1TF3

TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES


Experimental Data Snapshot

  • Method: SOLUTION NMR
  • Conformers Calculated: 64 
  • Conformers Submitted: 22 
  • Selection Criteria: RESTRAINT ENERGIES < 11 KCAL, NO DISTANCE VIOLATIONS > 0.3 A 

wwPDB Validation   3D Report Full Report


This is version 1.4 of the entry. See complete history


Literature

Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA.

Foster, M.P.Wuttke, D.S.Radhakrishnan, I.Case, D.A.Gottesfeld, J.M.Wright, P.E.

(1997) Nat Struct Biol 4: 605-608

  • DOI: https://doi.org/10.1038/nsb0897-605
  • Primary Citation of Related Structures:  
    1TF3

  • PubMed Abstract: 

    The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.


Macromolecules

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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
TRANSCRIPTION FACTOR IIIAC [auth A]92Xenopus laevisMutation(s): 2 
UniProt
Find proteins for P03001 (Xenopus laevis)
Explore P03001 
Go to UniProtKB:  P03001
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupP03001
Sequence Annotations
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  • Reference Sequence

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Entity ID: 1
MoleculeChains LengthOrganismImage
5S RNA GENEA [auth E]15N/A
Sequence Annotations
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  • Reference Sequence

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Entity ID: 2
MoleculeChains LengthOrganismImage
5S RNA GENEB [auth F]15N/A
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: SOLUTION NMR
  • Conformers Calculated: 64 
  • Conformers Submitted: 22 
  • Selection Criteria: RESTRAINT ENERGIES < 11 KCAL, NO DISTANCE VIOLATIONS > 0.3 A 

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 1997-09-17
    Type: Initial release
  • Version 1.1: 2008-03-24
    Changes: Version format compliance
  • Version 1.2: 2011-07-13
    Changes: Version format compliance
  • Version 1.3: 2021-11-03
    Changes: Data collection, Database references, Derived calculations, Other
  • Version 1.4: 2024-05-22
    Changes: Data collection