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THE 1.8 ANGSTROM CRYSTAL STRUCTURE OF THE DIMERIC PEROXISOMAL THIOLASE OF SACCHAROMYCES CEREVISIAE External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2B Superfamily Thiolase-like 8033429 3000122 SCOP2B (2022-06-29) A SCOP2B Superfamily Thiolase-like 8033428 3000122 SCOP2B (2022-06-29) B SCOP2 Family Thiolase-related 8021048 4000245 SCOP2 (2022-06-29) B SCOP2 Family Thiolase-related 8021049 4000245 SCOP2 (2022-06-29) B SCOP2 Superfamily Thiolase-like 8033428 3000122 SCOP2 (2022-06-29) B SCOP2 Superfamily Thiolase-like 8033429 3000122 SCOP2 (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF00108 e1afwA1 A: a/b three-layered sandwiches X: Thiolase-like (From Topology) H: Thiolase-like (From Topology) T: Thiolase-like F: PF00108 ECOD (1.6) A PF02803 e1afwA2 A: a/b three-layered sandwiches X: Thiolase-like (From Topology) H: Thiolase-like (From Topology) T: Thiolase-like F: PF02803 ECOD (1.6) B PF00108 e1afwB1 A: a/b three-layered sandwiches X: Thiolase-like (From Topology) H: Thiolase-like (From Topology) T: Thiolase-like F: PF00108 ECOD (1.6) B PF02803 e1afwB2 A: a/b three-layered sandwiches X: Thiolase-like (From Topology) H: Thiolase-like (From Topology) T: Thiolase-like F: PF02803 ECOD (1.6)
Chains Polymer Molecular Function Biological Process Cellular Component 3-KETOACETYL-COA THIOLASE
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage Chains Enzyme Name Description Catalytic Residues acetyl-CoA C-acyltransferase
M-CSA #77 Thiolases form a ubiquitous family of enzymes found in both prokaryotes and eukaryotes. Thiolases catalyse the reversible two step cleavage of acyl-CoA into CoA and acetyl-CoA. There are two classes of thiolases, I and II. This entry represents the Class II thiolases. Class II only acts upon acetoacetyl-CoA and its main function is to synthesise this compound in a Claisen condensation reaction important in several biosynthetic pathways.
 View MoreDefined by 4 residues: CYS:A-101 [auth A-125] HIS:A-351 [auth A-375] CYS:A-379 [auth A-403] GLY:A-381 [auth A-405]
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M-CSA Motif Definition