1TTN

Solution structure of the ubiquitin-like domain of human DC-UBP from dendritic cells


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 150 
  • Conformers Submitted: 15 
  • Selection Criteria: structures with the lowest energy 

wwPDB Validation   3D Report Full Report


This is version 1.4 of the entry. See complete history


Literature

Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells

Gao, Y.G.Song, A.X.Shi, Y.H.Chang, Y.G.Liu, S.X.Yu, Y.Z.Cao, X.T.Lin, D.H.Hu, H.Y.

(2005) Protein Sci 14: 2044-2050

  • DOI: https://doi.org/10.1110/ps.051455505
  • Primary Citation of Related Structures:  
    1TTN

  • PubMed Abstract: 

    The previously identified dendritic cell-derived ubiquitin-like protein (DC-UbP) was implicated in cellular differentiation and apoptosis. Sequence alignment suggested that it contains a ubiquitin-like (UbL) domain in the C terminus. Here, we present the solution NMR structure and backbone dynamics of the UbL domain of DC-UbP. The overall structure of the domain is very similar to that of Ub despite low similarity (<30%) in amino-acid sequence. One distinct feature of the domain structure is its highly positively charged surface that is different from the corresponding surfaces of the well-known UbL modifiers, Ub, NEDD8, and SUMO-1. The key amino-acid residues responsible for guiding polyubiquitinated proteins to proteasome degradation in Ub are not conserved in the UbL domain. This implies that the UbL domain of DC-UbP may have its own specific interaction partners with other yet unknown cellular functions related to the Ub pathway.


  • Organizational Affiliation

    Key Laboratory of Proteomics, Institute of Biochemsitry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, People's Republic of China.


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
dendritic cell-derived ubiquitin-like protein106Homo sapiensMutation(s): 0 
UniProt & NIH Common Fund Data Resources
Find proteins for Q8WUN7 (Homo sapiens)
Explore Q8WUN7 
Go to UniProtKB:  Q8WUN7
PHAROS:  Q8WUN7
GTEx:  ENSG00000168246 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ8WUN7
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 150 
  • Conformers Submitted: 15 
  • Selection Criteria: structures with the lowest energy 

Structure Validation

View Full Validation Report



Entry History 

Deposition Data

  • Released Date: 2005-07-05 
  • Deposition Author(s): Hu, H.Y.

Revision History  (Full details and data files)

  • Version 1.0: 2005-07-05
    Type: Initial release
  • Version 1.1: 2008-04-30
    Changes: Version format compliance
  • Version 1.2: 2011-07-13
    Changes: Version format compliance
  • Version 1.3: 2022-03-02
    Changes: Data collection, Database references, Derived calculations
  • Version 1.4: 2024-05-29
    Changes: Data collection