Annotations: 1AGR

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1agra1	All alpha proteins	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
A	d1agra2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Transducin (alpha subunit)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth D]	d1agrd1	All alpha proteins	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth D]	d1agrd2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Transducin (alpha subunit)	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
D [auth H]	d1agrh_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling 4, RGS4	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
C [auth E]	d1agre_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling 4, RGS4	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8019719	3002022	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Galpha insert domain-like	8056777	3000669	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8019719	3002022	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Galpha insert domain-like	8056777	3000669	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019719	3002022	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019719	3002022	SCOP2B (2022-06-29)
D [auth H]	SCOP2B Superfamily	Regulator of G-protein signaling RGS	8038096	3000835	SCOP2B (2022-06-29)
C [auth E]	SCOP2 Family	Regulator of G-protein signaling RGS	8025717	4001125	SCOP2 (2022-06-29)
C [auth E]	SCOP2 Superfamily	Regulator of G-protein signaling RGS	8038096	3000835	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00503	e1agrA1	A: alpha arrays	X: Transducin (alpha subunit), insertion domain (From Topology)	H: Transducin (alpha subunit), insertion domain (From Topology)	T: Transducin (alpha subunit), insertion domain	F: PF00503	ECOD (1.6)
A	PF00503	e1agrA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00503	ECOD (1.6)
B [auth D]	PF00503	e1agrD1	A: alpha arrays	X: Transducin (alpha subunit), insertion domain (From Topology)	H: Transducin (alpha subunit), insertion domain (From Topology)	T: Transducin (alpha subunit), insertion domain	F: PF00503	ECOD (1.6)
B [auth D]	PF00503	e1agrD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00503	ECOD (1.6)
D [auth H]	PF00615	e1agrH1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: PF00615	ECOD (1.6)
C [auth E]	PF00615	e1agrE1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: PF00615	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.10.400.10	Mainly Alpha	Orthogonal Bundle	GI Alpha 1, domain 2-like	GI Alpha 1, domain 2-like	CATH (4.3.0)
B [auth D]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B [auth D]	1.10.400.10	Mainly Alpha	Orthogonal Bundle	GI Alpha 1, domain 2-like	GI Alpha 1, domain 2-like	CATH (4.3.0)
D [auth H]	1.10.196.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 1	CATH (4.3.0)
D [auth H]	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)
C [auth E]	1.10.196.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 1	CATH (4.3.0)
C [auth E]	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D]	PF00503	G-protein alpha subunit (G-alpha)	G-protein alpha subunit	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...	G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].	Domain
C [auth E], D [auth H]	PF00615	Regulator of G protein signaling domain (RGS)	Regulator of G protein signaling domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D]	GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)	D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding GDP binding G protein-coupled serotonin receptor binding protein-containing complex binding G-protein beta/gamma-subunit complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell division cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell cycle regulation of cytoskeleton organization cellular process cell division cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell cycle regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization protein localization positive regulation of protein localization to cell periphery regulation of localization protein localization to cell periphery cellular localization regulation of protein localization positive regulation of biological process positive regulation of protein localization to cell cortex regulation of protein localization to cell periphery localization regulation of cellular localization regulation of protein localization to cell cortex cellular macromolecule localization macromolecule localization positive regulation of protein localization protein localization to cell cortex positive regulation of cellular process trans-synaptic signaling regulation of signaling negative regulation of signaling modulation of chemical synaptic transmission negative regulation of biological process cell-cell signaling negative regulation of synaptic transmission negative regulation of cell communication chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of cellular process regulation of cell communication regulation of signal transduction intracellular signal transduction cAMP-mediated signaling regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cAMP-mediated signaling response to organic substance response to ketone response to lipid response to alcohol cellular response to forskolin cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical response to forskolin cellular response to lipid cellular response to organic substance cellular response to ketone response to organic cyclic compound	midbody cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex midbody cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C [auth E], D [auth H]	RGS4	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein binding binding kinase binding enzyme binding protein kinase binding G-protein alpha-subunit binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate regulation of localization import into cell negative regulation