Annotations: 1D7K

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1d7kb1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	Alanine racemase C-terminal domain-like	Eukaryotic ODC-like	Eukaryotic ornithine decarboxylase (ODC)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1d7kb2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	PLP-binding barrel	Alanine racemase-like, N-terminal domain	Eukaryotic ornithine decarboxylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1d7ka1	All beta proteins	Domain of alpha and beta subunits of F1 ATP synthase-like	Alanine racemase C-terminal domain-like	Eukaryotic ODC-like	Eukaryotic ornithine decarboxylase (ODC)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1d7ka2	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	PLP-binding barrel	Alanine racemase-like, N-terminal domain	Eukaryotic ornithine decarboxylase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Alanine racemase C-terminal domain-like	8042328	3001044	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PLP-binding barrel	8043281	3000273	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Alanine racemase C-terminal domain-like	8042328	3001044	SCOP2B (2022-06-29)
A	SCOP2 Family	Alanine racemase-like N-terminal domain	8030902	4003111	SCOP2 (2022-06-29)
A	SCOP2 Family	Eukaryotic ODC-like	8029949	4003520	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PLP-binding barrel	8043281	3000273	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Alanine racemase C-terminal domain-like	8042328	3001044	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00278	e1d7kB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00278	ECOD (1.6)
B	PF02784	e1d7kB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02784	ECOD (1.6)
A	PF00278	e1d7kA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF00278	ECOD (1.6)
A	PF02784	e1d7kA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PF02784	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.37.10	Mainly Beta	Beta Barrel	Lyase, Ornithine Decarboxylase	Chain A, domain 1	CATH (4.3.0)
B	3.20.20.10	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Alanine racemase	CATH (4.3.0)
A	2.40.37.10	Mainly Beta	Beta Barrel	Lyase, Ornithine Decarboxylase	Chain A, domain 1	CATH (4.3.0)
A	3.20.20.10	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Alanine racemase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02784	Pyridoxal-dependent decarboxylase, pyridoxal binding domain (Orn_Arg_deC_N)	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.	Domain
A, B	PF00278	Pyridoxal-dependent decarboxylase, C-terminal sheet domain (Orn_DAP_Arg_deC)	Pyridoxal-dependent decarboxylase, C-terminal sheet domain	These pyridoxal-dependent decarboxylases act on ornithine, lysine, arginine and related substrates.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	HUMAN ORNITHINE DECARBOXYLASE	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity ornithine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process amine metabolic process organonitrogen compound metabolic process organic substance metabolic process metabolic process polyamine metabolic process regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process amine metabolic process organonitrogen compound metabolic process organic substance metabolic process metabolic process polyamine metabolic process biogenic amine metabolic process organonitrogen compound catabolic process catabolic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process macromolecule catabolic process regulation of primary metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development kidney development renal system development system development ornithine metabolic process oxoacid metabolic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process non-proteinogenic amino acid metabolic process biogenic amine biosynthetic process putrescine biosynthetic process from ornithine organic substance biosynthetic process putrescine metabolic process small molecule metabolic process cellular metabolic process carboxylic acid metabolic process putrescine biosynthetic process biosynthetic process amine biosynthetic process polyamine biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002433	Ornithine decarboxylase	Family
A, B	IPR029066	PLP-binding barrel	Homologous Superfamily
A, B	IPR022644	Orn/DAP/Arg decarboxylase 2, N-terminal	Domain
A, B	IPR022653	Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site	Binding Site
A, B	IPR022643	Orn/DAP/Arg decarboxylase 2, C-terminal	Domain
A, B	IPR009006	Alanine racemase/group IV decarboxylase, C-terminal	Homologous Superfamily
A, B	IPR000183	Ornithine/DAP/Arg decarboxylase	Family
A, B	IPR022657	Orn/DAP/Arg decarboxylase 2, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P11926	papilloma malignant colon neoplasm colorectal cancer HIV infectious disease skin cancer squamous papilloma skin neoplasm lung cancer malignant glioma oligodendroglioma plasma cell myeloma astrocytic tumor sinusitis benign colon neoplasm spina bifida papilloma malignant colon neoplasm colorectal cancer HIV infectious disease skin cancer squamous papilloma skin neoplasm lung cancer malignant glioma oligodendroglioma plasma cell myeloma astrocytic tumor sinusitis benign colon neoplasm spina bifida colorectal carcinoma dermatomyositis Female Facial Hirsutism invasive ductal breast carcinoma medulloblastoma ovarian cancer papillomatosis primitive neuroectodermal tumor atypical teratoid rhabdoid tumor colonic neoplasm diabetes mellitus glioblastoma human African trypanosomiasis large cell medulloblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma pituitary cancer psoriasis Barrett esophagus ulcerative colitis cutaneous lupus erythematosus esophageal adenocarcinoma hypotrichosis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	LLP	Parent Component: LYS RESID: AA0119 PSI-MOD : N6-pyridoxal phosphate-L-lysine MOD:00128

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.