Annotations: 1C9I

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1c9ia1	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin heavy-chain linker domain	Clathrin heavy-chain linker domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1c9ia2	All beta proteins	7-bladed beta-propeller	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1c9ib1	All alpha proteins	alpha-alpha superhelix	ARM repeat	Clathrin heavy-chain linker domain	Clathrin heavy-chain linker domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B	d1c9ib2	All beta proteins	7-bladed beta-propeller	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Clathrin heavy-chain terminal domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01394	e1c9iA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
A	PF09268	e1c9iA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268	ECOD (1.6)
B	PF01394	e1c9iB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF01394	ECOD (1.6)
B	PF09268	e1c9iB2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF09268	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.110	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.110	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF09268	Clathrin, heavy-chain linker (Clathrin-link)	Clathrin, heavy-chain linker	-	Repeat
A, B	PF13838	Clathrin-H-link (Clathrin_H_link)	Clathrin-H-link	-	Repeat
A, B	PF01394	Clathrin propeller repeat (Clathrin_propel)	Clathrin propeller repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	CLATHRIN	clathrin binding protein binding binding clathrin light chain binding RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding ankyrin binding heat shock protein binding ubiquitin-specific protease binding enzyme binding protease binding clathrin binding protein binding binding clathrin light chain binding RNA binding double-stranded RNA binding organic cyclic compound binding nucleic acid binding cytoskeletal protein binding ankyrin binding heat shock protein binding ubiquitin-specific protease binding enzyme binding protease binding protein serine/threonine kinase binding kinase binding protein kinase binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding peptide binding structural molecule activity disordered domain specific binding protein domain specific binding	localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly protein-containing complex organization protein-containing complex disassembly vesicle uncoating cellular component organization cellular component organization or biogenesis protein depolymerization cellular localization intracellular transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi establishment of localization in cell protein localization establishment of protein localization nitrogen compound transport organic substance transport iron ion transport metal ion transport protein transport cellular macromolecule localization macromolecule localization transferrin transport transition metal ion transport monoatomic ion transport monoatomic cation transport cell cycle mitotic cell cycle synaptic vesicle endocytosis synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling regulation of localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane clathrin-dependent endocytosis regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization intracellular protein transport clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex assembly non-membrane-bounded organelle assembly mitotic sister chromatid segregation chromosome segregation mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle assembly nuclear division nuclear chromosome segregation multicellular organismal process amyloid-beta clearance amyloid-beta clearance by transcytosis transcytosis organonitrogen compound biosynthetic process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process negative regulation of metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process hyaluronan biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process mucopolysaccharide metabolic process cellular biosynthetic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process organic substance metabolic process hyaluronan metabolic process polysaccharide metabolic process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process organonitrogen compound metabolic process polysaccharide biosynthetic process regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process Golgi organization endomembrane system organization	cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity clathrin-coated pit endomembrane system presynaptic endocytic zone synapse presynaptic membrane synaptic membrane presynapse presynaptic endocytic zone membrane cell periphery sarcolemma plasma membrane membrane T-tubule cellular anatomical entity clathrin-coated pit endomembrane system presynaptic endocytic zone synapse presynaptic membrane synaptic membrane presynapse presynaptic endocytic zone membrane cell junction plasma membrane region membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cytosol cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane coat protein-containing complex membrane protein complex coated membrane polymeric cytoskeletal fiber mitotic spindle spindle microtubule mitotic spindle microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex plasma membrane protein complex clathrin coat clathrin coat of coated pit pigment granule melanosome axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus extrinsic component of synaptic vesicle membrane transport vesicle membrane extrinsic component of organelle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane secretory vesicle extrinsic component of membrane exocytic vesicle nucleus nuclear protein-containing complex Myb complex clathrin complex photoreceptor ribbon synapse ribbon synapse vesicle coat clathrin coat of trans-Golgi network vesicle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle clathrin vesicle coat Golgi-associated vesicle Golgi apparatus Golgi-associated vesicle membrane
C, D	B-ADAPTIN 3	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016341	Clathrin, heavy chain	Family
A, B	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
A, B	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, B	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
A, B	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.