1BT3

CATECHOL OXIDASE FROM IPOMOEA BATATAS (SWEET POTATOES) IN THE NATIVE CU(II)-CU(II) STATE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Structure Motif: Primary M-CSA Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bt3a_	All alpha proteins	Di-copper centre-containing domain	Di-copper centre-containing domain	Catechol oxidase	Catechol oxidase	(Ipomoea batatas ) [TaxId: 4120 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Catechol oxidase	8025691	4001105	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Di-copper centre-containing domain	8038070	3000773	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00264,PF12142	e1bt3A1	A: alpha arrays	X: Di-copper centre-containing domain (From Topology)	H: Di-copper centre-containing domain (From Topology)	T: Di-copper centre-containing domain	F: PF00264,PF12142	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1280.10	Mainly Alpha	Orthogonal Bundle	di-copper center containing domain from catechol oxidase	Di-copper center containing domain from catechol oxidase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12142	Polyphenol oxidase middle domain (PPO1_DWL)	Polyphenol oxidase middle domain	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plas ...	This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plastids. There is a conserved DWL sequence motif which gives the family its name.	Domain
A	PF00264	Common central domain of tyrosinase (Tyrosinase)	Common central domain of tyrosinase	This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (CATECHOL OXIDASE)	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on diphenols and related substances as donors catechol oxidase activity catalytic activity cation binding transition metal ion binding copper ion binding ion binding binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular anatomical structure plastid cellular anatomical entity intracellular membrane-bounded organelle plastid thylakoid plastid thylakoid lumen intracellular organelle chloroplast thylakoid lumen organelle chloroplast thylakoid intracellular non-membrane-bounded organelle cytoplasm thylakoid lumen membrane-bounded organelle intracellular anatomical structure plastid cellular anatomical entity intracellular membrane-bounded organelle plastid thylakoid plastid thylakoid lumen intracellular organelle chloroplast thylakoid lumen organelle chloroplast thylakoid intracellular non-membrane-bounded organelle cytoplasm thylakoid lumen thylakoid non-membrane-bounded organelle chloroplast

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022739	Polyphenol oxidase, central domain	Domain
A	IPR008922	Di-copper centre-containing domain superfamily	Homologous Superfamily
A	IPR022740	Polyphenol oxidase, C-terminal	Domain
A	IPR002227	Tyrosinase copper-binding domain	Domain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

Chains	Enzyme Name	Description	Catalytic Residues
A	catechol oxidase M-CSA #125	Catechol oxidase is a type 3 copper protein that exclusively catalyses the oxidation of catechols (e.g. o-diphenols) to the corresponding o-quinones. The enzyme can also act on a variety of substituted catechols. Although a member of the same superfamily as tyrosinase, it is a different enzyme.	Defined by 7 residues: HIS:A-88HIS:A-109HIS:A-118HIS:A-240HIS:A-244PHE:A-261HIS:A-274 \| Explore in 3D: M-CSA Motif Definition Search M-CSA Motif EC: 1.10.3.1 (PDB Primary Data) Search M-CSA Motif + EC 1.10.3.1

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.