Annotations: 1C25

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1c25a_	Alpha and beta proteins (a/b)	Rhodanese/Cell cycle control phosphatase	Rhodanese/Cell cycle control phosphatase	Cell cycle control phosphatase, catalytic domain	CDC25a	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	CDC25 phosphatase catalytic domain-like	8031977	4000447	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Rhodanese/Cell cycle control phosphatase	8044355	3000320	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Rhodanese	e1c25A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Rhodanese/Cell cycle control phosphatase	F: Rhodanese	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.250.10	Alpha Beta	3-Layer(aba) Sandwich	Oxidized Rhodanese	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00581	Rhodanese-like domain (Rhodanese)	Rhodanese-like domain	Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CDC25A	protein binding binding kinase binding enzyme binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein tyrosine phosphatase activity protein-folding chaperone binding	cellular response to stimulus response to light stimulus response to stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular process cellular response to abiotic stimulus cellular response to UV regulation of cell cycle phase transition regulation of cellular process cellular response to stimulus response to light stimulus response to stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular process cellular response to abiotic stimulus cellular response to UV regulation of cell cycle phase transition regulation of cellular process sexual reproduction regulation of reproductive process reproductive process positive regulation of biological process cell cycle phase transition meiotic cell cycle process positive regulation of cell cycle process G2/MI transition of meiotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of reproductive process cell cycle G2/M phase transition regulation of biological process regulation of meiotic cell cycle regulation of cell cycle process positive regulation of meiotic cell cycle phase transition positive regulation of G2/MI transition of meiotic cell cycle regulation of meiotic cell cycle phase transition meiotic cell cycle biological regulation positive regulation of meiotic cell cycle regulation of cell cycle G2/M phase transition positive regulation of cell cycle G2/M phase transition positive regulation of cell cycle meiotic cell cycle phase transition meiosis I cell cycle process positive regulation of cell cycle phase transition regulation of G2/MI transition of meiotic cell cycle mitotic cell cycle process G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell division cell population proliferation positive regulation of DNA replication regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process organic substance metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication positive regulation of DNA metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA replication regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of cyclin-dependent protein kinase activity regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process regulation of protein kinase activity regulation of molecular function regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process G2/M transition of mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of mitotic cell cycle positive regulation of G2/M transition of mitotic cell cycle regulation of G2/M transition of mitotic cell cycle regulation of mitotic cell cycle phase transition	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001763	Rhodanese-like domain	Domain
A	IPR036873	Rhodanese-like domain superfamily	Homologous Superfamily
A	IPR000751	M-phase inducer phosphatase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P30304	adrenal cortex carcinoma ductal breast carcinoma in situ heart disease malignant colon neoplasm medulloblastoma ovarian cancer psoriasis atypical teratoid rhabdoid tumor facioscapulohumeral muscular dystrophy large cell medulloblastoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma breast cancer glioblastoma adrenal cortex carcinoma ductal breast carcinoma in situ heart disease malignant colon neoplasm medulloblastoma ovarian cancer psoriasis atypical teratoid rhabdoid tumor facioscapulohumeral muscular dystrophy large cell medulloblastoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma breast cancer glioblastoma lung cancer malignant mesothelioma osteosarcoma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.