Aralkylamine N-acetyltransferase (AANAT) catalyses the conversion of serotonin to N-acetylserotonin, the precursor to the circadian neurohormone melatonin, important in coordinating daily and seasonal rhythms with light levels in the surrounding environment. Levels of AANAT (and levels of melatonin) are controlled by the proteolysis of AANAT.
Defined by 5 residues: SER:A-70 [auth A-97]LEU:A-84 [auth A-111]HIS:A-95 [auth A-122]LEU:A-97 [auth A-124]TYR:A-141 [auth A-168]