Annotations: 1BV8

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bv8a_	All beta proteins	Immunoglobulin-like beta-sandwich	Macroglobulin	Alpha-macroglobulin receptor domain	alpha-2-macroglobulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	alpha-macroglobulin receptor domain	8027833	4002046	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha-macroglobulin receptor domain	8040212	3000742	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	A2M_recep	e1bv8A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: A2M_recep	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.690	Mainly Beta	Sandwich	Immunoglobulin-like	Alpha-macroglobulin, receptor-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF07677	A-macroglobulin receptor binding domain (A2M_recep)	A-macroglobulin receptor binding domain	This family includes the receptor binding domain region of the alpha-2-macroglobulin family.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ALPHA-2-MACROGLOBULIN	protein binding binding signaling receptor binding neurotrophin binding brain-derived neurotrophic factor binding growth factor binding enzyme binding protease binding interleukin-1 binding cytokine binding nerve growth factor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity protein binding binding signaling receptor binding neurotrophin binding brain-derived neurotrophic factor binding growth factor binding enzyme binding protease binding interleukin-1 binding cytokine binding nerve growth factor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity chemokine binding C-X-C chemokine binding interleukin-8 binding serine-type endopeptidase inhibitor activity tumor necrosis factor binding calcium-dependent protein binding identical protein binding	response to stimulus defense response immune response response to stress immune system process inflammatory response acute inflammatory response to antigenic stimulus acute inflammatory response inflammatory response to antigenic stimulus regulation of humoral immune response regulation of immune effector process negative regulation of biological process response to biotic stimulus complement activation response to stimulus defense response immune response response to stress immune system process inflammatory response acute inflammatory response to antigenic stimulus acute inflammatory response inflammatory response to antigenic stimulus regulation of humoral immune response regulation of immune effector process negative regulation of biological process response to biotic stimulus complement activation positive regulation of immune response regulation of immune system process positive regulation of immune system process complement activation, lectin pathway regulation of biological process response to other organism negative regulation of immune response regulation of innate immune response negative regulation of immune effector process negative regulation of humoral immune response response to external stimulus immune effector process regulation of response to stimulus defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response regulation of complement activation activation of immune response regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus positive regulation of biological process negative regulation of complement activation positive regulation of response to stimulus regulation of response to stress innate immune response response to external biotic stimulus regulation of complement activation, lectin pathway negative regulation of response to stimulus biological regulation defense response to symbiont negative regulation of immune system process negative regulation of complement activation, lectin pathway negative regulation of innate immune response response to organic substance response to chemical response to oxygen-containing compound response to carbon dioxide response to corticosteroid response to lipid response to hormone response to steroid hormone response to endogenous stimulus response to glucocorticoid response to organic cyclic compound acute-phase response response to ketone response to prostaglandin response to alcohol response to prostaglandin E developmental process multicellular organism development multicellular organismal process anatomical structure development animal organ development embryonic organ development embryo development embryonic liver development response to nutrient levels response to nutrient stem cell differentiation cellular developmental process cell differentiation cellular process rhythmic process ovulation cycle process gonad development reproductive system development luteinization reproductive process female gonad development sex differentiation multicellular organismal reproductive process female sex differentiation development of primary female sexual characteristics developmental process involved in reproduction ovulation cycle development of primary sexual characteristics reproductive structure development system development	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix blood microparticle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen secretory granule secretory vesicle cytoplasm platelet alpha granule platelet alpha granule lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019742	Alpha-2-macroglobulin, conserved site	Conserved Site
A	IPR009048	Alpha-macroglobulin, receptor-binding	Domain
A	IPR041555	Macroglobulin domain MG3	Domain
A	IPR001599	Alpha-2-macroglobulin	Domain
A	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region	Conserved Site
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR041813	Alpha-2-macroglobulin, TED domain	Domain
A	IPR011625	Alpha-2-macroglobulin, bait region domain	Domain
A	IPR011626	Alpha-macroglobulin-like, TED domain	Domain
A	IPR010916	TonB box, conserved site	Conserved Site
A	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily	Homologous Superfamily
A	IPR002890	Macroglobulin domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
A	IPR040839	Macroglobulin domain MG4	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P01023	Alzheimer disease malignant colon neoplasm hepatocellular adenoma Wilson disease nephrotic syndrome Liver Cirrhosis, Experimental alpha-2-macroglobulin deficiency cirrhosis of liver glioblastoma ulcerative colitis hepatocellular carcinoma lung benign neoplasm lung disease Alzheimer disease type 1 benign colon neoplasm Alzheimer disease malignant colon neoplasm hepatocellular adenoma Wilson disease nephrotic syndrome Liver Cirrhosis, Experimental alpha-2-macroglobulin deficiency cirrhosis of liver glioblastoma ulcerative colitis hepatocellular carcinoma lung benign neoplasm lung disease Alzheimer disease type 1 benign colon neoplasm non-small cell lung carcinoma colonic neoplasm pancreatic ductal adenocarcinoma esophageal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia gastric carcinoma pterygium invasive ductal breast carcinoma lung cancer acute kidney failure malignant ependymoma astrocytic tumor breast cancer oligodendroglioma depressive disorder pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Gaucher disease subependymal giant cell astrocytoma lung adenocarcinoma lung carcinoma malignant glioma Becker muscular dystrophy ovarian cancer Duchenne muscular dystrophy pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.