8RUU

Fabs derived from bimekizumab in complex with IL-17F

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.81 Å
  • R-Value Free: 0.241 
  • R-Value Work: 0.204 
  • R-Value Observed: 0.206 

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Ligand Structure Quality Assessment 


This is version 1.1 of the entry. See complete history. 


Literature

Crystal Structure of Bimekizumab Fab Fragment in Complex with IL-17F Provides Molecular Basis for Dual IL-17A and IL-17F Inhibition.

Adams, R., Bunick, C.G., Lawson, A.D.G., Gomez, B., Shaw, S.

(2024) J Invest Dermatol 


Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Immunoblobulin heavy chainA [auth B],
D [auth H]		228Homo sapiensMutation(s): 0 
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Immunoblobulin light chainB [auth C],
E [auth L]		214Homo sapiensMutation(s): 0 
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
Interleukin-17FC [auth X],
F [auth Y]		133Homo sapiensMutation(s): 0 
Gene Names: IL17F
UniProt & NIH Common Fund Data Resources
Find proteins for Q96PD4 (Homo sapiens)
Explore Q96PD4 
Go to UniProtKB:  Q96PD4
PHAROS:  Q96PD4
GTEx:  ENSG00000112116 
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UniProt GroupQ96PD4
Sequence Annotations
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  • Reference Sequence
Oligosaccharides

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Entity ID: 4
MoleculeChains Length2D Diagram Glycosylation3D Interactions
alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranoseG [auth A]5N-Glycosylation
Glycosylation Resources
GlyTouCan:  G26551VB
GlyCosmos:  G26551VB
GlyGen:  G26551VB
Small Molecules
Ligands 1 Unique
IDChains Name / Formula / InChI Key2D Diagram3D Interactions
NAG
Query on NAG
Download Ideal Coordinates CCD File 
H [auth Y]2-acetamido-2-deoxy-beta-D-glucopyranose
C8 H15 N O6
OVRNDRQMDRJTHS-FMDGEEDCSA-N
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.81 Å
  • R-Value Free: 0.241 
  • R-Value Work: 0.204 
  • R-Value Observed: 0.206 
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 99.15α = 90
b = 141.75β = 90
c = 145.56γ = 90
Software Package:
Software NamePurpose
PHENIXrefinement
PHASERphasing
xia2data scaling
XDSdata reduction

Structure Validation

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Ligand Structure Quality Assessment 


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Entry History & Funding Information

Deposition Data

Funding OrganizationLocationGrant Number
Not funded--

Revision History  (Full details and data files)

  • Version 1.0: 2024-04-24
    Type: Initial release
  • Version 1.1: 2024-05-01
    Changes: Database references