1BT6

P11 (S100A10), LIGAND OF ANNEXIN II IN COMPLEX WITH ANNEXIN II N-TERMINUS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bt6a_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1bt6b_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8037283	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01023	e1bt6A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)
B	PF01023	e1bt6B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	ANNEXIN II	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding enzyme binding protease binding calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity cytoskeletal protein binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding calcium-dependent phospholipid binding virion binding modified amino acid binding phosphatidylserine binding enzyme regulator activity molecular function inhibitor activity phospholipase inhibitor activity phospholipase A2 inhibitor activity molecular function regulator activity enzyme inhibitor activity lipase inhibitor activity	multicellular organismal process connective tissue development developmental growth endochondral bone morphogenesis organ growth multicellular organism development skeletal system development growth plate cartilage development anatomical structure development endochondral bone growth animal organ morphogenesis bone development system development developmental process multicellular organismal process connective tissue development developmental growth endochondral bone morphogenesis organ growth multicellular organism development skeletal system development growth plate cartilage development anatomical structure development endochondral bone growth animal organ morphogenesis bone development system development developmental process growth animal organ development tissue development anatomical structure morphogenesis bone growth skeletal system morphogenesis cartilage development involved in endochondral bone morphogenesis bone morphogenesis cartilage development ossification bone mineralization biomineral tissue development regulation of cartilage development regulation of chondrocyte differentiation regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of chondrocyte differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of multicellular organismal process positive regulation of cellular process regulation of multicellular organismal development regulation of biological process biological regulation chondrocyte differentiation positive regulation of multicellular organismal process positive regulation of cartilage development cellular process regulation of protein maturation cellular biosynthetic process protein maturation regulation of primary metabolic process organic substance metabolic process regulation of proteolysis proteolysis organic substance biosynthetic process regulation of plasminogen activation protein metabolic process plasminogen activation zymogen activation regulation of biosynthetic process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis calcium ion homeostasis monoatomic cation homeostasis regulation of localization regulation of calcium ion transport positive regulation of calcium ion transport transport regulation of transport regulation of monoatomic ion transport establishment of localization calcium ion transport metal ion transport localization positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport heart development epithelium development endothelial cell differentiation endothelium development cardiac endothelial cell differentiation endocardium development epithelial cell differentiation cardiocyte differentiation circulatory system development endocardial cell differentiation transforming growth factor beta3 production cytokine production transforming growth factor beta production	membrane-bounded organelle organelle cellular anatomical entity vesicle basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane intracellular anatomical structure cytoplasm protein-containing complex membrane-bounded organelle organelle cellular anatomical entity vesicle basement membrane cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix plasma membrane membrane intracellular anatomical structure cytoplasm protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex extracellular region extracellular space intracellular organelle nucleus intracellular membrane-bounded organelle
A, B	S100A10	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding transmembrane transporter binding identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding	developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation cell development regulation of neurogenesis regulation of cell differentiation nervous system development regulation of cell development regulation of nervous system development multicellular organism development neurogenesis cell differentiation anatomical structure development regulation of multicellular organismal process cellular process system development regulation of protein maturation positive regulation of protein maturation positive regulation of macromolecule biosynthetic process positive regulation of protein processing protein maturation regulation of primary metabolic process positive regulation of metabolic process positive regulation of plasminogen activation regulation of proteolysis proteolysis organic substance biosynthetic process positive regulation of macromolecule metabolic process plasminogen activation zymogen activation cellular metabolic process regulation of protein metabolic process primary metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of proteolysis regulation of protein processing protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of plasminogen activation protein metabolic process positive regulation of cellular process regulation of biosynthetic process organonitrogen compound metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process regulation of localization transport positive regulation of secretion by cell positive regulation of exocytosis vesicle-mediated transport localization regulation of secretion by cell secretion by cell positive regulation of secretion regulation of transport secretion export from cell regulation of vesicle-mediated transport establishment of localization regulation of secretion positive regulation of transport exocytosis regulation of exocytosis positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity positive regulation of catalytic activity regulation of GTPase activity positive regulation of GTPase activity protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly regulation of cell-substrate junction organization cellular component organization or biogenesis focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly membrane organization vesicle budding from membrane vesicle organization organelle organization wound healing response to stimulus plasma membrane repair regulation of plasma membrane organization response to stress plasma membrane organization regulation of plasma membrane repair positive regulation of plasma membrane repair response to wounding endomembrane system organization membrane raft organization membrane biogenesis membrane raft assembly membrane assembly mRNA transcription by RNA polymerase II RNA metabolic process mRNA transcription nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II nucleobase-containing compound biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cytoskeleton organization actin filament organization positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix protein-containing complex AnxA2-p11 complex RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cell surface plasma membrane membrane cytoplasm plasma membrane protein complex membrane protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR002389	Annexin A2	Family
C, D	IPR001464	Annexin	Family
C, D	IPR018252	Annexin repeat, conserved site	Conserved Site
C, D	IPR037104	Annexin superfamily	Homologous Superfamily
C, D	IPR018502	Annexin repeat	Repeat
A, B	IPR028476	Protein S100-A10	Family
A, B	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P60903	acute myeloid leukemia medulloblastoma keloid Liver Cirrhosis, Experimental melanotic medulloblastoma adult medulloblastoma medullomyoblastoma with myogenic differentiation endogenous depression melancholia childhood medulloblastoma Duchenne muscular dystrophy gastric carcinoma malignant glioma adenoma atypical teratoid rhabdoid tumor acute myeloid leukemia medulloblastoma keloid Liver Cirrhosis, Experimental melanotic medulloblastoma adult medulloblastoma medullomyoblastoma with myogenic differentiation endogenous depression melancholia childhood medulloblastoma Duchenne muscular dystrophy gastric carcinoma malignant glioma adenoma atypical teratoid rhabdoid tumor breast cancer neurotic disorder cystic fibrosis pancreatic intraductal papillary-mucinous neoplasm depressive disorder pituitary cancer desmoplastic/nodular medulloblastoma Emery-Dreifuss muscular dystrophy glioblastoma large cell medulloblastoma lung cancer major depressive disorder malignant pancreatic neoplasm Becker muscular dystrophy breast fibroadenoma ovarian cancer Pick disease subependymal giant cell astrocytoma juvenile dermatomyositis limb-girdle muscular dystrophy lung carcinoma malignant ependymoma MALT lymphoma astrocytic tumor bipolar disorder pancreatic ductal adenocarcinoma pilocytic astrocytoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.