1B3U

CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1b3ua_	All alpha proteins	alpha-alpha superhelix	ARM repeat	HEAT repeat	Constant regulatory domain of protein phosphatase 2a, pr65alpha	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1b3ub_	All alpha proteins	alpha-alpha superhelix	ARM repeat	HEAT repeat	Constant regulatory domain of protein phosphatase 2a, pr65alpha	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	HEAT repeat	8026189	4001283	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8038568	3000116	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02985,PF13646	e1b3uA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02985,PF13646	ECOD (1.6)
B	PF02985,PF13646	e1b3uB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02985,PF13646	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PROTEIN (PROTEIN PHOSPHATASE PP2A)	protein antigen binding protein binding binding antigen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity protein antigen binding protein binding binding antigen binding enzyme regulator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation meiotic spindle elongation meiotic chromosome segregation cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion response to organic substance response to stimulus response to chemical cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division regulation of cellular component organization negative regulation of biological process negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth negative regulation of cellular process RNA splicing cellular biosynthetic process RNA metabolic process gene expression macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process RNA processing negative regulation of signaling negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction MAPK cascade negative regulation of MAPK cascade negative regulation of cellular metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein negative regulation of receptor signaling pathway via JAK-STAT protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of protein phosphorylation regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of Wnt signaling pathway Wnt signaling pathway regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation ceramide metabolic process membrane lipid metabolic process sphingolipid metabolic process cellular lipid metabolic process amide metabolic process lipid metabolic process regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol intracellular non-membrane-bounded organelle chromosome, centromeric region chromosome chromosomal region non-membrane-bounded organelle somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR021133	HEAT, type 2	Repeat
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR000357	HEAT repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.