1A8Y

CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1a8ya1	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	Calsequestrin	Calsequestrin	(Oryctolagus cuniculus ) [TaxId: 9986 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Calsequestrin	8031991	4000467	SCOP2 (2022-06-29)
A	SCOP2 Family	Calsequestrin	8031992	4000467	SCOP2 (2022-06-29)
A	SCOP2 Family	Calsequestrin	8031993	4000467	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8044369	3000031	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8044370	3000031	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Thioredoxin-like	8044371	3000031	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Calsequestrin_1st	e1a8yA1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Calsequestrin_1st	ECOD (1.6)
A	Calsequestrin_2nd	e1a8yA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Calsequestrin_2nd	ECOD (1.6)
A	Calsequestrin_3rd	e1a8yA3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Calsequestrin_3rd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01216	Calsequestrin (Calsequestrin)	Calsequestrin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CALSEQUESTRIN	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding calcium ion binding potassium ion binding alkali metal ion binding identical protein binding protein binding protein homodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of store-operated calcium entry regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport cellular component organization cellular component biogenesis protein polymerization cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of store-operated calcium entry regulation of calcium ion transport regulation of localization regulation of biological process transport regulation of transport regulation of monoatomic ion transport biological regulation establishment of localization calcium ion transport metal ion transport localization store-operated calcium entry monoatomic ion transport monoatomic cation transport regulation of metal ion transport positive regulation of cation transmembrane transport positive regulation of calcium ion transport regulation of cellular process intracellular calcium ion homeostasis negative regulation of biological process positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport monoatomic cation homeostasis intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis cellular localization inorganic ion homeostasis homeostatic process monoatomic ion transmembrane transport positive regulation of biological process calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport intracellular chemical homeostasis positive regulation of release of sequestered calcium ion into cytosol regulation of sequestering of calcium ion positive regulation of cellular process calcium ion transmembrane import into cytosol sequestering of calcium ion cellular homeostasis positive regulation of transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport regulation of calcium ion transmembrane transporter activity regulation of store-operated calcium channel activity positive regulation of store-operated calcium channel activity positive regulation of cation channel activity regulation of cation channel activity regulation of molecular function regulation of transmembrane transporter activity regulation of transporter activity positive regulation of molecular function positive regulation of calcium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity positive regulation of transporter activity positive regulation of ion transmembrane transporter activity cellular response to stimulus multicellular organismal process system process response to stimulus regulation of system process sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum intracellular signal transduction cell communication multicellular organismal movement regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion intracellular signaling cassette signal transduction regulation of skeletal muscle contraction by calcium ion signaling release of sequestered calcium ion into cytosol by endoplasmic reticulum skeletal muscle contraction muscle contraction regulation of striated muscle contraction regulation of muscle contraction calcium-mediated signaling signaling striated muscle contraction musculoskeletal movement regulation of skeletal muscle contraction regulation of multicellular organismal process nervous system process neuromuscular process muscle system process regulation of muscle system process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cellular developmental process cellular component assembly involved in morphogenesis non-membrane-bounded organelle assembly cell development muscle cell differentiation muscle structure development striated muscle cell development cellular anatomical entity morphogenesis muscle cell development cell differentiation sarcomere organization anatomical structure development actin filament-based process developmental process actomyosin structure organization actin cytoskeleton organization organelle assembly anatomical structure morphogenesis myofibril assembly organelle organization anatomical structure formation involved in morphogenesis striated muscle cell differentiation supramolecular fiber organization cytoskeleton organization	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment intracellular organelle bounding membrane of organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane cytoplasm organelle membrane endoplasmic reticulum membrane membrane-enclosed lumen sarcoplasmic reticulum lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen mitochondrion mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR041858	Calsequestrin, middle TRX-fold domain	Domain
A	IPR001393	Calsequestrin	Family
A	IPR041860	Calsequestrin, C-terminal TRX-fold domain	Domain
A	IPR018233	Calsequestrin, conserved site	Conserved Site
A	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
A	IPR041859	Calsequestrin, N-terminal TRX-fold domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.