of amino acid transport regulation of cellular process nitrogen compound transport negative regulation of amine transport carboxylic acid transmembrane transport transport glycine transport negative regulation of biological process regulation of glycine import across plasma membrane amino acid transmembrane transport negative regulation of transport L-amino acid transport negative regulation of glycine import across plasma membrane negative regulation of transmembrane transport localization negative regulation of cellular process regulation of amino acid transport regulation of amino acid transmembrane transport organic acid transmembrane transport organic anion transport glycine import across plasma membrane carboxylic acid transport regulation of transport organic substance transport import across plasma membrane neutral amino acid transport establishment of localization organic cation transport organic acid transport transmembrane transport amino acid transport amine transport regulation of amino acid import across plasma membrane regulation of transmembrane transport negative regulation of organic acid transport regulation of organic acid transport L-alpha-amino acid transmembrane transport cellular process regulation of amine transport amino acid import across plasma membrane cellular response to stimulus positive regulation of cell communication regulation of postsynaptic membrane potential positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission positive regulation of excitatory postsynaptic potential regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential signal transduction positive regulation of cellular process trans-synaptic signaling regulation of signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling regulation of growth negative regulation of muscle hypertrophy regulation of cardiac muscle tissue growth developmental growth negative regulation of muscle cell differentiation regulation of cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development multicellular organism development muscle adaptation negative regulation of growth cell differentiation regulation of organ growth regulation of heart growth anatomical structure development cardiac muscle tissue growth muscle tissue development cardiac cell development system development developmental process heart growth negative regulation of striated muscle cell differentiation negative regulation of cell growth striated muscle hypertrophy tissue development negative regulation of developmental growth regulation of muscle cell differentiation striated muscle cell differentiation negative regulation of multicellular organismal process regulation of cellular component organization regulation of developmental process cellular developmental process cardiac muscle cell development cell development negative regulation of cell growth involved in cardiac muscle cell development regulation of striated muscle cell differentiation negative regulation of cardiac muscle tissue growth organ growth cell growth striated muscle tissue development cellular component organization negative regulation of organ growth muscle cell development cardiac muscle hypertrophy negative regulation of cell differentiation cellular component organization or biogenesis muscle hypertrophy regulation of muscle adaptation heart development regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy negative regulation of developmental process growth animal organ development cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development regulation of cell growth regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of calcium ion transport regulation of monoatomic ion transport metal ion transport calcium ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport dorsal root ganglion development nervous system development ganglion development regulation of potassium ion transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport negative regulation of potassium ion transport inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport regulation of cytoskeleton organization regulation of actin filament organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization response to organic substance response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to nitrogen compound response to dopamine negative regulation of signaling dopamine receptor signaling pathway cellular response to dopamine response to monoamine negative regulation of cell communication regulation of dopamine receptor signaling pathway cellular response to endogenous stimulus response to catecholamine cellular response to catecholamine stimulus cellular response to organic substance response to organic cyclic compound negative regulation of response to stimulus response to organonitrogen compound response to endogenous stimulus negative regulation of dopamine receptor signaling pathway cellular response to organic cyclic compound response to nitrogen compound negative regulation of signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to monoamine stimulus response to amine response to amphetamine negative regulation of G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway response to cocaine response to alkaloid	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D]	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A, B [auth D]	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A, B [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B [auth D]	IPR001408	G-protein alpha subunit, group I	Family
C [auth E], D [auth H]	IPR016137	RGS domain	Domain
C [auth E], D [auth H]	IPR036305	RGS domain superfamily	Homologous Superfamily
C [auth E], D [auth H]	IPR044926	RGS, subdomain 2	Homologous Superfamily
C [auth E], D [auth H]	IPR034953	Regulator of G-protein signalling 4, RGS domain	Domain
C [auth E], D [auth H]	IPR024066	RGS, subdomain 1/3	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.