oxygen-containing compound response to retinoic acid cellular response to chemical stimulus cellular response to retinoic acid cellular response to lipid cellular response to organic substance developmental process mammary gland development gland development animal organ development anatomical structure development head development forebrain development endocrine system development pituitary gland development brain development diencephalon development nervous system development multicellular organism development central nervous system development system development axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development response to cytokine response to erythropoietin mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process regulation of body fluid levels body fluid secretion lactation intracellular signal transduction cAMP-mediated signaling intracellular signaling cassette signal transduction fat cell differentiation positive regulation of fat cell differentiation regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of fat cell differentiation regulation of steroid biosynthetic process organic hydroxy compound metabolic process steroid metabolic process regulation of lipid metabolic process lipid biosynthetic process cellular ketone metabolic process regulation of small molecule metabolic process regulation of testosterone biosynthetic process small molecule metabolic process steroid biosynthetic process regulation of cellular ketone metabolic process small molecule biosynthetic process olefinic compound biosynthetic process regulation of ketone biosynthetic process regulation of steroid metabolic process testosterone biosynthetic process organic hydroxy compound biosynthetic process olefinic compound metabolic process regulation of lipid biosynthetic process ketone biosynthetic process lipid metabolic process vesicle organization organelle organization secretory granule organization endomembrane system organization cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway rhythmic process circadian rhythm epithelium development tube development respiratory tube development lung epithelium development type I pneumocyte differentiation tissue development epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation lung development respiratory system development modulation of chemical synaptic transmission long-term synaptic potentiation synaptic signaling positive regulation of long-term synaptic potentiation regulation of synaptic plasticity trans-synaptic signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process regulation of muscle tissue development striated muscle tissue development muscle structure development positive regulation of muscle organ development regulation of cardiac muscle tissue development regulation of multicellular organismal process muscle tissue development muscle organ development positive regulation of cardiac muscle tissue development heart development cardiac muscle tissue development positive regulation of striated muscle tissue development regulation of striated muscle tissue development circulatory system development positive regulation of muscle tissue development regulation of muscle organ development positive regulation of multicellular organismal process positive regulation of transforming growth factor beta3 production regulation of transforming growth factor beta production regulation of transforming growth factor beta3 production cytokine production regulation of cytokine production transforming growth factor beta production transforming growth factor beta3 production positive regulation of gene expression positive regulation of transforming growth factor beta production positive regulation of cytokine production multicellular organismal-level homeostasis homeostatic process inhibition of non-skeletal tissue mineralization anatomical structure homeostasis tissue homeostasis positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process response to light stimulus learning visual learning visual behavior associative learning response to radiation response to abiotic stimulus fibroblast proliferation cell population proliferation regulation of cell population proliferation regulation of fibroblast proliferation lung saccule development lung alveolus development negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of transcription by competitive promoter binding negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to inorganic substance cellular response to metal ion response to zinc ion response to metal ion cellular response to zinc ion regulation of multicellular organism growth regulation of growth regulation of developmental growth developmental growth growth positive regulation of multicellular organism growth multicellular organism growth positive regulation of growth positive regulation of developmental growth myeloid leukocyte differentiation hemopoiesis myeloid cell differentiation osteoclast differentiation leukocyte differentiation response to hepatocyte growth factor cellular response to hepatocyte growth factor stimulus negative regulation of gene expression response to purine-containing compound response to organic cyclic compound regulation of glial cell proliferation gliogenesis glial cell proliferation response to ketone response to alcohol cellular response to forskolin cellular response to organic cyclic compound cellular response to alcohol response to forskolin cellular response to ketone response to leukemia inhibitory factor cellular response to leukemia inhibitory factor cellular response to cytokine stimulus regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of cell development regulation of osteoclast differentiation positive regulation of hemopoiesis regulation of immune system process positive regulation of immune system process regulation of multicellular organismal development regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation	protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle axon cell projection neuron projection protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle axon cell projection neuron projection plasma membrane bounded cell projection RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle ATF4-CREB1 transcription factor complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen euchromatin mitochondrion mitochondrial matrix cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth C]	IPR003102	Cyclic AMP-responsive element-binding protein 1-like, pKID	Domain
C [auth A], D [auth C]	IPR004827	Basic-leucine zipper domain	Domain
C [auth A], D [auth C]	IPR001630	cAMP response element binding (CREB) protein	Family
C [auth A], D [auth C]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.