Annotations: 6CV9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08344,PF12796	e6cv9A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344,PF12796	ECOD (1.6)
B	PF08344,PF12796	e6cv9B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344,PF12796	ECOD (1.6)
C	PF08344,PF12796	e6cv9C1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344,PF12796	ECOD (1.6)
D	PF08344,PF12796	e6cv9D1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF08344,PF12796	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08344	Transient receptor ion channel II (TRP_2)	Transient receptor ion channel II	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Short transient receptor potential channel 6	clathrin binding protein binding binding monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity calcium channel activity store-operated calcium channel activity calcium ion transmembrane transporter activity clathrin binding protein binding binding monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity calcium channel activity store-operated calcium channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity cytoskeletal protein binding actinin binding identical protein binding protein homodimerization activity protein dimerization activity actin binding ion binding alcohol binding inositol 1,4,5 trisphosphate binding anion binding small molecule binding ATPase binding enzyme binding	positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-threonine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of cytosolic calcium ion concentration biological regulation regulation of biological quality regulation of cellular process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-threonine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process regulation of biological process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorus metabolic process metabolic process cellular process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process peptidyl-threonine phosphorylation sexual reproduction reproductive process fertilization single fertilization inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis multicellular organismal process cell projection organization negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation regulation of dendrite morphogenesis anatomical structure development system development developmental process negative regulation of cellular component organization regulation of cell projection organization nervous system development generation of neurons regulation of dendrite development negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization regulation of developmental process cellular developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis regulation of nervous system development cellular component organization negative regulation of neurogenesis neurogenesis dendrite development negative regulation of cellular process negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation cellular component organization or biogenesis negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of multicellular organismal development plasma membrane bounded cell projection organization negative regulation of dendrite morphogenesis negative regulation of developmental process dendrite morphogenesis cell morphogenesis involved in neuron differentiation negative regulation of cell development anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport calcium ion transmembrane transport cellular response to stimulus response to stimulus cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound cellular response to hydrogen peroxide response to reactive oxygen species response to inorganic substance response to hydrogen peroxide response to oxidative stress cellular response to reactive oxygen species cellular response to chemical stimulus cellular response to stress response to stress response to chemical positive regulation of neuron differentiation positive regulation of developmental process positive regulation of cell differentiation regulation of neuron differentiation regulation of localization regulation of calcium ion transport positive regulation of calcium ion transport regulation of transport regulation of monoatomic ion transport positive regulation of transport positive regulation of monoatomic ion transport regulation of metal ion transport	membrane cellular anatomical entity cell-cell junction anchoring junction cell junction filtration diaphragm slit diaphragm cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex transmembrane transporter complex membrane protein complex membrane cellular anatomical entity cell-cell junction anchoring junction cell junction filtration diaphragm slit diaphragm cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR002153	Transient receptor potential channel, canonical	Family
A, B, C, D	IPR013555	Transient receptor ion channel domain	Domain
A, B, C, D	IPR002110	Ankyrin repeat	Repeat
A, B, C, D	IPR005821	Ion transport domain	Domain
A, B, C, D	IPR005462	Transient receptor potential channel, canonical 6	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.