1CQT

CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1cqta1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Homeodomain	Oct-1 POU Homeodomain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth A]	d1cqta2	All alpha proteins	lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	POU-specific domain	Oct-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d1cqtb1	All alpha proteins	DNA/RNA-binding 3-helical bundle	Homeodomain-like	Homeodomain	Oct-1 POU Homeodomain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth B]	d1cqtb2	All alpha proteins	lambda repressor-like DNA-binding domains	lambda repressor-like DNA-binding domains	POU-specific domain	Oct-1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2B Superfamily	Homeodomain-like	8017635	3000001	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	lambda C1 repressor DNA-binding domain-like	8017633	3000119	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	lambda C1 repressor DNA-binding domain-like	8017633	3000119	SCOP2B (2022-06-29)
F [auth B]	SCOP2B Superfamily	Homeodomain-like	8017635	3000001	SCOP2B (2022-06-29)
G [auth I]	SCOP2 Family	OCA-B N-terminal region-like	8044672	4004072	SCOP2 (2022-06-29)
G [auth I]	SCOP2 Superfamily	OCA-B N-terminal region-like	8051970	3002077	SCOP2 (2022-06-29)
H [auth J]	SCOP2B Superfamily	OCA-B N-terminal region-like	8051970	3002077	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	PF00046	e1cqtA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)
E [auth A]	PF00157	e1cqtA2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00157	ECOD (1.6)
F [auth B]	PF00046	e1cqtB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00046	ECOD (1.6)
F [auth B]	PF00157	e1cqtB2	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: PF00157	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
E [auth A]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)
F [auth B]	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
F [auth B]	1.10.10.60	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Homeodomain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B]	PF00046	Homeodomain (Homeodomain)	Homeodomain	-	Domain
E [auth A], F [auth B]	PF00157	Pou domain - N-terminal to homeobox domain (Pou)	Pou domain - N-terminal to homeobox domain	-	Domain
G [auth I], H [auth J]	PF09310	POU domain, class 2, associating factor 1 (PD-C2-AF1)	POU domain, class 2, associating factor 1	Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germi ...	Members of this family are transcriptional coactivators that specifically associate with either OCT1 or OCT2, through recognition of their POU domains. They are essential for the response of B-cells to antigens and required for the formation of germinal centres [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth M], C [auth O]	DNA (5'-D(TPGPTPAPTPGPCPAPAPAPTPAPAPGP*G)-3')	-	-	-
B [auth N], D [auth P]	DNA (5'-D(APCPCPTPTPAPTPTPTPGPCPAPTPAP*C)-3')	-	-	-
E [auth A], F [auth B]	POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1	DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process miRNA transcription positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle endoplasmic reticulum cytoplasm endomembrane system
G [auth I], H [auth J]	POU DOMAIN, CLASS 2, ASSOCIATING FACTOR 1	DNA binding binding organic cyclic compound binding nucleic acid binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity POU domain binding protein binding protein domain specific binding	multicellular organismal process response to stimulus cellular developmental process germinal center B cell differentiation cell development mononuclear cell differentiation mature B cell differentiation B cell activation involved in immune response lymphocyte activation cell activation involved in immune response lymphocyte differentiation leukocyte activation B cell differentiation cell differentiation leukocyte activation involved in immune response multicellular organismal process response to stimulus cellular developmental process germinal center B cell differentiation cell development mononuclear cell differentiation mature B cell differentiation B cell activation involved in immune response lymphocyte activation cell activation involved in immune response lymphocyte differentiation leukocyte activation B cell differentiation cell differentiation leukocyte activation involved in immune response anatomical structure development lymphocyte activation involved in immune response developmental process mature B cell differentiation involved in immune response immune response hemopoiesis B cell activation cell activation immune effector process immune system process cellular process leukocyte differentiation humoral immune response regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B]	IPR001356	Homeobox domain	Domain
E [auth A], F [auth B]	IPR000327	POU-specific domain	Domain
E [auth A], F [auth B]	IPR013847	POU domain	Domain
E [auth A], F [auth B]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
E [auth A], F [auth B]	IPR017970	Homeobox, conserved site	Conserved Site
E [auth A], F [auth B]	IPR000972	Octamer-binding transcription factor	Family
E [auth A], F [auth B]	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily
E [auth A], F [auth B]	IPR045703	POU domain, class 2, transcription factor 1, C-terminal	Domain
G [auth I], H [auth J]	IPR047571	OCA domain	Domain
G [auth I], H [auth J]	IPR015389	POU, class 2, associating factor 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth A], F [auth B]	Pharos: P14859	allergic rhinitis Hashimoto thyroiditis Malignant neoplasm of breast primitive neuroectodermal tumor asthma hypothyroidism medulloblastoma systemic sclerosis astrocytic tumor malignant mesothelioma osteosarcoma
G [auth I], H [auth J]	Pharos: Q16633	primary biliary cholangitis malignant glioma nephrolithiasis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis ulcerative colitis Barrett esophagus cancer colorectal adenoma cystic fibrosis Hodgkins lymphoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm non-small cell lung carcinoma primary biliary cholangitis malignant glioma nephrolithiasis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis ulcerative colitis Barrett esophagus cancer colorectal adenoma cystic fibrosis Hodgkins lymphoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm non-small cell lung carcinoma periodontitis sinusitis breast cancer celiac disease colorectal cancer exocrine pancreatic carcinoma interstitial cystitis lung cancer malignant ependymoma nasopharyngeal carcinoma osteosarcoma Sjogren syndrome Bruton-type agammaglobulinemia chronic obstructive pulmonary disease cutaneous lupus erythematosus head and neck cancer large cell medulloblastoma lung carcinoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.