Annotations: 1DDF

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ddfa1	All alpha proteins	DEATH domain	DEATH domain	DEATH domain, DD	Fas	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ddfa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1ddfa3	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DEATH domain DD	8025591	4000378	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8037970	3000069	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00531	e1ddfA1	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: PF00531	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.533.10	Mainly Alpha	Orthogonal Bundle	Death Domain, Fas	Death Domain, Fas	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FAS	molecular transducer activity signaling receptor activity protein binding binding kinase binding enzyme binding transmembrane signaling receptor activity tumor necrosis factor receptor activity death receptor activity calmodulin binding identical protein binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway cell communication positive regulation of response to stimulus signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process biological regulation cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication apoptotic process programmed cell death positive regulation of signaling regulation of apoptotic signaling pathway immune response immune system process neuron apoptotic process motor neuron apoptotic process negative regulation of programmed cell death negative regulation of biological process negative regulation of apoptotic process negative regulation of cellular process cellular response to oxygen levels cellular response to hyperoxia cellular response to chemical stress cellular response to increased oxygen levels response to hyperoxia cellular response to chemical stimulus cellular response to stress response to stress response to chemical response to oxygen levels response to abiotic stimulus response to increased oxygen levels cell surface receptor signaling pathway extrinsic apoptotic signaling pathway multicellular organismal process homeostatic process leukocyte apoptotic process lymphocyte apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis activation-induced cell death of T cells homeostasis of number of cells T cell apoptotic process lymphocyte homeostasis regulation of cellular response to stress intracellular signal transduction stress-activated MAPK cascade regulation of intracellular signal transduction regulation of response to stress intracellular signaling cassette regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade MAPK cascade necroptotic process programmed necrotic cell death necroptotic signaling pathway signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process organic substance metabolic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway macromolecule metabolic process regulation of metabolic process response to mechanical stimulus response to external stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of cellular metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation Fas signaling pathway	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane microdomain membrane raft protein-containing complex plasma membrane protein complex death-inducing signaling complex membrane protein complex CD95 death-inducing signaling complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR033998	Fas receptor, death domain	Domain
A	IPR033999	Fas receptor, N-terminal	Domain
A	IPR008063	Fas receptor	Family
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR000488	Death domain	Domain
A	IPR001368	TNFR/NGFR cysteine-rich region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P25445	autoimmune lymphoproliferative syndrome cardiomyopathy diffuse large B-cell lymphoma hematologic disease myasthenia gravis dilated cardiomyopathy acute myeloid leukemia non-alcoholic fatty liver disease acute liver failure Plasmodium falciparum malaria juvenile idiopathic arthritis proteinuria Necrosis type 2 diabetes mellitus acute lung injury autoimmune lymphoproliferative syndrome cardiomyopathy diffuse large B-cell lymphoma hematologic disease myasthenia gravis dilated cardiomyopathy acute myeloid leukemia non-alcoholic fatty liver disease acute liver failure Plasmodium falciparum malaria juvenile idiopathic arthritis proteinuria Necrosis type 2 diabetes mellitus acute lung injury hypersplenism autoimmune lymphoproliferative syndrome type 1 B-cell chronic lymphocytic leukemia nephritis urinary bladder cancer Vogt-Koyanagi-Harada disease primary cutaneous T-cell non-Hodgkin lymphoma autoimmune disease Behcet disease maturity-onset diabetes of the young nasopharyngeal carcinoma dilated cardiomyopathy 1A Gaucher disease urinary bladder neoplasm granulomatous slack skin disease pancreatic ductal adenocarcinoma hydrolethalus syndrome lung cancer schizophrenia autoimmune lymphoproliferative syndrome type 2B squamous cell carcinoma malignant ependymoma breast cancer medulloblastoma non-Hodgkin lymphoma glioblastoma oligoarticular juvenile idiopathic arthritis pilocytic astrocytoma atypical teratoid rhabdoid tumor large cell medulloblastoma psoriasis lung carcinoma Sjogren syndrome malignant glioma cancer malignant pancreatic neoplasm gastric carcinoma non-small cell lung carcinoma glomerulonephritis ovarian cancer hematopoietic and lymphoid system neoplasm pituitary cancer interstitial cystitis lung benign neoplasm rheumatoid factor-negative juvenile idiopathic arthritis malignant colon neoplasm subependymal giant cell astrocytoma malignant mesothelioma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.