Annotations: 1DDG

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ddga1	All beta proteins	Reductase/isomerase/elongation factor common domain	Riboflavin synthase domain-like	NADPH-cytochrome p450 reductase FAD-binding domain-like	Sulfite reductase flavoprotein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1ddga2	Alpha and beta proteins (a/b)	Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	NADPH-cytochrome p450 reductase-like	Sulfite reductase flavoprotein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1ddgb1	All beta proteins	Reductase/isomerase/elongation factor common domain	Riboflavin synthase domain-like	NADPH-cytochrome p450 reductase FAD-binding domain-like	Sulfite reductase flavoprotein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1ddgb2	Alpha and beta proteins (a/b)	Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	NADPH-cytochrome p450 reductase-like	Sulfite reductase flavoprotein	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NADPH-cytochrome p450 reductase-like	8031819	4003798	SCOP2 (2022-06-29)
A	SCOP2 Family	NADPH-cytochrome p450 reductase FAD-binding domain-like	8029689	4002074	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ferredoxin reductase-like C-terminal NADP-linked domain	8044197	3001461	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Riboflavin synthase domain-like	8042068	3001812	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Ferredoxin reductase-like C-terminal NADP-linked domain	8044197	3001461	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Riboflavin synthase domain-like	8042068	3001812	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00667	e1ddgA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00667	ECOD (1.6)
A	F_UNCLASSIFIED	e1ddgA4	A: alpha bundles	X: NADPH-cytochrome p450 reductase helical insertion domain (From Topology)	H: NADPH-cytochrome p450 reductase helical insertion domain (From Topology)	T: NADPH-cytochrome p450 reductase helical insertion domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00175	e1ddgA2	A: a/b three-layered sandwiches	X: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	H: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	T: Ferredoxin reductase-like, C-terminal NADP-linked domain	F: PF00175	ECOD (1.6)
B	PF00667	e1ddgB4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00667	ECOD (1.6)
B	F_UNCLASSIFIED	e1ddgB3	A: alpha bundles	X: NADPH-cytochrome p450 reductase helical insertion domain (From Topology)	H: NADPH-cytochrome p450 reductase helical insertion domain (From Topology)	T: NADPH-cytochrome p450 reductase helical insertion domain	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00175	e1ddgB2	A: a/b three-layered sandwiches	X: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	H: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	T: Ferredoxin reductase-like, C-terminal NADP-linked domain	F: PF00175	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
A	1.20.990.10	Mainly Alpha	Up-down Bundle	NADPH-cytochrome p450 Reductase	Chain A, domain 3	CATH (4.3.0)
A	3.40.50.80	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module	CATH (4.3.0)
B	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
B	1.20.990.10	Mainly Alpha	Up-down Bundle	NADPH-cytochrome p450 Reductase	Chain A, domain 3	CATH (4.3.0)
B	3.40.50.80	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00667	FAD binding domain (FAD_binding_1)	FAD binding domain	This domain is found in sulfite reductase, NADPH cytochrome P450 reductase, Nitric oxide synthase and methionine synthase reductase.	Domain
A, B	PF00175	Oxidoreductase NAD-binding domain (NAD_binding_1)	Oxidoreductase NAD-binding domain	Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT	oxidoreductase activity catalytic activity NADP+ binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity catalytic activity NADP+ binding binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADP binding small molecule binding oxidoreductase activity, acting on a sulfur group of donors sulfite reductase (NADPH) activity sulfite reductase activity oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor FMN binding carbohydrate derivative binding ribonucleotide binding flavin adenine dinucleotide binding riboflavin reductase (NADPH) activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors	sulfur compound biosynthetic process biosynthetic process cellular biosynthetic process cellular metabolic process sulfur compound metabolic process metabolic process cellular process hydrogen sulfide biosynthetic process hydrogen sulfide metabolic process serine family amino acid metabolic process oxoacid metabolic process sulfur amino acid metabolic process organonitrogen compound biosynthetic process amino acid metabolic process sulfur compound biosynthetic process biosynthetic process cellular biosynthetic process cellular metabolic process sulfur compound metabolic process metabolic process cellular process hydrogen sulfide biosynthetic process hydrogen sulfide metabolic process serine family amino acid metabolic process oxoacid metabolic process sulfur amino acid metabolic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process cysteine biosynthetic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process organonitrogen compound metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process cysteine metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process proteinogenic amino acid biosynthetic process serine family amino acid biosynthetic process sulfur amino acid biosynthetic process alpha-amino acid biosynthetic process sulfate assimilation	protein-containing complex catalytic complex sulfite reductase complex (NADPH) intracellular protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase	Domain
A, B	IPR001433	Oxidoreductase FAD/NAD(P)-binding	Domain
A, B	IPR010199	Sulphite reductase [NADPH] flavoprotein, alpha chain	Family
A, B	IPR003097	Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding	Domain
A, B	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily	Homologous Superfamily
A, B	IPR008254	Flavodoxin/nitric oxide synthase	Domain
A, B	IPR029758	Sulphite reductase [NADPH] flavoprotein, alpha chain, Proteobacteria	Family
A, B	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Homologous Superfamily
A, B	IPR017938	Riboflavin synthase-like beta-barrel	Homologous Superfamily
A, B	IPR001094	Flavodoxin-like	Domain
A, B	IPR017927	FAD-binding domain, ferredoxin reductase-type	Domain
A, B	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.