1BON

THREE-DIMENSIONAL STRUCTURE OF BOMBYXIN-II, AN INSULIN-RELATED BRAIN-SECRETORY PEPTIDE OF THE SILKMOTH BOMBYX MORI: COMPARISON WITH INSULIN AND RELAXIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1bon.1	Small proteins	Insulin-like	Insulin-like	Insulin-like	Bombyxin-II	domestic silkworm (Bombyx mori ) [TaxId: 7091 ],	SCOPe (2.08)
A	d1bon.1	Small proteins	Insulin-like	Insulin-like	Insulin-like	Bombyxin-II	domestic silkworm (Bombyx mori ) [TaxId: 7091 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain
A	PF00049	Insulin/IGF/Relaxin family (Insulin)	Insulin/IGF/Relaxin family	Superfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	BOMBYXIN-II,BOMBYXIN A-6	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity growth factor activity	-	extracellular region extracellular space cellular anatomical entity
A	BOMBYXIN-II,BOMBYXIN A-2	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity growth factor activity	-	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR022352	Insulin family	Family
B	IPR017097	Bombyxin	Family
B	IPR022353	Insulin, conserved site	Conserved Site
B	IPR030680	Bombyxin A	Family
B	IPR036438	Insulin-like superfamily	Homologous Superfamily
B	IPR040228	Insulin-related peptide, invertebrates	Family
B	IPR016179	Insulin-like	Domain
A	IPR022352	Insulin family	Family
A	IPR017097	Bombyxin	Family
A	IPR022353	Insulin, conserved site	Conserved Site
A	IPR030680	Bombyxin A	Family
A	IPR036438	Insulin-like superfamily	Homologous Superfamily
A	IPR016179	Insulin-like	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	PCA	Parent Component: GLN RESID: AA0031 PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.