Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic acid is particularly important during phases of rapid cell division, such as infancy, pregnancy, and erythropoiesis, and plays a protective factor in the development of cancer. As humans are unable to synthesize folic acid endogenously, diet and supplementation is necessary to prevent deficiencies. For example, folic acid is present in green vegetables, beans, avocado, and some fruits.[L5744] In order to function within the body, folic acid must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF). This important pathway, which is required for de novo synthesis of nucleic acids and amino acids, is disrupted by anti-metabolite therapies such as [DB00563] as they function as DHFR inhibitors to prevent DNA synthesis in rapidly dividing cells, and therefore prevent the formation of DHF and THF. When used in high doses such as for cancer therapy, or in low doses such as for Rheumatoid Arthritis or psoriasis, [DB00563] impedes the body's ability to create folic acid. This results in a deficiency of coenzymes and a resultant buildup of toxic substances that are responsible for numerous adverse side effects. As a result, supplementation with 1-5mg of folic acid is recommended to prevent deficiency and a number of side effects associated with MTX therapy including mouth ulcers and gastrointestinal irritation. [DB00650] (also known as folinic acid) supplementation is typically used for high-dose MTX regimens for the treatment of cancer. Levoleucovorin and leucovorin are analogs of tetrahydrofolate (THF) and are able to bypass DHFR reduction to act as a cellular replacement for the co-factor THF. There are also several antiepileptic drugs (AEDs) that are associated with reduced serum and red blood cell folate, including [DB00564] (CBZ), [DB00252] (PHT), or barbiturates.[A37004] Folic acid is therefore often provided as supplementation to individuals using these medications, particularly to women of child-bearing age. Inadequate folate levels can result in a number of health concerns including cardiovascular disease, megaloblastic anemias, cognitive deficiencies, and neural tube defects (NTDs). Folic acid is typically supplemented during pregnancy to prevent the development of NTDs and in individuals with alcoholism to prevent the development of neurological disorders, for example.
Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA
TM-Vite RX
Acide Folique 5 Tab
Multi II IV Vi Tab
Complete One-A-day - Tab
Renal Caps Dialysis/Stress Vitamin Supplement
DuetDHA Balanced
Vp-pnv-dha
NataFort
TL-Folate
Fibrik
Calcium PNV
Super Multi
vitaMedMD Rx Plus
Se-Tan PLUS
B-complex Tab
Harvest Of Values All B Complex Tab
Vitafol OB Caplet
Vyo Cylate - Pwr
Viva Kids - Tab
Iron 25mg With Vit B-cmplx, Vit C, Cu & Mo
Balanced B-50 B-complex Vitamins, Timed Rele
Folivane-Plus with Ascorbic Acid Precursors
Ferrex 28
Folika-T
Tandem OB
Vena-Bal DHA
Multi Vitamins & Minerals
Ferotrin
Neomultivite
Prenatal Vitamin and Mineral Supplement -tab
Prometa
Hypo Vites Tab
Rulavite DHA
Formula Cn
Foliflex
AxiFol
Fem - Control
Feminex 300 Tab
CitraNatal 90 DHA
Fib-C Melts
Folic Acid 0.4mg Dietary Supplement
Multiple Vitamins & Minerals Tablets
Swiss One Multivitamin and Mineral Caplet
Shen Min Vitamin and Mineral Supplement
Virt-Bal DHA Plus
Kanga-V Multivitamins & Minerals
Multra Plex
L.I.P. Complex
One A Day Multiple Vit W Minerals
Multivitamin with fluoride
Ferrex 150 Forte
B 50 Capsules
Dayavite
Prenatal Plus Multivitamin Plus DHA MiniCaps
Gestamine Comprimes
hormaSAN forte
Leritone Antistress
Vasculine
Hematogen FA
Folic Acid (1mg Tablet)
Bio-b12
Lipo-B-C Tab
PNV Tabs 29-1
NuFera
Efferlife Multivitamins and Minerals
Corvita
Children's Chewable Multiple Vitamins With Extra Vitamin C (chewable Tablets)
Docosavit
Folic Acid
Stress B With 1000 Mg Vitamin C
Adult Formula 50+
Phytopure
FeRiva 21 7
Vp-heme Ob
Folcyteine
DuetDHA Complete
Multicaps
PR Natal 430 ec
Duet DHA 400 ec
TL-Select
Multivitamin & Multimineral
Multivitamin with Fluoride
NataChew
Concept DHA
Childrens Chewab Vitamin W Chel Minerals
Irospan 24/6
Stress Formula
Trinatal Rx 1
Nephron FA
Vitafol Plus
BiferaRx
CompleteNate Chewable
Vinate AZ
P.N. Vitamin-mineral Drink
B Compound 50mg Tab
Poly Vi Flor Chewable Tab
One Tablet Daily Mens Formula
Osteo-force
Multivitamines Pour Enfants (chewable Tablets)
Novo-folacid 5mg
MultiVitamin with Fluoride Chewable
Bev 29 Tab
Corvita 150
Pregnancy Multivitamin
Ultra Hr
Children's Chewable Multiple Vit.plus Iron
