Annotations: 1AVO

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1avo.2	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1avo.3	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d1avo.4	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d1avo.5	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d1avo.6	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d1avo.7	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1avo.1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1avo.1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1avo.3	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1avo.4	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d1avo.5	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d1avo.6	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d1avo.7	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1avo.2	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	Proteasome activator reg(alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
E	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
G	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
I	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
K	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
M	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
A	1.20.5.120	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Proteasome activator pa28, N-terminal domain	CATH (4.3.0)
B	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
F	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
H	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
J	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
L	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
N	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)
D	1.20.120.180	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Proteasome activator pa28, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G, I A, C, E, G, I, K, M	PF02251	Proteasome activator pa28 alpha subunit (PA28_alpha)	Proteasome activator pa28 alpha subunit	-	Family
B, D, F, H, J B, D, F, H, J, L, N	PF02252	Proteasome activator pa28 beta subunit (PA28_beta)	Proteasome activator pa28 beta subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G, I A, C, E, G, I, K, M	11S REGULATOR	endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity	antigen processing and presentation immune system process antigen processing and presentation of exogenous antigen catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process antigen processing and presentation immune system process antigen processing and presentation of exogenous antigen catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process regulation of cell cycle phase transition regulation of cellular process regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process cellular process cell cycle regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome activator complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome activator complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen
B, D, F, H, J B, D, F, H, J, L, N	11S REGULATOR	endopeptidase activator activity enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity peptidase activator activity endopeptidase regulator activity	antigen processing and presentation immune system process antigen processing and presentation of exogenous antigen catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process antigen processing and presentation immune system process antigen processing and presentation of exogenous antigen catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process regulation of cell cycle phase transition regulation of cellular process regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process cellular process cell cycle regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition	protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome activator complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle protein-containing complex catalytic complex peptidase complex proteasome complex endopeptidase complex intracellular protein-containing complex proteasome accessory complex intracellular anatomical structure proteasome activator complex cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G, I A, C, E, G, I, K, M	IPR003186	Proteasome activator PA28, C-terminal domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR036252	Proteasome activator superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR036996	Proteasome activator PA28, N-terminal domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR003185	Proteasome activator PA28, N-terminal domain	Domain
A, C, E, G, I A, C, E, G, I, K, M	IPR036997	Proteasome activator PA28, C-terminal domain superfamily	Homologous Superfamily
A, C, E, G, I A, C, E, G, I, K, M	IPR009077	Proteasome activator PA28	Family
B, D, F, H, J B, D, F, H, J, L, N	IPR003186	Proteasome activator PA28, C-terminal domain	Domain
B, D, F, H, J B, D, F, H, J, L, N	IPR036252	Proteasome activator superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N	IPR036996	Proteasome activator PA28, N-terminal domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N	IPR003185	Proteasome activator PA28, N-terminal domain	Domain
B, D, F, H, J B, D, F, H, J, L, N	IPR036997	Proteasome activator PA28, C-terminal domain superfamily	Homologous Superfamily
B, D, F, H, J B, D, F, H, J, L, N	IPR009077	Proteasome activator PA28	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G, I A, C, E, G, I, K, M	Pharos: Q06323	esophageal squamous cell carcinoma carcinoma HIV infectious disease Mammary Neoplasms, Experimental sarcomatoid carcinoma ovarian cancer tuberculosis glioblastoma juvenile dermatomyositis mammary neoplasms, animal plasma cell myeloma undifferentiated carcinoma astrocytic tumor dermatomyositis lung cancer
B, D, F, H, J B, D, F, H, J, L, N	Pharos: Q06323	esophageal squamous cell carcinoma carcinoma HIV infectious disease Mammary Neoplasms, Experimental sarcomatoid carcinoma ovarian cancer tuberculosis glioblastoma juvenile dermatomyositis mammary neoplasms, animal plasma cell myeloma undifferentiated carcinoma astrocytic tumor dermatomyositis lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.