1BNB

SOLUTION STRUCTURE OF BOVINE NEUTROPHIL BETA-DEFENSIN 12: THE PEPTIDE FOLD OF THE BETA-DEFENSINS IS IDENTICAL TO THAT OF THE CLASSICAL DEFENSINS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1bnba_	Small proteins	Defensin-like	Defensin-like	Defensin	Beta-defensin, BD	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Defensin	8026237	4003358	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Defensin-like	8038616	3000681	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00711	e1bnbA1	A: few secondary structure elements	X: Defensin-like	H: Defensin-related	T: Defensin-related	F: PF00711	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00711	Beta defensin (Defensin_beta)	Beta defensin	The beta defensins are antimicrobial peptides implicated in the resistance of epithelial surfaces to microbial colonisation [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BOVINE NEUTROPHIL BETA-DEFENSIN 12	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity chemoattractant activity signaling receptor activator activity CCR chemokine receptor binding cytokine receptor binding G protein-coupled receptor binding chemokine receptor binding CCR6 chemokine receptor binding	cell chemotaxis cellular response to stimulus chemotaxis response to stimulus response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cellular process cell motility locomotion biological process involved in interspecies interaction between organisms response to other organism cell chemotaxis cellular response to stimulus chemotaxis response to stimulus response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cellular process cell motility locomotion biological process involved in interspecies interaction between organisms response to other organism defense response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus	membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle specific granule membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle specific granule extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001855	Beta defensin type	Family
A	IPR006080	Beta/alpha-defensin, C-terminal	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.