Vitaflex Dietary Suplement
Vitafol Caplet
Mycelized Childrens Multi-vitamin Liq
Balanced B-50 B-complex Vitamins Tab
Vita-vim - Tab
Multi-11
Magnum-75 Vitamin and Mineral Supplement
PNV Tabs 20-1
Vitachrom Gc
PreGenna
Tozal
Strovite One Caplets
Children's Chewable Tab
Nutra-Z
Prenaissance
Formula Gly
Nexa Select
Classic Swiss One 10 Multivitamin and Mineral Tab
Myferon 150 Forte
Stress Formula Multi-B Comp + 500mg Vit C Cap
Vitamin B Complex 50
V & M Vitamin and Mineral Supplement
MYNEPHROCAPS DIALYSIS/STRESS Vitamin Supplement
Ortho DF
Total Living Concepts Formula One - Tab
PreNexa
N.E.U. Complex
Dialyvite 5000
One A Day Tab
Vital Be-100
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Folica-V
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Multitabs
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Cavan Folate OB
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Am Caps
Fizz Multivitamins for Kids W C Loz
Bal-Care DHA Essential
K.L. Vitamin-mineral
Folic Acid Injection, USP
Vitrexyl plus Iron
C-B Complex
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B6, B12 & Folic Acid
Tar-end
One Daily VITES
Balanced B100
FolaGent DHA
Zolate
Focalgin DSS
Pregvit Folic 4
Vita-Pac
Active FE
Balanced B-complex Vit + Vit C&e Tab
Dialyvite with Zinc
Diaplex
Natalvirt FLT
Renate DHA
Vita-worth B-complex Tablets
PNV-Omega
Xyzbac
Virt-Nate
Paire OB Plus DHA
CitraNatal Essence
One-A-day Advance Men's
Twin G.F. Powder
Abavite
Natal PNV
TL-Select DHA
Homosismin
FUSION Sprinkles
Supplement De Vitamines Et Mineraux
VirtPrex
Cavan Heme OB
Prenatal Vitamins Plus Low Iron
Formula O-care Vitamin and Mineral Supplement
PreTAB
Twin Opti Pwr
Dr. AVi MULTIVITAMIN with Zinc, Real Ginger, Lemon and Lemongrass
Escavite
Feonyx
Complex-75
Omnivex
Zingiber
VP-Vite Rx
Hi Potency B Complex W Chelated Minerals
Nioxin Recharging Complex
NESTABS Prenatal Multi-vitamin/Mineral Supplement
Stress B Capsules With Vitamin C
Chewable Multivitamins Plus Iron
Orti B
Stress Complex 600 Avec Vit E Cuivre Zinc
Tricare Prenatal
Bal-Care DHA
Fusion Plus
Bacmin
Childrens Chewable Multiple Vitamins W.iron
Cool B
Dothelle DHA
Sandoz Folic Acid
Vigo Multivitamins Drops/lozenge
Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid
Prenatal
For Kids Only Chewable Multivitamins
Vit-HA Multi Vitamin and Zinc Supplement
Ferralet 90
Vitranol
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Nutra Boost
OB Complete Petite
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Foltamin
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Mvc 9+4 Inj
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Complete One A Day Tab
Folic Acid Tab 1mg
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Children's Chewable Multiple Vitamins With Iron Tablets (chewable Tablets)
Novel Vita
Prenate DHA
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PR Natal 400
Stresstabs + Zinc-copper
Vitafol
Tricare Prenatal DHA One Rx Multivitamin
Virt-Vite
Escavite D
Mega Plex IV - Pck
Nicazyme
Active OB
Pregvit Folic 5
CyFolex
Re Ob 90 DHA
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Mega Vitaminerals
Sodium polysulthionate and folic acid
Children's Chewable Vit and Min Tab
KeyFolic
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Formula F L W
Iron Folate Plus
Grand Master Formula Tab
Integra Plus
WesTab Plus
Iron Polysaccharides Folic Acid DHA
Sopalamine/3b Plus C
Iron Vitamins B6,b12,c,folic Acid Tab
B-Serene Rx
natelle COMPLETE
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Trigels-F Forte
Xyzmune
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Bentivite
Remedient
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Multi-vitamins With Minerals
Children's Chewable Multi-vitamin
Foltx
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PNV Ferrous Fumarate Docusate Folic Acid
Virt-Vite Plus
Vimeral Tab
Vita-B
RE Nata
Animi-3
VemaVite-PRx 2 with Fish-Based DHA
Vitabanks Vitamin Tab
Zavitrol
Iron Folate-F
Prenatvite
Infuvite Adult Multiple Vitamins
Se-Natal
Multiple Vitamins and Minerals
Concept OB
TL-Fol 500
Dotremin
Triveen-Duo DHA
A/o-26 - Caplet
BP Vit 3
Protect Cardio AF
Amerix Multivitamin
Prenavite Tablets
OB Complete DHA
Multivitamin & Minerals (iron Free)
Indication
Folic acid is indicated for the treatment of folic acid deficiency, megaloblastic anemia, and in anemias of nutritional origins, pregnancy, infancy, or childhood.
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
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