Annotations: 1DE8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth B]	d1de8b_	Alpha and beta proteins (a+b)	DNase I-like	DNase I-like	DNase I-like	DNA repair endonuclease Hap1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth A]	d1de8a_	Alpha and beta proteins (a+b)	DNase I-like	DNase I-like	DNase I-like	DNA repair endonuclease Hap1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth B]	SCOP2B Superfamily	DNase I-like	8036725	3000957	SCOP2B (2022-06-29)
F [auth A]	SCOP2B Superfamily	DNase I-like	8036725	3000957	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth B]	Exo_endo_phos	e1de8B1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
F [auth A]	Exo_endo_phos	e1de8A1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth B]	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (4.3.0)
F [auth A]	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth B], F [auth A]	PF03372	Endonuclease/Exonuclease/phosphatase family (Exo_endo_phos)	Endonuclease/Exonuclease/phosphatase family	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3. ...	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X], C [auth U]	DNA (5'-D(GPCPTPAPCP(3DR)PGPAPTPCP*G)-3')	-	-	-
B [auth Y], D [auth V]	DNA (5'-D(CPGPAPTPCPGPGPTPAPGP*C)-3')	-	-	-
E [auth B], F [auth A]	MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	DNA-(apurinic or apyrimidinic site) endonuclease activity endonuclease activity catalytic activity, acting on a nucleic acid endodeoxyribonuclease activity, producing 5'-phosphomonoesters hydrolase activity DNA nuclease activity DNA endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on DNA endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity class II DNA-(apurinic or apyrimidinic site) endonuclease activity site-specific endodeoxyribonuclease activity, specific for altered base DNA-(apurinic or apyrimidinic site) endonuclease activity endonuclease activity catalytic activity, acting on a nucleic acid endodeoxyribonuclease activity, producing 5'-phosphomonoesters hydrolase activity DNA nuclease activity DNA endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on DNA endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity class II DNA-(apurinic or apyrimidinic site) endonuclease activity site-specific endodeoxyribonuclease activity, specific for altered base phosphoric ester hydrolase activity phosphodiesterase I activity phosphoric diester hydrolase activity exonuclease activity double-stranded DNA 3'-5' DNA exonuclease activity DNA exonuclease activity 3'-5' exonuclease activity double-stranded DNA exodeoxyribonuclease activity DNA exonuclease activity, producing 5'-phosphomonoesters exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 3'-5'-DNA exonuclease activity DNA binding binding organic cyclic compound binding nucleic acid binding damaged DNA binding DNA-(abasic site) binding cation binding ion binding metal ion binding small molecule binding oxidoreductase activity uracil DNA N-glycosylase activity hydrolase activity, acting on glycosyl bonds deaminated base DNA N-glycosylase activity DNA N-glycosylase activity hydrolase activity, hydrolyzing N-glycosyl compounds transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding sequence-specific DNA binding double-stranded telomeric DNA binding double-stranded DNA binding telomeric DNA binding transcription corepressor activity phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands protein-containing complex binding chromatin binding chromatin DNA binding RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA RNA-DNA hybrid ribonuclease activity RNA nuclease activity RNA endonuclease activity	catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus telomere maintenance in response to DNA damage response to stimulus telomere organization cellular component organization base-excision repair cellular response to stress response to stress cellular component organization or biogenesis DNA repair chromosome organization telomere maintenance organelle organization DNA damage response cellular process telomere maintenance via base-excision repair regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation apoptotic process regulation of programmed cell death cell death programmed cell death cell redox homeostasis cellular homeostasis homeostatic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression regulation of biological quality RNA catabolic process mRNA catabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process regulation of mRNA catabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of catabolic process mRNA metabolic process regulation of mRNA stability negative regulation of biosynthetic process regulation of RNA stability regulation of mRNA metabolic process DNA modification DNA demethylation DNA dealkylation macromolecule modification demethylation DNA recombination base-excision repair, gap-filling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm perinuclear region of cytoplasm intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle mitochondrion nucleolus centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton ribosome endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth B], F [auth A]	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily
E [auth B], F [auth A]	IPR005135	Endonuclease/exonuclease/phosphatase	Domain
E [auth B], F [auth A]	IPR020847	AP endonuclease 1, binding site	Binding Site
E [auth B], F [auth A]	IPR020848	AP endonuclease 1, conserved site	Conserved Site
E [auth B], F [auth A]	IPR004808	AP endonuclease 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth B], F [auth A]	Pharos: P27695	melanoma lung adenocarcinoma heart disease visual epilepsy prostate cancer Generalized Absence Seizures Takayasu arteritis hereditary diffuse gastric adenocarcinoma ovarian cancer cutaneous melanoma gastric cancer inherited disease susceptibility large cell medulloblastoma lung cancer medulloblastoma melanoma lung adenocarcinoma heart disease visual epilepsy prostate cancer Generalized Absence Seizures Takayasu arteritis hereditary diffuse gastric adenocarcinoma ovarian cancer cutaneous melanoma gastric cancer inherited disease susceptibility large cell medulloblastoma lung cancer medulloblastoma atypical teratoid rhabdoid tumor brain injury plasma cell myeloma gastric neoplasm glioblastoma hepatocellular carcinoma lymphoplasmacytic lymphoma astrocytic tumor oligodendroglioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.