Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase.
Georgiadis, M.M., Jessen, S.M., Ogata, C.M., Telesnitsky, A., Goff, S.P., Hendrickson, W.A.(1995) Structure 3: 879-892
- PubMed: 8535782 
- DOI: https://doi.org/10.1016/S0969-2126(01)00223-4
- Primary Citation of Related Structures:  
1MML - PubMed Abstract: 
Reverse transcriptase (RT) converts the single-stranded RNA genome of a retrovirus into a double-stranded DNA copy for integration into the host genome. This process requires ribonuclease H as well as RNA- and DNA-directed DNA polymerase activities. Although the overall organization of HIV-1 RT is known from previously reported crystal structures, no structure of a complex including a metal ion, which is essential for its catalytic activity, has been reported.
Organizational Affiliation: 
Waksman Institute, Rutgers University, Piscataway, NJ 08855, USA.